Our review on #acantholytic #skin #blistering disorders is out @thejidjournal.bsky.social. #Darier, #HaileyHailey, & #Grover dz weaken #desmosomes that hold the #epidermis together but lack any FDA-approved Tx. We summarize recent pubs pointing to new Tx strategies: www.jidonline.org/article/S002...

Read Harman et al's Review Article:
Pumping the Breaks on Acantholytic #skindisorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey–Hailey, and Grover Disease
doi.org/10.1016/j.ji...
#DermatologyJournal #dermatology #dermsky #dermatologists #dermresearch

Acantholytic cells in pemphigus vulgaris, H/T: Dr. Vasudev Prabhu

Correction (First author name):
Read Harmon et al's Review Article: Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey–Hailey, and Grover Disease doi.org/10.1016/j.ji...
#dermatology #dermsky #dermresearch

#TooCloseToDiagnose? 🧐
Acantholysis + Atypia
A. Acantholytic Actinic Keratosis
B. Darier disease
C. Grover disease
D. Warty dyskeratoma
#Pathology #Dermatology #Dermatopathology #DermPath

Grover's Disease... aka transient acantholytic dermatosis

❌ Grover disease
-Focal acantholytic dyskeratosis
-Small discrete foci
-Mixed histologic patterns (Darier/HH/Pemphigus-like)

Acantholytic AK: Atypia + solar elastosis + follicular sparing.
dpa-dapa.com/public/displ...
Warty Dyskeratoma: Solitary cup-shaped
dpa-dapa.com/public/displ...
Grovers: Focal mixed acantholysis
dpa-dapa.com/public/displ...
Dariers: Widespread corps ronds, grains, villi
dpa-dapa.com/public/displ...

✅ Acantholytic Actinic Keratosis
-Suprabasilar acantholysis mimicking pemphigus/HH
-Cytologic atypia of basal layer
-Sparing of adnexal structures (hair follicles)
-Background of solar elastosis

❌ Grover disease
-Focal acantholytic dyskeratosis
-Small discrete foci
-"Transient" clinical course

2nd chance! Lower power.
What is the diagnosis?
A. Acantholytic Actinic Keratosis
B. Darier disease
C. Grover disease
D. Warty dyskeratoma

✅ Squamous Cell Carcinoma (acantholytic type)
Pseudoglandular spaces due to loss of cohesion between squamous cells
Key: NO true glandular differentiation (i.e., no mucin)
Diffusely p40 positive, Ber-EP4/EpCAM (adenocarcinomas) negative
🔬 rosai.secondslide.com/view/sem1142...
#ENTPath #PathSky

Grover disease, an underdiagnosed acantholytic condition, should be considered for itchy, keratotic papules with crusting on the chest and back. "I think we are underdiagnosing" this condition, said dermatology chair Adam Friedman, MD, at ElderDerm 2025. ms.spr.ly/63322seVnn

I love dermatology talks because they usually include pathology images! Derm specialist Dr Jacquelyn Campbell showing some nice acantholytic cells in her case discussion of pemphigus foliaceus. #AVMA2018