Excited to share work out in @jacs.acspublications.org led by Yuxuan and @genlichem.bsky.social on activity-based sensing of acetaldehyde using an inverse electron-demand Diels-Alder reaction, enabling selective detection of two-carbon metabolism! pubs.acs.org/doi/10.1021/...
An Inverse Electron-Demand Diels–Alder Approach to Selective Activity-Based Sensing of Acetaldehyde in Living Cells
Acetaldehyde (AA) is a reactive aldehyde primarily produced in cells as a metabolic intermediate during ethanol oxidation. Excess AA, often resulting from impaired AA detoxification, leads to aberrant...
pubs.acs.org
October 16, 2025 at 7:22 PM
Excited to share work out in @jacs.acspublications.org led by Yuxuan and @genlichem.bsky.social on activity-based sensing of acetaldehyde using an inverse electron-demand Diels-Alder reaction, enabling selective detection of two-carbon metabolism! pubs.acs.org/doi/10.1021/...
life is a constant battle to defend the honour of the beautiful maiden ethanol against the traitorous ploys of the blackgaurd acetaldehyde
July 8, 2026 at 2:53 PM
life is a constant battle to defend the honour of the beautiful maiden ethanol against the traitorous ploys of the blackgaurd acetaldehyde
Here's my problem with this report:
The alleged primary carcinogen, acetaldehyde?
It's -EVERYWHERE-.
Bread, fruit, vegetables, coffee, dairy products, honey, soda, iced tea, even MUSTARD.
pmc.ncbi.nlm.nih.gov/articles/PMC...
The alleged primary carcinogen, acetaldehyde?
It's -EVERYWHERE-.
Bread, fruit, vegetables, coffee, dairy products, honey, soda, iced tea, even MUSTARD.
pmc.ncbi.nlm.nih.gov/articles/PMC...
September 5, 2025 at 4:28 PM
Here's my problem with this report:
The alleged primary carcinogen, acetaldehyde?
It's -EVERYWHERE-.
Bread, fruit, vegetables, coffee, dairy products, honey, soda, iced tea, even MUSTARD.
pmc.ncbi.nlm.nih.gov/articles/PMC...
The alleged primary carcinogen, acetaldehyde?
It's -EVERYWHERE-.
Bread, fruit, vegetables, coffee, dairy products, honey, soda, iced tea, even MUSTARD.
pmc.ncbi.nlm.nih.gov/articles/PMC...
For my first post of 2025, here's the now-traditional graphic on the biochemistry behind hangovers for #NationalHangoverDay. Happy New Year to you all!
www.compoundchem.com/2016/01/01/h...
#ChemSky 🧪
www.compoundchem.com/2016/01/01/h...
#ChemSky 🧪
January 1, 2025 at 8:41 AM
For my first post of 2025, here's the now-traditional graphic on the biochemistry behind hangovers for #NationalHangoverDay. Happy New Year to you all!
www.compoundchem.com/2016/01/01/h...
#ChemSky 🧪
www.compoundchem.com/2016/01/01/h...
#ChemSky 🧪
Brilliant!😀👍 Sounds like you've discovered a cornerstone of Joshual Leisk's (BornFree) disease model.
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
August 2, 2025 at 10:36 PM
Brilliant!😀👍 Sounds like you've discovered a cornerstone of Joshual Leisk's (BornFree) disease model.
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
Zinc depleted by chronic pathogen acetaldehyde production & DMT-1 transporter blockade.
Zinc a cofactor for methylation, all histamine/catecholamine, etc, degradation, activating B-vits, etc.
1/2
I feel acetaldehyde...
October 20, 2025 at 1:00 AM
I feel acetaldehyde...
Methanol gets converted into formaldehyde, by the alcohol dehydrogenase enzyme (which, in the normal course of events, converts ethanol into acetaldehyde).
Formaldehyde is much more poisonous than acetaldehyde is - also, the enzyme will convert methanol BEFORE it does ethanol, given the choice.
Formaldehyde is much more poisonous than acetaldehyde is - also, the enzyme will convert methanol BEFORE it does ethanol, given the choice.
November 24, 2024 at 11:53 PM
Methanol gets converted into formaldehyde, by the alcohol dehydrogenase enzyme (which, in the normal course of events, converts ethanol into acetaldehyde).
Formaldehyde is much more poisonous than acetaldehyde is - also, the enzyme will convert methanol BEFORE it does ethanol, given the choice.
Formaldehyde is much more poisonous than acetaldehyde is - also, the enzyme will convert methanol BEFORE it does ethanol, given the choice.
Why does red wine trigger headaches for some people?
Chemists say the answer may lie in quercetin, a natural compound in grape skins that can interfere with alcohol metabolism and spike acetaldehyde levels.
theconversation.com/why-does-red...
#wine #headaches #health 🧪
Chemists say the answer may lie in quercetin, a natural compound in grape skins that can interfere with alcohol metabolism and spike acetaldehyde levels.
theconversation.com/why-does-red...
#wine #headaches #health 🧪
December 15, 2025 at 11:36 PM
Why does red wine trigger headaches for some people?
Chemists say the answer may lie in quercetin, a natural compound in grape skins that can interfere with alcohol metabolism and spike acetaldehyde levels.
theconversation.com/why-does-red...
#wine #headaches #health 🧪
Chemists say the answer may lie in quercetin, a natural compound in grape skins that can interfere with alcohol metabolism and spike acetaldehyde levels.
theconversation.com/why-does-red...
#wine #headaches #health 🧪
Acetate is not the dangerous metabolite - it's basically vinegar.
The dangerous metabolite of alcohol is the intermediate acetaldehyde - (ehtanol -> acetaldehyde -> acetate)
The dangerous metabolite of alcohol is the intermediate acetaldehyde - (ehtanol -> acetaldehyde -> acetate)
July 20, 2025 at 5:40 PM
Acetate is not the dangerous metabolite - it's basically vinegar.
The dangerous metabolite of alcohol is the intermediate acetaldehyde - (ehtanol -> acetaldehyde -> acetate)
The dangerous metabolite of alcohol is the intermediate acetaldehyde - (ehtanol -> acetaldehyde -> acetate)
Battling a post-NYE hangover? Here’s what we know about the biochemistry of alcohol’s effects on the body: www.compoundchem.com/2016/01/01/h...
#ChemSky 🧪
#ChemSky 🧪
January 1, 2026 at 1:30 PM
Battling a post-NYE hangover? Here’s what we know about the biochemistry of alcohol’s effects on the body: www.compoundchem.com/2016/01/01/h...
#ChemSky 🧪
#ChemSky 🧪
Hydrogenation Of Acetaldehyde On Interstellar Ice Analogs Reveals Limited Destruction
astrobiology.com/2024/12/hydr... #astrobiology #astrochemistry #interstellar #astronomy
astrobiology.com/2024/12/hydr... #astrobiology #astrochemistry #interstellar #astronomy
Hydrogenation Of Acetaldehyde On Interstellar Ice Analogs Reveals Limited Destruction - Astrobiology
We sought to determine which are the main hydrogenation paths of acetaldehyde (CH3CHO)
astrobiology.com
December 24, 2024 at 6:11 PM
Hydrogenation Of Acetaldehyde On Interstellar Ice Analogs Reveals Limited Destruction
astrobiology.com/2024/12/hydr... #astrobiology #astrochemistry #interstellar #astronomy
astrobiology.com/2024/12/hydr... #astrobiology #astrochemistry #interstellar #astronomy
Your liver turns alcohol into acetaldehyde. ZBiotics introduces a bacteria to break that down further into acetate in your gut, intended to reduce hangovers the next day.
True RCTs on effectiveness lacking
True RCTs on effectiveness lacking
June 24, 2026 at 11:12 PM
Your liver turns alcohol into acetaldehyde. ZBiotics introduces a bacteria to break that down further into acetate in your gut, intended to reduce hangovers the next day.
True RCTs on effectiveness lacking
True RCTs on effectiveness lacking
A few 3D prints from this week's organic chemistry class: an NBO enolate alkylation transition state and a pi MO model for the enolate of acetaldehyde. We reviewed the SN2 reaction and noted the larger "on-C" orbital of the nucleophilic pi2 MO! #ChemSky #CompChemSky #3DP #3Dprint #3DModels #prusa 🧪
March 6, 2025 at 6:09 PM
acetaldehyde breakdown is inhibited by some of the chemicals in tea, so a coffee is better than a tea for a hangover. however acetaldehyde breakdown is hastened by taurine. which means that unironically the best hangover cure is actually to slam a monster energy drink
July 13, 2025 at 10:23 PM
acetaldehyde breakdown is inhibited by some of the chemicals in tea, so a coffee is better than a tea for a hangover. however acetaldehyde breakdown is hastened by taurine. which means that unironically the best hangover cure is actually to slam a monster energy drink
As part of #dryjanuary ,
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
January 11, 2025 at 11:46 PM
As part of #dryjanuary ,
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
it is important to know that the metabolite of alcohol, acetaldehyde, is a class one carcinogen. If you are alcohol intolerant, you will accumulate acetaldehyde, that over time can cause DNA damage that can lead to cancer. #alcohol #genetics #Aldh2
Pssstt chat, candida overgrowth (the white on the tongue) is ever so present oh so often in long covid because it makes acetaldehyde-salsolinol which is toxic to the like whole dopamine system.
There is an overlap in worst cases that is being ignored off this.
There is an overlap in worst cases that is being ignored off this.
The COVID brain fog explained.
The COVID-19 virus binds to the ACE2 receptor to enter cells. Dopamine producing neurons are rich in the ACE2 receptor.
The virus causes disruption in the dopamine network in the brain.
🧪 tech-paper.com/scientists-f...
The COVID-19 virus binds to the ACE2 receptor to enter cells. Dopamine producing neurons are rich in the ACE2 receptor.
The virus causes disruption in the dopamine network in the brain.
🧪 tech-paper.com/scientists-f...
Scientists finally have a biological explanation for why long COVID patients lose motivation and can't think clearly. They scanned their brains and found the dopamine system was physically damaged - T...
Millions of people with long COVID report the same cluster of symptoms: a crushing lack of motivation, an inability to think clearly, memory that slips, movements that feel slower than they should. Fo...
tech-paper.com
August 2, 2026 at 12:17 AM
Pssstt chat, candida overgrowth (the white on the tongue) is ever so present oh so often in long covid because it makes acetaldehyde-salsolinol which is toxic to the like whole dopamine system.
There is an overlap in worst cases that is being ignored off this.
There is an overlap in worst cases that is being ignored off this.
i can smell the acetaldehyde metabolizing out of his pores from here
January 7, 2026 at 1:45 AM
i can smell the acetaldehyde metabolizing out of his pores from here
Really coulda used this info in the 90's. I just ate Long John Silver's the next day in the hopes that the grease would soak up the booze.
July 14, 2025 at 4:02 PM
Really coulda used this info in the 90's. I just ate Long John Silver's the next day in the hopes that the grease would soak up the booze.
"The only byproduct was acetaldehyde, an easily removable industrial chemical with commercial value."
Acetaldehyde is a solvent in the rubber, tanning and paper industries, and is considered a probable human carcinogen.
So yeah. Sounds FANTASTIC. Really. 🤡
Acetaldehyde is a solvent in the rubber, tanning and paper industries, and is considered a probable human carcinogen.
So yeah. Sounds FANTASTIC. Really. 🤡
March 13, 2025 at 2:05 PM
"The only byproduct was acetaldehyde, an easily removable industrial chemical with commercial value."
Acetaldehyde is a solvent in the rubber, tanning and paper industries, and is considered a probable human carcinogen.
So yeah. Sounds FANTASTIC. Really. 🤡
Acetaldehyde is a solvent in the rubber, tanning and paper industries, and is considered a probable human carcinogen.
So yeah. Sounds FANTASTIC. Really. 🤡
Since we already established AMINOCYCLOPROPANOL is an inhibitor of aldehyde dehydrogenase, it stops the conversion of acetaldehyde to acetic acid, building up acetaldehyde in the body, making you feel super sick and nauseous.
December 3, 2024 at 2:17 PM
Since we already established AMINOCYCLOPROPANOL is an inhibitor of aldehyde dehydrogenase, it stops the conversion of acetaldehyde to acetic acid, building up acetaldehyde in the body, making you feel super sick and nauseous.
"Ethanol and acetaldehyde (ethanal), both categorized by IARC as group 1 carcinogens, are the primary carcinogens occurring in alcoholic beverages accounting for approximately
5.5% of all cancer cases worldwide"
That's a LOT of Cancer. www.mdpi.com/2072-6643/13...
5.5% of all cancer cases worldwide"
That's a LOT of Cancer. www.mdpi.com/2072-6643/13...
www.mdpi.com
January 4, 2025 at 6:04 AM
"Ethanol and acetaldehyde (ethanal), both categorized by IARC as group 1 carcinogens, are the primary carcinogens occurring in alcoholic beverages accounting for approximately
5.5% of all cancer cases worldwide"
That's a LOT of Cancer. www.mdpi.com/2072-6643/13...
5.5% of all cancer cases worldwide"
That's a LOT of Cancer. www.mdpi.com/2072-6643/13...
Acetaldehyde has a cidery aroma and a curious, flat texture. For examples of the flavors, look to intentionally oxidized wines like sherry and madeira: the taste that distinguishes these beverages from traditional wine is their the elevated level of acetaldehyde. 3/
December 23, 2024 at 2:51 AM
Acetaldehyde has a cidery aroma and a curious, flat texture. For examples of the flavors, look to intentionally oxidized wines like sherry and madeira: the taste that distinguishes these beverages from traditional wine is their the elevated level of acetaldehyde. 3/