Fascinating. A gut bacteria (Aeromonas variant) makes a toxin called aerolysin that kills gut macrophages and increases inflammation in Ulcerative Colitis.
Anti-aerolysin antibodies stopped the colitis in mice. Wow!
Could this be a new treatment for UC?
#medsky #GIsky 🧪
Anti-aerolysin antibodies stopped the colitis in mice. Wow!
Could this be a new treatment for UC?
#medsky #GIsky 🧪
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 9:29 PM
Our latest JACS paper: high-resolution cryoEM of #aerolysin in lipid environment shows pore properties and 4 key constriction rings for #nanopore sensing. Collaboration with #DalPeraro & #Cao labs.
@coldpopeye.bsky.social
@unibern.bsky.social
#EPFL #UNIGE #DubochetCenter #MIC
shorturl.at/qyzbb
@coldpopeye.bsky.social
@unibern.bsky.social
#EPFL #UNIGE #DubochetCenter #MIC
shorturl.at/qyzbb
Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment
Aerolysin is a β-pore-forming toxin produced by most Aeromonas bacteria, which has attracted large attention in the field of nanopore sensing due to its narrow and charged pore lumen. Structurally sim...
shorturl.at
February 4, 2025 at 8:28 AM
Our latest JACS paper: high-resolution cryoEM of #aerolysin in lipid environment shows pore properties and 4 key constriction rings for #nanopore sensing. Collaboration with #DalPeraro & #Cao labs.
@coldpopeye.bsky.social
@unibern.bsky.social
#EPFL #UNIGE #DubochetCenter #MIC
shorturl.at/qyzbb
@coldpopeye.bsky.social
@unibern.bsky.social
#EPFL #UNIGE #DubochetCenter #MIC
shorturl.at/qyzbb
The adults are also adorable little fuzzy guys, lacking the venomous spines.
The aerolysin venom cocktail also has insecticidal properties at very high doses, reducing the chance the caterpillar will be eaten or injected by other insects (wasps, etc).
(📷: Patrick Coin, Wikimedia)
The aerolysin venom cocktail also has insecticidal properties at very high doses, reducing the chance the caterpillar will be eaten or injected by other insects (wasps, etc).
(📷: Patrick Coin, Wikimedia)
July 9, 2024 at 1:32 PM
The adults are also adorable little fuzzy guys, lacking the venomous spines.
The aerolysin venom cocktail also has insecticidal properties at very high doses, reducing the chance the caterpillar will be eaten or injected by other insects (wasps, etc).
(📷: Patrick Coin, Wikimedia)
The aerolysin venom cocktail also has insecticidal properties at very high doses, reducing the chance the caterpillar will be eaten or injected by other insects (wasps, etc).
(📷: Patrick Coin, Wikimedia)
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
scim.ag
November 24, 2025 at 10:00 PM
A toxin-secreting gut bacterium may fuel ulcerative colitis by killing protective immune cells that maintain intestinal homeostasis, according to a new study in Science.
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
The findings suggest potential for new treatment strategies. https://scim.ag/4rjvjqA
"Administration of anti-aerolysin antibodies provided protection against colitis in mice that were exposed to the Aeromonas variant. "—Sarah H. Ross
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 20, 2025 at 8:07 PM
"Administration of anti-aerolysin antibodies provided protection against colitis in mice that were exposed to the Aeromonas variant. "—Sarah H. Ross
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@kevinzhong2006.bsky.social shows that Vibrio pectenicida strain FHCF-3 has the genetic potential to produce aerolysin-like toxins journals.asm.org/doi/10.1128/... that could be involved in SSWD that killed billions of seastars www.nature.com/articles/s41...
August 19, 2025 at 1:14 AM
@kevinzhong2006.bsky.social shows that Vibrio pectenicida strain FHCF-3 has the genetic potential to produce aerolysin-like toxins journals.asm.org/doi/10.1128/... that could be involved in SSWD that killed billions of seastars www.nature.com/articles/s41...
en.wikipedia.org/wiki/Aerolysin
This shit is NASTY - designed to punch holes right though our toughest cell membranes AND kills the protective macrophages!
www.science.org/doi/10.1126/...
We need a national initiative for nanotech.
This shit is NASTY - designed to punch holes right though our toughest cell membranes AND kills the protective macrophages!
www.science.org/doi/10.1126/...
We need a national initiative for nanotech.
Aerolysin - Wikipedia
en.wikipedia.org
November 21, 2025 at 3:06 AM
en.wikipedia.org/wiki/Aerolysin
This shit is NASTY - designed to punch holes right though our toughest cell membranes AND kills the protective macrophages!
www.science.org/doi/10.1126/...
We need a national initiative for nanotech.
This shit is NASTY - designed to punch holes right though our toughest cell membranes AND kills the protective macrophages!
www.science.org/doi/10.1126/...
We need a national initiative for nanotech.
Verena Rukes telling us about: Charge-based fingerprinting of unlabeled full-length proteins using an
aerolysin nanopore
aerolysin nanopore
January 20, 2025 at 11:44 AM
Verena Rukes telling us about: Charge-based fingerprinting of unlabeled full-length proteins using an
aerolysin nanopore
aerolysin nanopore
Really cool paper on a likely bacterial cause of ulcerative colitis.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
www.science.org
November 24, 2025 at 4:40 PM
Really cool paper on a likely bacterial cause of ulcerative colitis.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The latest paper from my lab! Aerolysin toxins in Saccharomyces yeasts (they "seemed" to be yeast-specific - so maybe(?) don't worry!) | mBio journals.asm.org/doi/10.1128/...
The Saccharomyces killer toxin K62 is a protein of the aerolysin family | mBio
Pore-forming toxins are potent biological weapons used across nature, from virulence
factors to immune defense proteins. This study identifies K62, a little-known antifungal
toxin produced by a wild y...
journals.asm.org
November 13, 2025 at 6:25 PM
The latest paper from my lab! Aerolysin toxins in Saccharomyces yeasts (they "seemed" to be yeast-specific - so maybe(?) don't worry!) | mBio journals.asm.org/doi/10.1128/...
New in Science:
Ulcerative colitis-derived Aeromonas strain produces aerolysin that is far more toxic to macrophages than epithelial cells
In mice, the same isolate colonizes, depletes macrophages, and triggers colitis—recapitulating the macrophage loss seen in UC patients
Toxin as drug target?
Ulcerative colitis-derived Aeromonas strain produces aerolysin that is far more toxic to macrophages than epithelial cells
In mice, the same isolate colonizes, depletes macrophages, and triggers colitis—recapitulating the macrophage loss seen in UC patients
Toxin as drug target?
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Ulcerative colitis (UC) is a severe inflammatory bowel disease affecting millions of people worldwide, but the factors driving the condition are poorly understood. In tissue samples from individuals w...
www.science.org
November 22, 2025 at 1:59 PM
New in Science:
Ulcerative colitis-derived Aeromonas strain produces aerolysin that is far more toxic to macrophages than epithelial cells
In mice, the same isolate colonizes, depletes macrophages, and triggers colitis—recapitulating the macrophage loss seen in UC patients
Toxin as drug target?
Ulcerative colitis-derived Aeromonas strain produces aerolysin that is far more toxic to macrophages than epithelial cells
In mice, the same isolate colonizes, depletes macrophages, and triggers colitis—recapitulating the macrophage loss seen in UC patients
Toxin as drug target?
Токсин аэролизин оказался способен избирательно убивать макрофагов кишечника и тем самым делать кишечник более уязвимым к язвенному колиту
https://nplus1.ru/news/2025/11/26/aerolysin-killed-macrophages
https://nplus1.ru/news/2025/11/26/aerolysin-killed-macrophages
November 26, 2025 at 1:44 PM
Токсин аэролизин оказался способен избирательно убивать макрофагов кишечника и тем самым делать кишечник более уязвимым к язвенному колиту
https://nplus1.ru/news/2025/11/26/aerolysin-killed-macrophages
https://nplus1.ru/news/2025/11/26/aerolysin-killed-macrophages
🚀 From Bench to Paper | Aerolysin-Producing Aeromonas & #UlcerativeColitis
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
December 1, 2025 at 8:01 PM
🚀 From Bench to Paper | Aerolysin-Producing Aeromonas & #UlcerativeColitis
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
A #Science study shows an #Aeromonas variant kills macrophages, promotes colitis, and is more common in UC patients. Anti-aerolysin antibodies reduce inflammation.
#Microbiome #Immunology #GutHealth
Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment pubmed.ncbi.nlm.nih.gov/39900531/ #cryoem
February 4, 2025 at 7:40 PM
Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment pubmed.ncbi.nlm.nih.gov/39900531/ #cryoem
Exploring new nanopore sensors from the aerolysin family https://www.biorxiv.org/content/10.1101/2024.04.07.588449v1
Exploring new nanopore sensors from the aerolysin family https://www.biorxiv.org/content/10.1101/2024.04.07.588449v1
Aerolysin-like proteins are a family of {beta}-pore-forming toxins which are widely present in all k
www.biorxiv.org
April 10, 2024 at 9:47 PM
Exploring new nanopore sensors from the aerolysin family https://www.biorxiv.org/content/10.1101/2024.04.07.588449v1
Leishmanial GP63 acts as a protease for the small pore forming toxin aerolysin www.biorxiv.org/content/10.64898/2026.07.29.741567v1
July 31, 2026 at 7:15 AM
Leishmanial GP63 acts as a protease for the small pore forming toxin aerolysin www.biorxiv.org/content/10.64898/2026.07.29.741567v1
Sub-Nanomolar Detection and Discrimination of Microcystin Congeners Using Aerolysin Nanopores https://www.biorxiv.org/content/10.1101/2025.07.15.664886v1
July 18, 2025 at 11:47 PM
Sub-Nanomolar Detection and Discrimination of Microcystin Congeners Using Aerolysin Nanopores https://www.biorxiv.org/content/10.1101/2025.07.15.664886v1
Leishmanial GP63 acts as a protease for the small pore forming toxin aerolysin pubmed.ncbi.nlm.nih.gov/42619877/
August 21, 2026 at 7:31 PM
Leishmanial GP63 acts as a protease for the small pore forming toxin aerolysin pubmed.ncbi.nlm.nih.gov/42619877/
Charge-based fingerprinting of unlabeled full-length proteins using an aerolysin nanopore https://www.biorxiv.org/content/10.1101/2025.01.13.632743v1
January 17, 2025 at 1:03 AM
Charge-based fingerprinting of unlabeled full-length proteins using an aerolysin nanopore https://www.biorxiv.org/content/10.1101/2025.01.13.632743v1
The Rowley/Ytreberg/Patel labs at UI have led a multidisciplinary study to characterize a new yeast toxin! Published in the ASM's flagship Journal - mBio. Eight undergraduate authors contributed to the study, a great team effort! journals.asm.org/doi/10.1128/... @uidaho.bsky.social
The Saccharomyces killer toxin K62 is a protein of the aerolysin family | mBio
Pore-forming toxins are potent biological weapons used across nature, from virulence
factors to immune defense proteins. This study identifies K62, a little-known antifungal
toxin produced by a wild y...
journals.asm.org
November 13, 2025 at 8:45 PM
The Rowley/Ytreberg/Patel labs at UI have led a multidisciplinary study to characterize a new yeast toxin! Published in the ASM's flagship Journal - mBio. Eight undergraduate authors contributed to the study, a great team effort! journals.asm.org/doi/10.1128/... @uidaho.bsky.social
🧪Researchers identified a toxin-producing Aeromonas bacterium in humans with ulcerative colitis, but not in those without the disease. The bacteria were found to promote colon inflammation in mice. Treatment with an anti-aerolysin antibody reduced mice’s disease severity: https://ow.ly/wXMl50YomJe
![A toxin-producing bacterium promotes susceptibility to ulcerative colitis. [Petri dish with streaks of toxin-producing bacteria growing on red agar medium.]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:zjk7ijv5msnlxjoow2dmpaju/bafkreigcd6dfrtyrqengv4gxehkaxhszdaqm4cpu5zxcp5awhvgsi2loyi)
March 6, 2026 at 3:20 PM
🧪Researchers identified a toxin-producing Aeromonas bacterium in humans with ulcerative colitis, but not in those without the disease. The bacteria were found to promote colon inflammation in mice. Treatment with an anti-aerolysin antibody reduced mice’s disease severity: https://ow.ly/wXMl50YomJe
New in JB: Kobayashi, Yamanaka et al. show that the serine protease of A. veronii cleaves pro-aerolysin into a hemolytically active toxin, to facilitate crossing the host epithelial barrier via targeting host EpCAM.
pubmed.ncbi.nlm.nih.gov/42429552/
@asm.org #JBacteriol @microsky.bsky.social
pubmed.ncbi.nlm.nih.gov/42429552/
@asm.org #JBacteriol @microsky.bsky.social
September 16, 2026 at 6:37 PM
New in JB: Kobayashi, Yamanaka et al. show that the serine protease of A. veronii cleaves pro-aerolysin into a hemolytically active toxin, to facilitate crossing the host epithelial barrier via targeting host EpCAM.
pubmed.ncbi.nlm.nih.gov/42429552/
@asm.org #JBacteriol @microsky.bsky.social
pubmed.ncbi.nlm.nih.gov/42429552/
@asm.org #JBacteriol @microsky.bsky.social
Draft genome sequence of Vibrio pectenicida strain FHCF-3, a causative agent of sea star wasting disease in the sunflower sea star (Pycnopodia helianthoides), reveals the genetic potential to produce aerolysin-like toxins | Microbiology Resource Announcements journals.asm.org/doi/10.1128/...
Draft genome sequence of Vibrio pectenicida strain FHCF-3, a causative agent of sea star wasting disease in the sunflower sea star (Pycnopodia helianthoides), reveals the genetic potential to produce ...
Sunflower sea stars (Pycnopodia helianthoides) along the Pacific coast have been devastated by sea star wasting disease (SSWD)
(1). Here, we report the draft genome of Vibrio pectenicida strain FHCF-3...
journals.asm.org
August 16, 2025 at 1:23 AM
Draft genome sequence of Vibrio pectenicida strain FHCF-3, a causative agent of sea star wasting disease in the sunflower sea star (Pycnopodia helianthoides), reveals the genetic potential to produce aerolysin-like toxins | Microbiology Resource Announcements journals.asm.org/doi/10.1128/...
Aerolysin enables modular, non-genetic functionalization of living cell surfaces https://www.biorxiv.org/content/10.64898/2026.08.28.746739v1
August 31, 2026 at 4:45 PM
Aerolysin enables modular, non-genetic functionalization of living cell surfaces https://www.biorxiv.org/content/10.64898/2026.08.28.746739v1
Aerolysin enables modular, non-genetic functionalization of living cell surfaces https://www.biorxiv.org/content/10.64898/2026.08.28.746739v1
August 31, 2026 at 4:45 PM
Aerolysin enables modular, non-genetic functionalization of living cell surfaces https://www.biorxiv.org/content/10.64898/2026.08.28.746739v1