A new treatment, an aldosterone synthase inhibitor, for uncontrolled or resistant hypertension, Phase 3 trial
@nejm.org
#ESC2025 today
nejm.org/doi/full/10....
@nejm.org
#ESC2025 today
nejm.org/doi/full/10....
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension | NEJM
Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pr...
nejm.org
August 30, 2025 at 3:39 PM
A new treatment, an aldosterone synthase inhibitor, for uncontrolled or resistant hypertension, Phase 3 trial
@nejm.org
#ESC2025 today
nejm.org/doi/full/10....
@nejm.org
#ESC2025 today
nejm.org/doi/full/10....
First post on BlueSky HAS to be Aldosterone. He’s really glad to be here.
November 11, 2024 at 3:47 PM
First post on BlueSky HAS to be Aldosterone. He’s really glad to be here.
The ASIs have arrived
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...
www.nejm.org
April 23, 2025 at 10:01 PM
The ASIs have arrived
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
www.nejm.org/doi/full/10....
Aldosterone synthase inhibitors - first one to finish the phase 3 line
#Lorundrostat #Hypertension
In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results: nej.md/40Js1kz
#ENDO2025
#ENDO2025
July 13, 2025 at 10:06 PM
In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results: nej.md/40Js1kz
#ENDO2025
#ENDO2025
Note that aldosterone escape refers to escape from the effects of aldosterone under some conditions
And aldosterone breakthrough is the term for continued aldosterone production despite renin-angiotensin blockade
And aldosterone breakthrough is the term for continued aldosterone production despite renin-angiotensin blockade
Aldosterone escape effect:
Classic RAAS blockers can’t fully shut down aldosterone production.
Braxdrostat in the BrightHTN showed SBP reduction, PRA suppresion and no cortisol suppresion #NephJC @nephmadness.bsky.social 2025
Classic RAAS blockers can’t fully shut down aldosterone production.
Braxdrostat in the BrightHTN showed SBP reduction, PRA suppresion and no cortisol suppresion #NephJC @nephmadness.bsky.social 2025
May 27, 2025 at 11:56 PM
Note that aldosterone escape refers to escape from the effects of aldosterone under some conditions
And aldosterone breakthrough is the term for continued aldosterone production despite renin-angiotensin blockade
And aldosterone breakthrough is the term for continued aldosterone production despite renin-angiotensin blockade
🧮 Aldosterone renin ratio (ARR): a Double-Edged Sword? 🤔
⚠️ Meds, salt intake, posture, hypokalemia, circadian rhythm, assay variability—all impact results! Too many variables!!! #NephJC
How do you adjust ARR interpretation in clinical practice?
⚠️ Meds, salt intake, posture, hypokalemia, circadian rhythm, assay variability—all impact results! Too many variables!!! #NephJC
How do you adjust ARR interpretation in clinical practice?
Diagnosing Aldosteronism — NephJC
aldosterone; hypertension
www.nephjc.com
February 26, 2025 at 2:13 AM
🧮 Aldosterone renin ratio (ARR): a Double-Edged Sword? 🤔
⚠️ Meds, salt intake, posture, hypokalemia, circadian rhythm, assay variability—all impact results! Too many variables!!! #NephJC
How do you adjust ARR interpretation in clinical practice?
⚠️ Meds, salt intake, posture, hypokalemia, circadian rhythm, assay variability—all impact results! Too many variables!!! #NephJC
How do you adjust ARR interpretation in clinical practice?
Aldosterone escape effect:
Classic RAAS blockers can’t fully shut down aldosterone production.
Braxdrostat in the BrightHTN showed SBP reduction, PRA suppresion and no cortisol suppresion #NephJC @nephmadness.bsky.social 2025
Classic RAAS blockers can’t fully shut down aldosterone production.
Braxdrostat in the BrightHTN showed SBP reduction, PRA suppresion and no cortisol suppresion #NephJC @nephmadness.bsky.social 2025
May 27, 2025 at 11:45 PM
Aldosterone escape effect:
Classic RAAS blockers can’t fully shut down aldosterone production.
Braxdrostat in the BrightHTN showed SBP reduction, PRA suppresion and no cortisol suppresion #NephJC @nephmadness.bsky.social 2025
Classic RAAS blockers can’t fully shut down aldosterone production.
Braxdrostat in the BrightHTN showed SBP reduction, PRA suppresion and no cortisol suppresion #NephJC @nephmadness.bsky.social 2025
Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases by Drs. Fioretti, Butler et al.
www.jacc.org/doi/10.1016/...
This review describe the role of aldosterone, steroidal and nonsteroidal MRA and aldosterone synthase inhibitors in cardio-kidney diseases.
www.jacc.org/doi/10.1016/...
This review describe the role of aldosterone, steroidal and nonsteroidal MRA and aldosterone synthase inhibitors in cardio-kidney diseases.
July 31, 2025 at 8:01 PM
Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases by Drs. Fioretti, Butler et al.
www.jacc.org/doi/10.1016/...
This review describe the role of aldosterone, steroidal and nonsteroidal MRA and aldosterone synthase inhibitors in cardio-kidney diseases.
www.jacc.org/doi/10.1016/...
This review describe the role of aldosterone, steroidal and nonsteroidal MRA and aldosterone synthase inhibitors in cardio-kidney diseases.
Recent research shows that even moderate amounts, like someone with a favorite licorice tea or love for Swedish licorice lozenges can trigger changes like blood pressure increases and longer-term changes in aldosterone-to-renin ratio (ARR).
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A low dose of daily licorice intake affects renin, aldosterone, and home blood pressure in a randomized crossover trial
Licorice, through the effects of glycyrrhizic acid (GA), raises blood pressure (BP). The World Health Organization has suggested that 100 mg GA/d woul…
www.sciencedirect.com
May 11, 2024 at 9:22 PM
Recent research shows that even moderate amounts, like someone with a favorite licorice tea or love for Swedish licorice lozenges can trigger changes like blood pressure increases and longer-term changes in aldosterone-to-renin ratio (ARR).
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Aaand it’s official, we have a new antihypertensive class!!!! 🎉🍾🎊
I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent
www.nejm.org/doi/full/10....
I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent
www.nejm.org/doi/full/10....
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone
synthase inhibitor, but data on its efficacy and safety in patients with hypertension
are limited. In this mult...
www.nejm.org
April 23, 2025 at 10:38 PM
Aaand it’s official, we have a new antihypertensive class!!!! 🎉🍾🎊
I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent
www.nejm.org/doi/full/10....
I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent
www.nejm.org/doi/full/10....
BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ
October 15, 2025 at 7:02 PM
BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ
Hypokalemia: Diagnostic algorithm
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
January 26, 2025 at 5:10 AM
Hypokalemia: Diagnostic algorithm
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
Also, if you cannot tolerate stress and are prone to crashing out + the above. Try these tests:
-cortisol
-aldosterone
-17,20-lyase
-17α-hydroxylase
-cortisol
-aldosterone
-17,20-lyase
-17α-hydroxylase
June 17, 2026 at 5:29 AM
Also, if you cannot tolerate stress and are prone to crashing out + the above. Try these tests:
-cortisol
-aldosterone
-17,20-lyase
-17α-hydroxylase
-cortisol
-aldosterone
-17,20-lyase
-17α-hydroxylase
#ThrowbackThursday
Variability of Aldosterone concentration while performing AVS
academic.oup.com/ajh/article/...
#Free #EditorsCHoice
Variability of Aldosterone concentration while performing AVS
academic.oup.com/ajh/article/...
#Free #EditorsCHoice
July 24, 2025 at 3:38 PM
#ThrowbackThursday
Variability of Aldosterone concentration while performing AVS
academic.oup.com/ajh/article/...
#Free #EditorsCHoice
Variability of Aldosterone concentration while performing AVS
academic.oup.com/ajh/article/...
#Free #EditorsCHoice
The Aldosterone Paradox: A Skeetutorial:
a man stands in front of a blackboard with the words it 's paradoxical and yet it works
ALT: a man stands in front of a blackboard with the words it 's paradoxical and yet it works
media.tenor.com
December 31, 2024 at 3:51 AM
The Aldosterone Paradox: A Skeetutorial:
It's been a long journey but today we can share the methods and rationale for the #ACHIEVEtrial (Spiro vs placebo for patients with kidney failure receiving maintenance dialysis) and tomorrow we share the results at #era25
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol - Michael Walsh, David Collister, Martin Gallagher, Patr...
Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. W...
journals.sagepub.com
June 5, 2025 at 7:44 AM
It's been a long journey but today we can share the methods and rationale for the #ACHIEVEtrial (Spiro vs placebo for patients with kidney failure receiving maintenance dialysis) and tomorrow we share the results at #era25
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
The aldosterone synthase inhibitor lorundrostat may be an effective treatment for uncontrolled, treatment-resistant hypertension. Research findings from the Advance-HTN trial are summarized in a new Quick Take video. nej.md/4iUsNRT
#MedSky #CardioSky
#MedSky #CardioSky
May 10, 2025 at 7:02 PM
The aldosterone synthase inhibitor lorundrostat may be an effective treatment for uncontrolled, treatment-resistant hypertension. Research findings from the Advance-HTN trial are summarized in a new Quick Take video. nej.md/4iUsNRT
#MedSky #CardioSky
#MedSky #CardioSky
What neurons drive increased salt intake in response to aldosterone? https://insight.jci.org/articles/view/175087
Silvia Gasparini and colleagues show that HSD2 neurons are required for aldosterone-induced salt intake.
Silvia Gasparini and colleagues show that HSD2 neurons are required for aldosterone-induced salt intake.
December 13, 2024 at 2:34 PM
What neurons drive increased salt intake in response to aldosterone? https://insight.jci.org/articles/view/175087
Silvia Gasparini and colleagues show that HSD2 neurons are required for aldosterone-induced salt intake.
Silvia Gasparini and colleagues show that HSD2 neurons are required for aldosterone-induced salt intake.
The era of ASIs is slowly dawning
www.nejm.org/doi/full/10....
(Yeah spironolactone is just as good and cheaper)
Disclosure: we recruited patients for this one
www.nejm.org/doi/full/10....
(Yeah spironolactone is just as good and cheaper)
Disclosure: we recruited patients for this one
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension | NEJM
Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension.
In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated
systolic blood pr...
www.nejm.org
August 30, 2025 at 2:39 PM
The era of ASIs is slowly dawning
www.nejm.org/doi/full/10....
(Yeah spironolactone is just as good and cheaper)
Disclosure: we recruited patients for this one
www.nejm.org/doi/full/10....
(Yeah spironolactone is just as good and cheaper)
Disclosure: we recruited patients for this one
An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
November 28, 2025 at 3:56 PM
An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
#WeekendReads from the Advance Articles section
Time to retire Aldosterone Suppression Testing?
academic.oup.com/ajh/advance-...
Time to retire Aldosterone Suppression Testing?
academic.oup.com/ajh/advance-...
Is It Time to Retire Aldosterone Suppression Testing?
Abstract. Primary aldosteronism (PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving nonsuppressibility of aldost
academic.oup.com
October 4, 2025 at 2:15 PM
#WeekendReads from the Advance Articles section
Time to retire Aldosterone Suppression Testing?
academic.oup.com/ajh/advance-...
Time to retire Aldosterone Suppression Testing?
academic.oup.com/ajh/advance-...
November 27, 2025 at 11:32 AM
Comprehensive review of aldosterone-targeted therapies: early implementation in resistant hypertension and chronic kidney disease #nephsky
As nephrologists, spironolactone is an old friend, but what about the newer finerenone and aldosterone synthase inhibitors?
academic.oup.com/eurheartj/ad...
As nephrologists, spironolactone is an old friend, but what about the newer finerenone and aldosterone synthase inhibitors?
academic.oup.com/eurheartj/ad...
April 14, 2025 at 12:49 AM
Comprehensive review of aldosterone-targeted therapies: early implementation in resistant hypertension and chronic kidney disease #nephsky
As nephrologists, spironolactone is an old friend, but what about the newer finerenone and aldosterone synthase inhibitors?
academic.oup.com/eurheartj/ad...
As nephrologists, spironolactone is an old friend, but what about the newer finerenone and aldosterone synthase inhibitors?
academic.oup.com/eurheartj/ad...
ICYMI: New content online: Aldosterone synthase inhibitors for the treatment of cardiovascular disease
Aldosterone synthase inhibitors for the treatment of cardiovascular disease
Nature Reviews Endocrinology, Published online: 22 May 2026; doi:10.1038/s41574-026-01259-4Increased levels of aldosterone seem to have a role in treatment-resistant arterial hypertension, hypertension associated with primary aldosteronism and heart failure. This Review examines the evidence regarding this connection and discusses the efficacy and safety of treatment with mineralocorticoid receptor antagonists and with aldosterone synthase inhibitors.
go.nature.com
May 24, 2026 at 9:21 PM
ICYMI: New content online: Aldosterone synthase inhibitors for the treatment of cardiovascular disease