We explored alkyne-functionalized hydrazone photoswitches and enhanced their performance, achieving improved UV resolution, higher photostationary states, and tunable alkyne shifts (up to 34 cm−1), es...

Using a reductive group elimination strategy, heavier alkyne (LEEL; E = Sn, Pb) complexes of Ni0 are accessed. In contrast to classical alkyne coordination, these systems are best described as σ-comp...

Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...

The formation of polyynes with an odd number of conjugated triple bonds is challenging, particularly for complex architectures since most established methods rely on irreversible C–C bond-forming rea...

The reaction between NHC-supported (NHC = N-heterocyclic carbene) gold(i) trimethylsilylacetylide complexes with NHC gold(i) hydroxide species renders different symmetrical homobimetallic Au complexes...

Carbonyl–olefin and carbonyl–alkyne metathesis enable atom-economic C–C bond formation beyond classical olefin metathesis. This review highlights recent advances in photochemical, Lewis-acid, Brønste...

Herein, we report the use of alkyne benzannulation on zigzag-edged dibenzochrysene derivatives to extend the conjugation and reduce their bandgap. Unexpectedly, the ring closure reaction takes place ...

This work demonstrates the synthesis of cationic Pt(II) η3-cycloallyl complexes, and experimental and computational studies show a ligand bite-angle dependence of their formation rates. The reactivit...

A series of hexa- and nonafluoroalkoxy molybdenum alkylidynes featuring ancillary imidazolin-2-imide, phosphoraneimide, and siloxide ligands has been synthesized and characterized. The siloxy-substit...

The redox neutral carbometallation of a phospha-alkyne using the dimeric indium(I) compound (InTer)2 is reported. This reaction affords a mono-coordinate indium(I) compound that can reversibly extrud...

Alkyne- and alkene-tethered acyl fluorides undergo intramolecular carbofluorination via fluoride recycling using catalytic TrBF4. Excellent stereoselectivity is observed for the alkyne addition, enabling access to novel fluorinated indan-2-ones (all ≥95:5 E/Z) and cyclopentan-2-ones (85:15 E/Z). Fluorinated chroman-2-ones and tertiary alkyl fluorides can also be synthesized using this method, comparing favorably to previously reported protocols that employ expensive metal catalysts under harsher conditions.

To quantify the role of CME for sorting lipids at the plasma membrane, we optimized our recently developed lipid imaging workflow19 for super-resolution STED microscopy. The lipid imaging approach relies on near-native bifunctional lipids, which are modified with a diazirine and alkyne moiety. The diazirine can be photochemically cross-linked to neighbouring biomolecules, while the alkyne is used for labelling by click chemistry. These probes closely resemble native lipids with regard to their metabolism and biophysical properties. The combined effect of the modifications is approximately equivalent to the introduction of one additional double bond19,24,25 (Extended Data Fig. 1). Briefly, bifunctional lipids were loaded into the outer leaflet of the plasma membrane and fixed via subsequent ultraviolet (UV) light and chemical cross-linking (Fig. 1a). To restrict lipid localization to the plasma membrane, lipids were UV cross-linked shortly after lipid loading, and cells were fixed chemically using a protocol adapted from a previous study26 to ensure conservation of CCP ultrastructure. UV cross-linking time was minimized using high-powered light-emitting diodes (LEDs) at 365 nm with a collimation lens to maximize photon flux (Extended Data Fig. 2a–c and Supplementary Data 1). Subsequently, samples were permeabilized to remove non-cross-linked probes and to allow for immunolabelling of...

An alkyne-tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the...