Alkynes of trouble
Organohelium chemistry.
ref: J. Am. Chem. Soc. 1988, 110, 4, 1298–1299
#chemsky ⚗️🧪
pubs.acs.org/doi/pdf/10.1...
ref: J. Am. Chem. Soc. 1988, 110, 4, 1298–1299
#chemsky ⚗️🧪
pubs.acs.org/doi/pdf/10.1...
November 20, 2024 at 11:08 PM
Alkynes of trouble
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 25, 2026 at 2:03 PM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 24, 2026 at 7:00 AM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Water you saying? This is alkynes of funny
March 22, 2026 at 1:24 PM
Water you saying? This is alkynes of funny
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 24, 2026 at 7:01 AM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Wear this shirt to meet alkynes of people– maybe someone you’ll click with!
March 31, 2026 at 1:17 AM
Wear this shirt to meet alkynes of people– maybe someone you’ll click with!
Alkynes of Spirits
December 27, 2025 at 10:17 PM
Alkynes of Spirits
Nature research paper: Aluminium redox catalysis enables cyclotrimerization of alkynes
go.nature.com/4raxrQF
go.nature.com/4raxrQF
Aluminium redox catalysis enables cyclotrimerization of alkynes - Nature
Aluminium redox catalysis is achieved with a low-valent aluminium species, carbazolylaluminylene, enabling cyclotrimerization of alkynes and producing diverse benzene derivatives.
go.nature.com
February 11, 2026 at 6:38 PM
Nature research paper: Aluminium redox catalysis enables cyclotrimerization of alkynes
go.nature.com/4raxrQF
go.nature.com/4raxrQF
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 23, 2026 at 1:26 AM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Researchers have devised an aluminum complex that undergoes a full catalytic cycle. The metal switches between two different oxidation states to assemble substituted benzene rings from alkynes. cen.acs.org/synthesis/ca...
#chemsky 🧪
#chemsky 🧪
February 18, 2026 at 12:45 PM
Researchers have devised an aluminum complex that undergoes a full catalytic cycle. The metal switches between two different oxidation states to assemble substituted benzene rings from alkynes. cen.acs.org/synthesis/ca...
#chemsky 🧪
#chemsky 🧪
May 6, 2025 at 5:49 AM
How to catalytically cyclize alkyl species onto alkynes? Just add a pinch of bismuth! Read about our findings in controlled radical reactions catalyzed by well-defined manganese- bismuth heterobimetallic complexes, just published in ACS Catalysis @pubs.acs.org: pubs.acs.org/doi/10.1021/...
Bismuth Radical Catalysis: Thermally Induced Intramolecular C(sp3)–C(sp) Cyclization of Unactivated Alkyl Iodides and Alkynes
Bismuth radical chemistry has attracted increased interest in recent years. Here, we report a series of bismuth–manganese complexes that catalyze the intramolecular redox-neutral coupling of alkyl iod...
pubs.acs.org
August 13, 2025 at 3:27 PM
How to catalytically cyclize alkyl species onto alkynes? Just add a pinch of bismuth! Read about our findings in controlled radical reactions catalyzed by well-defined manganese- bismuth heterobimetallic complexes, just published in ACS Catalysis @pubs.acs.org: pubs.acs.org/doi/10.1021/...
Congrats to Elliott, @hls111.bsky.social, Olivera, Patrick, Alexander and Daniel! Ligand Design Enables the Palladium-Catalyzed Intermolecular Carbochlorocarbonylation of Alkynes and Cyclopentenone Formation @jacs.acspublications.org pubs.acs.org/doi/full/10....
August 6, 2025 at 8:51 PM
Congrats to Elliott, @hls111.bsky.social, Olivera, Patrick, Alexander and Daniel! Ligand Design Enables the Palladium-Catalyzed Intermolecular Carbochlorocarbonylation of Alkynes and Cyclopentenone Formation @jacs.acspublications.org pubs.acs.org/doi/full/10....
Congratulations to Tanmay, Asma and Abdulrahman, whose work on the Catalytic Stereoselective Intermolecular Fluoroacylation of Unactivated Alkynes via C–F Bond Reconstruction has been published in Org Lett!
@astrazeneca.com @bathchem.bsky.social
pubs.acs.org/orlef7/artic...
@astrazeneca.com @bathchem.bsky.social
pubs.acs.org/orlef7/artic...
September 27, 2026 at 8:24 PM
Congratulations to Tanmay, Asma and Abdulrahman, whose work on the Catalytic Stereoselective Intermolecular Fluoroacylation of Unactivated Alkynes via C–F Bond Reconstruction has been published in Org Lett!
@astrazeneca.com @bathchem.bsky.social
pubs.acs.org/orlef7/artic...
@astrazeneca.com @bathchem.bsky.social
pubs.acs.org/orlef7/artic...
Copper-Catalyzed Cyclopropenation of Alkynes with Difluoromethyl Carbene
May 7, 2025 at 6:58 AM
Copper-Catalyzed Cyclopropenation of Alkynes with Difluoromethyl Carbene
Neat! I wonder whether in Yiddish Chemistry, alkanes are Litvish and alkynes are Poylish?
May 27, 2026 at 2:53 AM
Neat! I wonder whether in Yiddish Chemistry, alkanes are Litvish and alkynes are Poylish?
Over 10 years in the making, finally live!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
A Half Century of the Sonogashira Reaction
Conjugated alkynes are valuable intermediates in the synthesis of natural products, agrochemicals, pharmaceuticals, fine chemicals, and organic molecular materials. Since its introduction in 1975, th....
onlinelibrary.wiley.com
January 3, 2025 at 9:24 PM
Over 10 years in the making, finally live!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Inspired 💡 by Prof. Alois Fürstner's brilliant lecture today on gem-Hydrogenation of alkynes showcasing mechanistic understanding and elegant catalyst design for a long inconceived mode of hydrogen delivery! #OrganicChemistry #Catalysis @maxplanck.de
April 10, 2025 at 5:37 PM
Inspired 💡 by Prof. Alois Fürstner's brilliant lecture today on gem-Hydrogenation of alkynes showcasing mechanistic understanding and elegant catalyst design for a long inconceived mode of hydrogen delivery! #OrganicChemistry #Catalysis @maxplanck.de
Our democratically elected #paperofthemonth is Lalic's work on the Selective Synthesis of Z‑Michael Acceptors via Hydroalkylation of Conjugated Alkynes.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Selective Synthesis of Z-Michael Acceptors via Hydroalkylation of Conjugated Alkynes
Hydroalkylation of terminal alkynes is a powerful approach to the synthesis of disubstituted alkenes. However, its application is largely unexplored in the synthesis of α,β-unsaturated carbonyls, whic...
pubs.acs.org
January 20, 2025 at 8:43 AM
Our democratically elected #paperofthemonth is Lalic's work on the Selective Synthesis of Z‑Michael Acceptors via Hydroalkylation of Conjugated Alkynes.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
www.organic-chemistry.org/abstracts/li...
A catalytic coupling of terminal alkynes with alkylboranes and organohalides enables
A catalytic coupling of terminal alkynes with alkylboranes and organohalides enables
September 25, 2026 at 9:47 AM
www.organic-chemistry.org/abstracts/li...
A catalytic coupling of terminal alkynes with alkylboranes and organohalides enables
A catalytic coupling of terminal alkynes with alkylboranes and organohalides enables
Together with @hering-lab.bsky.social at @likat.bsky.social we report on titanacycles doped with 1 or 2 P-atoms. Synthesized via CA between alkynes and phosphinidene/diphosphene Ti precursors, this approach echoes Stephan’s work on Zr-congeners but with key differences.
doi.org/10.1002/zaac...
doi.org/10.1002/zaac...
On Phosphatitanacycles
Titanocene phosphinidenes react with terminal alkynes in formal [2 + 2] cycloadditions to give unsaturated [C2PTi] metallcycles. Diphosphene complexes in combination with aryl-substituted alkynes rea...
doi.org
April 22, 2026 at 7:27 AM
Together with @hering-lab.bsky.social at @likat.bsky.social we report on titanacycles doped with 1 or 2 P-atoms. Synthesized via CA between alkynes and phosphinidene/diphosphene Ti precursors, this approach echoes Stephan’s work on Zr-congeners but with key differences.
doi.org/10.1002/zaac...
doi.org/10.1002/zaac...
Check out our latest collaborative work with the Baik and Wirth groups in @chemicalscience.rsc.org
pubs.rsc.org/en/Content/A...
pubs.rsc.org/en/Content/A...
Oxidative Rearrangement of Alkynes to chiral α-Arylalkanoic Esters
Chiral α-arylalkanoic esters, valued as anti-inflammatory agents, are synthesised through an enantioselective oxidative rearrangement of alkynes under green, metal-free conditions. This study achieves...
pubs.rsc.org
November 24, 2025 at 5:54 PM
Check out our latest collaborative work with the Baik and Wirth groups in @chemicalscience.rsc.org
pubs.rsc.org/en/Content/A...
pubs.rsc.org/en/Content/A...
Now online:
Article by Xiao-Song Xue, Zhi-Tao He & co-workers
Three-dimensional divergent hydroheteroarylation of internal alkynes with indolizines
www.nature.com/articles/s44... ($)
#Chemsky
Article by Xiao-Song Xue, Zhi-Tao He & co-workers
Three-dimensional divergent hydroheteroarylation of internal alkynes with indolizines
www.nature.com/articles/s44... ($)
#Chemsky
Three-dimensional divergent hydroheteroarylation of internal alkynes with indolizines - Nature Synthesis
The hydroheteroarylation of internal alkynes with indolizines via Pd and Rh catalysis is reported. This catalyst-controlled three-dimensional divergent protocol produces eight types of diaryl allyl sk...
www.nature.com
September 3, 2025 at 12:39 PM
Now online:
Article by Xiao-Song Xue, Zhi-Tao He & co-workers
Three-dimensional divergent hydroheteroarylation of internal alkynes with indolizines
www.nature.com/articles/s44... ($)
#Chemsky
Article by Xiao-Song Xue, Zhi-Tao He & co-workers
Three-dimensional divergent hydroheteroarylation of internal alkynes with indolizines
www.nature.com/articles/s44... ($)
#Chemsky
Paper alert: Rachel D. developed a 4-component 2+2+1+1 route to dihydropyrimidines, leveraging my favorite diazatitanacycle synthetic intermediate! Out now in chemcomm: pubs.rsc.org/en/Content/A... Congrats, Rachel, who got this out just in time for her PhD defense in a few weeks!
![[2+2+1+1] route to dihydropyrimidines from alkynes, nitriles, Ti imidos, and aldehydes](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cqaphaedba5jcldb2ozkccab/bafkreieeqzzceehgq25lslo764swiuerjib7foxpbx3ahsyyi3v5l2r27q)
May 15, 2025 at 6:59 PM
Paper alert: Rachel D. developed a 4-component 2+2+1+1 route to dihydropyrimidines, leveraging my favorite diazatitanacycle synthetic intermediate! Out now in chemcomm: pubs.rsc.org/en/Content/A... Congrats, Rachel, who got this out just in time for her PhD defense in a few weeks!