#assembloids
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ichajaroslav.bsky.social
I enjoyed reading this paper from Wittbrodt lab on retinal lamination, using in vitro approach of retinal organoids/assembloids.

It adds to what we know about need for polarity cues in the developing retina and draws a parallel to invertebrate compound eye development.
www.cell.com/iscience/ful...
October 13, 2026 at 10:01 AM
biorxivpreprint.bsky.social
Self-Exciting Population Event Models Reveal Abnormal Temporal Amplification in MAPT-Mutant Human Brain Assembloids https://www.biorxiv.org/content/10.64898/2026.10.01.756068v1
October 8, 2026 at 7:15 PM
biorxiv-neursci.bsky.social
Self-Exciting Population Event Models Reveal Abnormal Temporal Amplification in MAPT-Mutant Human Brain Assembloids https://www.biorxiv.org/content/10.64898/2026.10.01.756068v1
October 8, 2026 at 7:15 PM
ichajaroslav.bsky.social
The high throughput time-lapse imaging of assembloids was done on Bruker Luxendo Acquifer IM microscope. This assay benefits from the static stage of the microscope - the 96 well plate doesn't move during the acquisition (the optical unit moves instead).
microscope: www.bruker.com/en/products-...
Acquifer IM
www.bruker.com
October 13, 2026 at 10:02 AM
janellebelle.bsky.social
Human brain assembloids as a model of anaesthetic-induced neural dynamics in vitro

www.sciencedirect.com/science/arti...
www.sciencedirect.com
October 6, 2026 at 3:26 AM
profharley.bsky.social
Yes. And assembloids made up of heterogenous cell populations. Those pubs are coming out soon
October 5, 2026 at 4:40 AM
comiteproanima.bsky.social
NAMs around the world 📌 News of the week 📌 by Pro Anima

Global regulators call for advancing NAMs for human medicines, Producing stem cells on a large scale, AI to interpret in vitro data, Brain assembloids to study anesthesia, and more

Read more: www.proanima.fr/en/blog/glob...
October 9, 2026 at 7:16 AM
biorxiv-neursci.bsky.social
Human cerebral assembloids as a model to study the interaction of glioblastoma with resident glial cells https://www.biorxiv.org/content/10.64898/2026.09.29.755236v1
October 2, 2026 at 7:16 AM
biorxivpreprint.bsky.social
Human cerebral assembloids as a model to study the interaction of glioblastoma with resident glial cells https://www.biorxiv.org/content/10.64898/2026.09.29.755236v1
October 2, 2026 at 7:16 AM
rridrobot.bsky.social
RRID:AB_10979409 from @thermofishersci.bsky.social was used by authors in their Neuron paper. RRIDs improve reproducibility in scientific research. #STMpublishing #ReproducibleResearch #OpenScience
Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids
Read the full paper: Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids
doi.org
October 2, 2026 at 7:01 AM
philoneurosci.bsky.social
#Autism -associated SCN2A deficiency disrupts cortico-striatal circuitry in #human #brain #assembloids: Neuron www.cell.com/neuron/fullt...
Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids
Chen et al. show that SCN2A protein-truncating variants disrupt cortico-striatal circuitry while increasing neuronal excitability in human brain assembloids. CAV-2-mediated SCN2A restoration mitigates...
www.cell.com
September 30, 2026 at 3:07 PM
cp-neuron.bsky.social
Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids
Chen et al. show that SCN2A protein-truncating variants disrupt cortico-striatal circuitry while increasing neuronal excitability in human brain assembloids. CAV-2-mediated SCN2A restoration mitigates intrinsic hyperexcitability and circuit deficits, supporting targeted gene replacement as a potential therapeutic strategy for SCN2A-related neurodevelopmental disorders.
dlvr.it
September 30, 2026 at 3:23 PM
uclastemcell.bsky.social
Hundreds of thousands of people undergo general anesthesia every day, yet exactly how it produces unconsciousness is still not fully understood. 🧠💤 UCLA scientists have created a new way to study that process using human stem cell-derived brain models called assembloids. 🔗 https://ow.ly/KHJi50ZTIFY
Representative image of a developing human cortex-like organoid.
October 1, 2026 at 8:20 PM
solsten.bsky.social
You’ll be happy to know they actually are working on it. Advancements coming fast these days

www.cell.com/cell-stem-ce...
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling
Recapitulating the self-assembly of kidney progenitors, Huang, Medina, He, Zeng, and colleagues have developed mouse and human kidney progenitor assembloids, exhibiting enhanced cellular complexity, s...
www.cell.com
September 29, 2026 at 9:39 PM
sergiuppasca.bsky.social
The 5th edition of the CSHL meeting on neural #organoids, #assembloids & human development is approaching!
Since the first meeting in 2017, this has become a special forum for the field.
This edition promises outstanding speakers, strong trainee engagement & the perfect setting to hear the latest
cshlmeetings.bsky.social CSHL Meetings @cshlmeetings.bsky.social · 15d
The abstract deadline for the Development & 3D Modeling of the Human Brain meeting has just been extended to October 9th! Register to submit your abstract for #cshlbrain here: bit.ly/4hQH055

@sergiuppasca.bsky.social
Development & 3D Modeling of the Human Brain
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
bit.ly
September 28, 2026 at 6:51 PM
jeroenbugter.bsky.social
A recurring trade-off: every layer of complexity (co-culture, engineered matrix, assembloids, transplantation) brings you closer to the tissue but costs experimental control. The most sophisticated system is not always the most informative.
September 25, 2026 at 12:09 PM
biorxiv-devbio.bsky.social
Modeling human embryonic adrenogenesis in pluripotentstem cell-derived corticomedullar-like assembloids https://www.biorxiv.org/content/10.64898/2026.09.23.753945v1
September 24, 2026 at 6:30 PM
biorxivpreprint.bsky.social
Modeling human embryonic adrenogenesis in pluripotentstem cell-derived corticomedullar-like assembloids https://www.biorxiv.org/content/10.64898/2026.09.23.753945v1
September 24, 2026 at 6:30 PM
keck.usc.edu
Can #StemCell based organoids and assembloids finally give scientists a real model for kidney disease? Zhongwei Li, PhD at USC Stem Cell just got a $240,000 PKD Foundation grant to find out. https://bit.ly/3Vh8AQg

📸 Carrie Zhang/Li Lab/USC Stem Cell
A lab-grown kidney organoid made of human collecting duct cells shows elongated tubules—the segment of the kidney primarily affected by the incurable genetic condition called autosomal recessive polycystic kidney disease (ARPKD).
September 25, 2026 at 10:34 PM
jeroenbugter.bsky.social
You've established your organoid system. Now what?

Our new Tutorial in @natureprotocols.bsky.social, with Simon Schafer & Roland Rad, is about that next step: matching your biological question to the right technique and protocol 🧫

🔗 rdcu.be/ig3BwFn4vY7a
Overview of organoid applications. Across the top are six biological questions: cell fate decisions, cell–cell communication, genetic disease mechanisms, cell–microbe interactions, species evolution and therapeutic questions. Below them are the stages of an experiment: generating the organoid model; increasing complexity through matrix engineering, vascularisation, microbe co-culture, microfluidics, assembloids, orthotopic transplantation and niche co-culture; manipulation through genetic engineering, CRISPR and pharmacological screening, selective cell ablation and isolating sub-populations; and read-outs at the molecular, cellular and organism level.
September 25, 2026 at 12:09 PM
jeroenbugter.bsky.social
For each application, from cell–cell communication to genetic disease modelling and host–microbe interactions, we compare the available techniques side by side, including what each can and cannot tell you.
Toolbox to study cell–cell communication in organoids: (a) organoid reconstitution from single stem cells or stem–niche cell doublets; (b) organ-on-a-chip with tissue-resident immune and mesenchymal cells; (c) varying the extracellular matrix, such as Matrigel versus collagen I; (d) hybrid organoids of cancer and normal cells; (e) assembloids fusing different brain regions; (f) xenotransplantation of organoids with immune cells into mice. Strategies for genetic disease modelling. (a) From adult stem cells: healthy organoids can be engineered to carry a disease mutation ("genetic mimicry"), and patient-derived disease organoids ("patient avatars") can be genetically corrected. (b) The same two strategies applied to pluripotent stem cells, which are edited before being differentiated into organoids. Methods to expose organoids to bacteria, viruses and parasites, with pros and cons: addition during passage (simple, but exposes both sides and gives limited control); monolayers (straightforward, but short-term and prone to stress artefacts); apical-out organoids (straightforward, but short-term only); microinjection (precise and allows long-term culture, but laborious and low-throughput); Transwell systems (oxygen control, but short-term and low-throughput); and organ-on-a-chip (control and flow with long-term culture, but technically demanding and more expensive).
September 25, 2026 at 12:09 PM
sergiuppasca.bsky.social
Human neural #assembloids and #organoids have opened new ways to study development in vitro, but they also have important limitations.
September 16, 2026 at 8:28 PM
organoidchips.bsky.social
#organoids #organonachip #assembloids #microphysiologicalsystems #advancedcellbiology #NAMS
September 15, 2026 at 9:38 AM
ascbiology.bsky.social
Ready to take your organoid models further?

Explore liver assembloids, synthetic matrices, and practical approaches for building better disease models.

Sept. 14 | 10 am ET

Register:
https://www.ascb.org/ascb-meetings/from-organoids-to-assembloids-building-better-models-of-human-disease-session-2/
From Organoids to Assembloids: Building Better Models of Human Disease - Session 2 - ASCB
Standard organoid cultures have transformed disease research — but they still struggle to capture the multi-cell-type architecture that drives disease progression in vivo. What You’ll Learn Join Dr. Meritxell Huch and Didarul Bhuiyan, PhD, as they walk you through two approaches to building better organoid models. Dr. Huch will cover the liver assembloids her team…
www.ascb.org
September 11, 2026 at 5:45 PM
sergiuppasca.bsky.social
Mornings are devoted to lectures, while afternoons are spent at the bench: going from building assembloids to imaging them and recording their electrical activity. Throughout the week, students also work together in small groups on a project. This year, by popular demand, we focused on assembloids
September 10, 2026 at 2:52 AM