Candida auris colonizes metabolically diverse host niches and modulates immunity to its advantage. This study shows that carbon source availability regulates C. auris adhesion and cell morphology, the...

On Sunday, 4th May 2025, a red Toyota Auris taxi registered CN14 ZFE passed a cyclist extremely close on the A644 Huddersfield Road in Dewsbury.

Gert Blomquist fick cochleaimplantat 2012. Nu vill Försäkringskassan återta hans handikappersättning retroaktivt för att de anser att hans resultat på hörseltesten är för bra. Detta trots att han fort...

Clinicians must maintain high suspicion for Candida auris endocarditis in ICU patients; rapid fungal identification and cardiology consultation are essential for optimal outcomes.

View abstract Background:Candida auris is a globally emerging, multidrug-resistant pathogen characterized by extreme environmental persistence and resistance to standard hospital disinfectants. Our ICU faced an endemic outbreak that lasted for 30 months, which was resistant to standard infection prevention and control (IPC) bundles.Objective:To evaluate the efficacy of a radical, multi-sectoral “Unit Reset” protocol involving total operational decanting, mechanical disassembly, and inventory disposal after incremental IPC strategies were exhausted.Methods:We executed a 120-hour “Unit Reset” in February 2026. The intervention comprised: (1) transferring all patients to a temporary satellite site; (2) total disposal of all pharmaceutical and disposable inventories; (3) structural remediation; and (4) dual-team mechanical disinfection with 5,000 ppm hypochlorite supplemented by 18% automated hydrogen peroxide vapor (HPV).Results:Over the 30-month endemic period, C. auris acquisition rates escalated despite high compliance with standard IPC bundles. Environmental surveillance rounds identified persistent reservoirs on high-touch surfaces that the routine cleaning protocols missed. Following the 120-hour Unit Reset, the ICU was reopened to admissions. During the subsequent 16-week active surveillance window, zero new clinical acquisitions or screening-positive cases were detected, representing the first sustained interruption of transmission since August 2023.Conclusions:When C. auris achieves deep environmental sequestration within deteriorated medical infrastructure or complex equipment housings, incremental “enhanced cleaning” protocols may fail due to biofilm shielding. A radical, coordinated institutional reset can terminate entrenched nosocomial transmission when standard IPC bundles reach their limits.

Candida auris colonizes metabolically diverse host niches and modulates immunity to its advantage. This study shows that carbon source availability regulates C. auris adhesion and cell morphology, the...

City St George’s researchers, working with the University of Exeter, have discovered an unexpected new mechanism that allows the deadly fungal pathogen Candida auris to survive antifungal treatment.

For most of mammalian evolutionary history, fungi posed a negligible threat to mammals. While devastating to plants and ectothermic animals, and causing agricultural catastrophes, fungal pathogens were largely unable to breach the defenses of warm-blooded hosts (1). With a core temperature of approximately 37°C against a global mean temperature of roughly 15°C, mammals maintain a thermal gradient that only a fraction of the estimated 3–5 million fungal species can overcome (2, 3). A highly efficient adaptive immune system serves as a second line of defense. With these “twin pillars of protection” intact, mammals remain remarkably resistant to fungal disease (4). Of the approximately 148,000 described fungal species, only 300–400 (0.3–0.4%) are currently capable of infecting humans, and most of these are opportunistic pathogens that primarily threaten immunocompromised individuals (5).

New research has revealed an unexpected new mechanism through which the killer fungus Candida auris is resisting antifungal drug treatment. A team led by the University of Exeter and City St George’s, University of London,

Agency flags 19 pathogens, including four drug-resistant bugs for its 'urgent threats' list

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