PhD Project - (MRC NW-DMS) Uncovering plasmid-driven metabolic vulnerabilities to tackle multidrug resistant pathogens at The University of Manchester, listed on FindAPhD.com

Many bacterial pathogens rely on tightly regulated gene expression to cause disease, making virulence pathways attractive targets for new therapies. Diffusible signal factors (DSFs) are communication molecules that can suppress the virulence of several enteric pathogens, but their sources in the gut have not been well defined. Here, we identify gut-associated bacteria that produce the DSF molecule cis-2-tetradecenoic acid, capable of strongly repressing virulence in multiple enteric pathogens. Additionally, our work substantially expands the distribution of bacteria with the genetic capacity for DSF production, broadening the pool of candidate signal sources and paving the way for future discoveries in microbial communication.

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U2OS cell expressing Lact-C2-mCherry (yellow) infected by GFP-expressing Coxiella burnetii (pink)

Agency flags 19 pathogens, including four drug-resistant bugs for its 'urgent threats' list

Escape a space nightmare as the sole survivor of an alien infestation. Search for clues and solve puzzles as you avoid deadly encounters with zombies, mutants, robots and unseen alien pathogens. Find ...