#beta-oxidation
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boshen.github.io
Announcing Oxlint Beta: oxc.rs/blog/2025-03...
The JavaScript Oxidation Compiler
A collection of high-performance JavaScript tools written in Rust
oxc.rs
March 16, 2025 at 3:02 AM
johnrubinstein.bsky.social
EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment.
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
A) Diagram showing how EtfD transfers electrons from beta oxidation to the menaquinol pool in the membrane, linking beta oxidation to oxidative phosphorylation in mycobacteria. B) A growth curve showing the Mycobacterium smegmatis lacking EtfD can grow when glucose is provided as the carbon source, but has a slight growth delay. Complementing the ∆etfD strain with M. tuberculosis on a plasmid rescues the defect. C) A growth curve showing that ∆etfD M. smegmatis cannot grow on medium where the fatty acid oleic acid is the only carbon source. A plasmid with with M. tuberculosis EtfD rescues the defect.
May 16, 2025 at 2:30 PM
joensuulab.bsky.social
🎉 Our discovery opens up exciting new research avenues for supporting healthy brain aging, and treating other metabolic brain disorders. 3/3 #raredisease #mitochondria #neuronalenergy #fattyacids #beta-oxidation #HSP #SPG #metabolism #lipids
October 1, 2025 at 4:11 AM
freddietheodoulou.bsky.social
Here, @proteomis.bsky.social used TMT and label-free #proteomics to analyse @johnathan-n.bsky.social's omega-3 Camelina lines: beta-oxidation and proteasome ⬆️, TAG biosynthesis and seed storage proteins ⬇️ cf. WT. We also estimated pathway enzyme stoichiometry with iBAQ
July 13, 2026 at 9:27 PM
johnrubinstein.bsky.social
Out now in EMBO J ahead of World #TB day!
Our friends at the TB Drug Accelerator identified EtfD as a high-priority target for fast acting treatments so @courbongautier.bsky.social jumped into action.
Our EtfD assay & struct are already being used to help find new therapeutics
tinyurl.com/3cb2j5k9
On the left a light blue density map shows the structure of EtfD in a model membrane in orange. On the right, a schematic shows the path of electrons from beta-oxidation going ETF (the electron transfer flavoprotein) through four iron-sulfur clusters and a heme to reduce menaquinone in the EtfD structure.
March 17, 2026 at 3:39 PM
freddietheodoulou.bsky.social
At long last, a genetically encoded sensor for acetyl-CoA (shame I no longer work on beta-oxidation!)
January 28, 2025 at 5:26 PM
drsarahballantyne.bsky.social
Orange foods are abundant in alpha & beta-carotene, which serve as precursors to vitamin A, essential for vision, immune function & skin health.

These phytonutrients also support cardiovascular health by reducing cholesterol oxidation & improving blood vessel function.
October 3, 2025 at 5:16 PM
shematologist.medsky.social
Hemoglobin M disease, on the other hand is due to a defect in hemoglobin which can be in the alpha, beta, or gamma chain. These defects lead to structural alteration of the heme pocket leading to spontaneous oxidation of Fe++.
8/n
November 18, 2024 at 7:38 PM
shechnerlab.bsky.social
TOP FIVE METABOLIC PATHWAYS
…Based on whether they sound like the name of an old-school anime:

5. The Pentose-Phosphate Shunt

4. Peptidoglycan Degradation

3. Fatty Acid Beta-Oxidation

2. The Dark Reactions of the Calvin Cycle

1. Gluconeogenesis
December 31, 2024 at 6:38 PM
aliciakowaltowski.bsky.social
Very excited to present our latest paper, which shows that selective estrogen beta activation strongly protects against dyslipidemia in a rat menopause model.

onlinelibrary.wiley.com/doi/10.1002/...
Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl-CoA levels, leading to reduce...
onlinelibrary.wiley.com
July 20, 2026 at 9:38 AM
seanwhiter.bsky.social
(Fruktolyse) - Triglyceride ebenfalls über Beta-Oxidation der Fettsäuren und Phosphorylierung des Glycerins in den Citratzyklus eingeschleust werden. Und danach wird es richtig kompliziert mit ATP (einfach) und Reduktionsäquivalenten.
January 7, 2025 at 5:45 PM
jxbotany.bsky.social
🧬🍃 SPECIAL ISSUE REVIEW 🍃🧬

Salinas et al explore the intricate role of salicylic acid in development, senescence, nutrition and defense 🛡️

🔗 doi.org/10.1093/jxb/...

#PlantScience 🧪
Figure 1 of Salinas et al: Regulatory network of salicylic acid (SA) biosynthesis. The figure depicts the well-known iso-chorismate (IC) pathway of SA synthesis, alongside the less extensively studied beta-oxidation and phenylalanine lyase (PAL) pathway. It illustrates the recently described genetic regulation controlling these pathways. The evidence supporting these interactions ranges from direct evidence including genetic studies, biochemical assays, and transcriptomic analyses. It should be noted that while the figure incorporates evidence from various species, specific regulatory interactions may vary among different plant species. The most highly connected nodes, the ICS1, EDS5, and SARD1 genes, underscore their crucial roles in SA synthesis and regulation. ICS1 and EDS5 are the rate-limiting enzymes of SA biosynthesis in the IC pathway, which is the main pathway in Arabidopsis thaliana, while SARD1 is a key regulator of the network.
May 22, 2025 at 4:25 PM
isogg.bsky.social
“Our data suggests that improving beta-oxidation efficiency can decelerate bioenergetic aging and disease progression. The estimated treatment effects of targeting.” #DNA #Epigenetics #isogg #Alzheimers

www.nature.com/articles/s41...
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease - Nature Communications
Bioenergetic capacity, the ability to maintain energy balance under stress, can be monitored using blood acylcarnitine profiles. Improving this capacity may slow Alzheimer’s disease progression.
www.nature.com
March 29, 2025 at 1:42 PM
joensuulab.bsky.social
myristic, palmitic and stearic acids, that neurons use for beta oxidation energy at rest and especially during high neuronal activity (www.nature.com/articles/s42...). This endogenous fatty acid pathway provides ~20% of total neuronal energy at rest, even at hyperglycemic conditions. 2/3
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism
Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.
www.nature.com
December 17, 2025 at 10:05 AM
drjwdietrich.bsky.social
Detailausschnitt aus der Stoffwechselkarte "Biochemical Pathways" von Gerhard Michal. Man sieht u. a. die Stoffwechselpfade des Krebs-Zyklus, des Harnstoffzyklus und der Beta-Oxidation.
November 2, 2025 at 9:10 AM
dfit95.bsky.social
No beta oxidation? Damn
October 30, 2025 at 11:41 PM
biorxivpreprint.bsky.social
Synthesis of stable isotope labeled analogs of phytanic acid for separate and combined tracing of alpha-, beta- and omega-oxidation https://www.biorxiv.org/content/10.1101/2025.11.24.689497v1
November 27, 2025 at 11:45 PM
labbarrow.bsky.social
Sharing our newest publication where we show that the brown fat maintenance regulatory factor Nipsnap1 directly interacts with the mitochondrial beta oxidation machinery to regulate lipid energy homeostasis! Learn more here: jn.nutrition.org/article/S002...
The Mitochondrial Brown Adipose Tissue Maintenance Factor Nipsnap1 Interfaces Directly With the β-Oxidation Protein Machinery in Rodents
The activation of brown adipose tissue (BAT) is associated with improved metabolic health in humans. We previously identified the mitochondrial protein Nipsnap1 as a novel regulatory factor that integ...
jn.nutrition.org
June 23, 2025 at 3:35 PM
parlei.bsky.social
Tänk när du läste metabolismen, förstod hur beta-oxidation, glukoneogenes, vitamin B1, krebs, njurbarken... allt hängde ihop. Tänk på den "wow, det här är så oerhört *coolt!!* känslan. Du skulle få samma känsla innan du var halvvägs igenom problemet, just började förstå golfströmmens hydrodynamik...
November 8, 2025 at 7:36 AM
jblainefoster.bsky.social
Giving people CGMs is just a shiny new way to say “obesity is when eat bad” and the science unequivocally shows it’s more complicated than that! GLP-1s actually address how complicated it is!
A diagram of GLP-1 effects Gastrointestinal: slowed gastric emptying/GI motility and increased acid secretion Pancreas: increased insulin and beta cells, decreased glucagon Liver: decreased hepatic glucose production Adipose: increased lyposis, FFA synthesis, and glucose uptake Muscle: increased glucose oxidation and glycogen synthesis Kidney: increased natriuresis Heart: decreased BP, increased HR, contractility, and cardioprotection Brain: decreased appetite, increased satiety and energy expenditure
April 12, 2025 at 6:59 PM
tallcuppajoe.bsky.social
Data wranglers, I need some help.

I have metabolic pathways with this kind of encoding

oleate β-oxidation

(<i>S</i>)-propane-1,2-diol degradation

How do I tell R to interpret the text so I get a oleate β-oxidation and 𝘚-propane-1,2-diol degradation? I'm not having luck with stack overflow
March 27, 2024 at 7:59 PM
matteo-calcagnile.bsky.social
We found that Pirin, a redox-sensitive modulator of β-oxidation in Streptomyces, generates radicals as a signal to activate antioxidant systems and interacts with CatR, the repressor of catalase

Evolutionary conservation of redox crosstalk?🔬✨

www.sciencedirect.com/science/arti...
Pirin, a redox-sensitive modulator of beta-oxidation, generates hydroxyl radicals and interacts with CatR, the transcriptional repressor of the major vegetative catalase gene in Streptomyces
Pirins are iron-containing proteins conserved throughout evolution, which have been implicated in diverse cellular processes, mostly associated with s…
www.sciencedirect.com
September 6, 2025 at 7:03 PM
clintoak.bsky.social
We show that anemones absorb #lipid nanoparticles directly from seawater, stimulating their #metabolism. Details, and potential applications for #coral reef restoration and aquaculture, in our new preprint!

www.biorxiv.org/content/10.1...

#science #marinebiology #symbiosis #proteomics
Lipid nanoparticles are absorbed by the anemone Exaiptasia diaphana and stimulate lipid metabolism, including beta-oxidation and the TCA cycle.
October 7, 2025 at 1:07 AM