I've written a review on what I think is an extremely exciting direction in cryo-EM:
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
March 6, 2026 at 12:40 PM
I've written a review on what I think is an extremely exciting direction in cryo-EM:
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
She won me over with her phospholipid bilayer. She seduced me with her semipermeable membrane.
September 17, 2024 at 4:49 PM
She won me over with her phospholipid bilayer. She seduced me with her semipermeable membrane.
we don’t fully understand how anesthetics work, you know. GABAA-R target effects are fairly straightforward but there also seem to be some fascinating lipid bilayer-dependent mechanics at play and a whole lot of competing theories about…
Yes, yes, the gas *does* smell like bubblegum dear
Yes, yes, the gas *does* smell like bubblegum dear
September 24, 2026 at 6:52 PM
we don’t fully understand how anesthetics work, you know. GABAA-R target effects are fairly straightforward but there also seem to be some fascinating lipid bilayer-dependent mechanics at play and a whole lot of competing theories about…
Yes, yes, the gas *does* smell like bubblegum dear
Yes, yes, the gas *does* smell like bubblegum dear
Nature research paper: Observation of a superfluid-to-insulator transition of bilayer excitons
go.nature.com/4alOEkf
go.nature.com/4alOEkf
Observation of a superfluid-to-insulator transition of bilayer excitons - Nature
Transition of superfluid to insulator is observed in the layer-imbalanced regime of bilayer magnetoexcitons.
go.nature.com
February 2, 2026 at 9:42 AM
Nature research paper: Observation of a superfluid-to-insulator transition of bilayer excitons
go.nature.com/4alOEkf
go.nature.com/4alOEkf
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
May 6, 2025 at 9:01 AM
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
Nature research paper: Superconductivity in 5.0° twisted bilayer WSe2
https://go.nature.com/3PLNLGx
https://go.nature.com/3PLNLGx
Superconductivity in 5.0° twisted bilayer WSe2 - Nature
We report superconductivity, in a limited region of displacement field and density, in 5.0° twisted bilayer WSe2 with a maximum critical temperature of 426 mK, establishing that moiré flat-band superconductivity extends beyond graphene structures.
go.nature.com
January 22, 2025 at 8:14 PM
Nature research paper: Superconductivity in 5.0° twisted bilayer WSe2
https://go.nature.com/3PLNLGx
https://go.nature.com/3PLNLGx
In @justinditrani.bsky.social final postdoc paper (with contributions from many others) we show that forming/purifying vesicles (here from M. smegmatis) allows structure det'n of *endogenous* membrane proteins in their *native lipid bilayer*
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
February 19, 2025 at 9:13 PM
In @justinditrani.bsky.social final postdoc paper (with contributions from many others) we show that forming/purifying vesicles (here from M. smegmatis) allows structure det'n of *endogenous* membrane proteins in their *native lipid bilayer*
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
Cell membrane/phospholipid bilayer leather cuff, 2016.
Almost got my leather crafting spot reassembled :> I miss working with it! #sciart #ArtAdventCalendar
Almost got my leather crafting spot reassembled :> I miss working with it! #sciart #ArtAdventCalendar
December 5, 2024 at 7:14 PM
Cell membrane/phospholipid bilayer leather cuff, 2016.
Almost got my leather crafting spot reassembled :> I miss working with it! #sciart #ArtAdventCalendar
Almost got my leather crafting spot reassembled :> I miss working with it! #sciart #ArtAdventCalendar
The fluid mosaic model of an animal or plant cell describes cell membranes as both solid and permeable. It depicts the membrane as a flexible lipid bilayer with proteins embedded within it, like a crisscross pattern.
ㅤ
October 20, 2024 at 12:08 PM
The fluid mosaic model of an animal or plant cell describes cell membranes as both solid and permeable. It depicts the membrane as a flexible lipid bilayer with proteins embedded within it, like a crisscross pattern.
ㅤ
Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself.
doi.org/10.1038/s415... 1/5
doi.org/10.1038/s415... 1/5
August 17, 2026 at 11:11 PM
Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself.
doi.org/10.1038/s415... 1/5
doi.org/10.1038/s415... 1/5
Nature research paper: Twist-programmable superconductivity in spin–orbit-coupled bilayer graphene
https://go.nature.com/4m3F9Ki
https://go.nature.com/4m3F9Ki
Twist-programmable superconductivity in spin–orbit-coupled bilayer graphene - Nature
The superconductivity in Bernal bilayer graphene that emerges from the spin–orbit coupling induced by proximal tungsten diselenide can be tuned by modulating the twist angle between the two materials.
go.nature.com
May 12, 2025 at 2:35 PM
Nature research paper: Twist-programmable superconductivity in spin–orbit-coupled bilayer graphene
https://go.nature.com/4m3F9Ki
https://go.nature.com/4m3F9Ki
Keep Honking, I'm Evolving A Lipid Bilayer
January 6, 2026 at 10:09 PM
Keep Honking, I'm Evolving A Lipid Bilayer
Very thorough work that applies cryo-ET to measure bilayer thickness. Surprisingly, the missing wedge is not a big problem!
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
November 5, 2025 at 1:00 PM
Very thorough work that applies cryo-ET to measure bilayer thickness. Surprisingly, the missing wedge is not a big problem!
A new type of all-perovskite triple-junction solar cell achieves a high power conversion efficiency of 27.3% and demonstrates unprecedented operational stability. 🧪⚛️ physicsworld.com/a/bilayer-ap...
Bilayer approach ramps performance of all-perovskite triple-junction solar cells – Physics World
A novel graphene oxide bilayer pushes triple-junction perovskite solar cells to a milestone 27.3% efficiency with unprecedented operational longevity
physicsworld.com
September 9, 2026 at 2:21 PM
A new type of all-perovskite triple-junction solar cell achieves a high power conversion efficiency of 27.3% and demonstrates unprecedented operational stability. 🧪⚛️ physicsworld.com/a/bilayer-ap...
idea: big tent but the walls are a semipermeable membrane
nature abhors a vacuum but it fuckin loves a lipid bilayer
nature abhors a vacuum but it fuckin loves a lipid bilayer
May 5, 2026 at 1:53 AM
idea: big tent but the walls are a semipermeable membrane
nature abhors a vacuum but it fuckin loves a lipid bilayer
nature abhors a vacuum but it fuckin loves a lipid bilayer
Nature research paper: Bilayer nanographene reveals halide permeation through a benzene hole
https://go.nature.com/3Pz2Prb
https://go.nature.com/3Pz2Prb
Bilayer nanographene reveals halide permeation through a benzene hole - Nature
Halide permeation through a single benzene-sized defect in a molecular nanographene shows the permeability of fluoride, chloride and bromide, whereas iodide is impermeable.
go.nature.com
January 16, 2025 at 9:31 AM
Nature research paper: Bilayer nanographene reveals halide permeation through a benzene hole
https://go.nature.com/3Pz2Prb
https://go.nature.com/3Pz2Prb
#OEA_highlight In-situ and ex-situ twisted bilayer liquid crystal computing platform for reconfigurable image processing doi.org/10.29026/oea... by Prof. #Yougang_Ke #Linzhou_Zeng #Xinxing_Zhou @HNUofficial #reconfigurable #image #bilayer #liquid_crystal #mechanical #photonic #Spin_Hall_effect
December 25, 2025 at 8:59 AM
#OEA_highlight In-situ and ex-situ twisted bilayer liquid crystal computing platform for reconfigurable image processing doi.org/10.29026/oea... by Prof. #Yougang_Ke #Linzhou_Zeng #Xinxing_Zhou @HNUofficial #reconfigurable #image #bilayer #liquid_crystal #mechanical #photonic #Spin_Hall_effect
Nature research paper: Angle evolution of the superconducting phase diagram in twisted bilayer WSe2
go.nature.com/4doqB6d
go.nature.com/4doqB6d
Angle evolution of the superconducting phase diagram in twisted bilayer WSe2 - Nature
Superconductivity in twisted bilayer WSe2 evolves smoothly with twist angle and emerges near Fermi surface reconstruction, linking previously distinct phase diagrams and clarifying its correlated origin.
go.nature.com
April 6, 2026 at 12:21 PM
Nature research paper: Angle evolution of the superconducting phase diagram in twisted bilayer WSe2
go.nature.com/4doqB6d
go.nature.com/4doqB6d
Nature research paper: Quantum twisting microscopy of phonons in twisted bilayer graphene
https://go.nature.com/4ixtLng
https://go.nature.com/4ixtLng
Quantum twisting microscopy of phonons in twisted bilayer graphene - Nature
Generalization of a quantum twisting microscope to cryogenic temperatures in twisted bilayer graphene shows the ability to map phononic dispersions through inelastic momentum-conserving tunnelling and reveals an angle-dependent coupling between electrons and phonons.
go.nature.com
April 24, 2025 at 6:12 PM
Nature research paper: Quantum twisting microscopy of phonons in twisted bilayer graphene
https://go.nature.com/4ixtLng
https://go.nature.com/4ixtLng
We have lab stickers! I will absolutely abuse them
Thanks to @cterminiphd.bsky.social for the details of where to get them made!
#NewPI
Thanks to @cterminiphd.bsky.social for the details of where to get them made!
#NewPI
March 10, 2025 at 9:33 PM
We have lab stickers! I will absolutely abuse them
Thanks to @cterminiphd.bsky.social for the details of where to get them made!
#NewPI
Thanks to @cterminiphd.bsky.social for the details of where to get them made!
#NewPI
Out in @naturechemistry.bsky.social! Moiré 2D COF superlattices—synthesized straight from the monomers! 🤔2D polymer bilayers or bilayer 2D COFs? 🚀 Exciting collaborative work with @ZGaolei @yihanzhu @manuelmellelab.bsky.social @DeFeyterGroup and LohKP!
🔗 Read more: nature.com/articles/s41...
🔗 Read more: nature.com/articles/s41...
February 21, 2025 at 8:59 AM
Out in @naturechemistry.bsky.social! Moiré 2D COF superlattices—synthesized straight from the monomers! 🤔2D polymer bilayers or bilayer 2D COFs? 🚀 Exciting collaborative work with @ZGaolei @yihanzhu @manuelmellelab.bsky.social @DeFeyterGroup and LohKP!
🔗 Read more: nature.com/articles/s41...
🔗 Read more: nature.com/articles/s41...
Amazingly, this gave us a high-confidence transmembrane channel for both mouse and human NS3, with oleic acids forming a bilayer-like pattern.
Our group now call this the “fatty acid hack.”
The #alphafold predictions with and without fatty acids shown below 👇
Our group now call this the “fatty acid hack.”
The #alphafold predictions with and without fatty acids shown below 👇
June 18, 2025 at 11:47 AM
Amazingly, this gave us a high-confidence transmembrane channel for both mouse and human NS3, with oleic acids forming a bilayer-like pattern.
Our group now call this the “fatty acid hack.”
The #alphafold predictions with and without fatty acids shown below 👇
Our group now call this the “fatty acid hack.”
The #alphafold predictions with and without fatty acids shown below 👇