#bonetissueengineering
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drjzp.bsky.social
Leaving the office having just pressed the button on our next big grant application today! Keep everything crossed! 🤞🏻 🤞🏻 🤞🏻 #bonetissueengineering #bone #tissueengineering
February 21, 2025 at 6:51 PM
intjextremmanuf.bsky.social
Coiled PCL fibrous bundles fabricated using an alginate-based composite system & #3DPrinting, demonstrate enhanced mechanotransduction & upregulation of #Osteogenic-genes in hASCs, highlighting its potential in #BoneTissueEngineering.

#IJEM #OpenAccess: doi.org/10.1088/2631...
December 2, 2025 at 7:50 AM
genesndiseases.bsky.social
LGR4 enhances #BMP9-induced #osteogenesis in #MesenchymalStemCells via mTORC1/Stat3 signaling, promoting bone formation while its inhibition shifts differentiation toward #adipogenesis, highlighting LGR4 as a key target in #BoneTissueEngineering.

#OpenAccess: doi.org/10.1016/j.ge...
BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells
April 9, 2026 at 3:00 PM
erfan-salahinejad.bsky.social
🧪 Part of our research journey with students and collaborators on Mg–Ca Silicate Microspheres as Bone Defect Fillers & Drug Delivery Systems.

🌐 Open-access papers:

wp.kntu.ac.ir/salahinejad/...

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#DrugDelivery #Biomaterials #BoneTissueEngineering #ControlledRelease #Bioceramics
Graphical abstract of Mg–Ca silicate microspheres for bone-defect filling and antibiotic delivery. Bredigite, akermanite and diopside microspheres are loaded with vancomycin and PLGA-coated to reduce burst release, balance diffusion and bioresorption, and improve cell compatibility. Erfan Salahinejad
August 23, 2026 at 5:22 AM
erfan-salahinejad.bsky.social
🦴 Part of our research journey with students and collaborators on Bone Tissue Engineering Using Sacrificial Foam Replica-Processed Scaffolds.

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#BoneTissueEngineering #FoamReplica #Biomaterials #DrugDelivery #Bioceramics
Infographic illustrating the evolution of foam replica-processed bone tissue engineering scaffolds. On the left, a simplified workflow shows polyurethane foam templating, sol–gel slurry infiltration, burnout and sintering, resulting in a highly porous Mg–Ca silicate scaffold. At the center, a large three-dimensional porous ceramic scaffold is highlighted with the descriptors "Stronger," "Smarter," and "Bioactive," emphasizing its application in bone regeneration. On the right, four key enhancement strategies are summarized: PLGA coating for improved mechanical strength, sustained vancomycin delivery and drug release control, strontium/fluoride incorporation for enhanced bioactivity and biodegradation, and improved cytocompatibility with increased cell viability and biomineralization- Erfan Salahinejad
July 31, 2026 at 12:49 PM
erfan-salahinejad.bsky.social
Part of our research journey on freeze-dried scaffolds for bone tissue engineering to improve vascularization and osteogenesis

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#BoneTissueEngineering #Biomaterials #Scaffolds #RegenerativeMedicine #BoneRegeneration #BioactiveGlass #FreezeDrying #TissueEngineering
Infographic illustrating three freeze-dried scaffold strategies for bone tissue engineering. The left panel shows a highly porous scaffold composed of silk fibroin, decellularized extracellular matrix (ECM), and strontium-doped mesoporous bioactive glass, highlighting enhanced porosity, mechanical strength, stem cell proliferation, and osteogenesis. The center panel presents a gelatin scaffold reinforced with copper-doped calcium–magnesium silicates, emphasizing improved vascularization through endothelial cell adhesion, capillary network formation, and angiogenesis. The right panel depicts a chitosan/alginate scaffold containing mesoporous silica nanoparticles, demonstrating increased mechanical strength, controlled degradation, and enhanced biomineralization. All three approaches converge toward improved cell viability, osteogenic differentiation, vascularization, and bone regeneration, illustrating complementary biomaterial strategies for advanced bone tissue engineering. - Erfan Salahinejad
July 16, 2026 at 3:16 PM
erfan-salahinejad.bsky.social
🧪 Part of our research journey on 3D-printed chitosan scaffolds for bone tissue engineering

A thread on our work in personalized bone regeneration, bioactive scaffolds, and antibacterial therapy.

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#BoneTissueEngineering #3DPrinting #Biomaterials #Chitosan #RegenerativeMedicine
Graphical abstract illustrating the overall scope of our research on 3D-printed chitosan scaffolds for bone tissue engineering. A central porous scaffold symbolizes customizable, extrusion-based biomaterial fabrication, surrounded by visual elements highlighting bioactivity, biocompatibility, interconnected porosity, cell adhesion, vascularized bone regeneration, controlled local drug delivery, and antibacterial functionality when required. The illustration emphasizes personalized scaffold design for craniofacial reconstruction, bone defect repair, and osteomyelitis treatment, integrating advanced biomaterials and 3D printing into a unified strategy for regenerative medicine. - Erfan Salahinejad
July 7, 2026 at 2:20 PM
intjextremmanuf.bsky.social
Inspired by LEGO® bricks, this #IJEM study developed innovative modular scaffolds, based on machine vision for rapid & intelligent assembly according to #BoneDefects, highlighting their potential in #BoneTissueEngineering.

#OpenAccess: doi.org/10.1088/2631...
December 3, 2025 at 12:30 AM
genesndiseases.bsky.social
#SIRT5 boosts #BMP9‑induced #osteogenesis by stabilizing #HIF1α via reduced acetylation/malonylation, elevating osteogenic markers and enhancing #BoneRegeneration, offering a novel strategy for improved #BoneTissueEngineering outcomes.
#OpenAccess: doi.org/10.1016/j.ge...
April 6, 2026 at 6:28 PM
erfan-salahinejad.bsky.social
🧪 Research journey on Bioactive Surface Engineering & Osseointegration of Metallic Biomaterials

Studies on Ca–Mg silicate-based coatings, chitosan nanocomposites, and bone-like mineralization.

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#Biomaterials #Osseointegration #BioactiveCoatings #Chitosan #BoneTissueEngineering
Surface modification of metallic biomaterials using Ca–Mg silicate-based bioceramic coatings, chitosan-based nanocomposites, and mechanistic investigation of bone-like mineralization- Erfan Salahinejad
June 15, 2026 at 8:34 PM