NUB1 mediates skeletal muscle atrophy in lung cancer cachexia. Upregulated NUB1 recruits IκBα and S5a, triggering IκBα degradation and NF‑κB nuclear translocation. Activated NF‑κB elevates Atrogin1 a...

In cancer cachexia, patients continue to lose weight, muscle and fat even when they eat. A KAIST research team has developed a therapeutic candidate that blocks a signal responsible for appetite suppression, weight loss and excessive energy expenditure.

In cancer cachexia, patients continue to lose weight, muscle and fat even when they eat. A KAIST research team has developed a therapeutic candidate that blocks a signal responsible for appetite suppression, weight loss and excessive energy expenditure.

Experts in **sleep medicine** emphasize that adequate rest should be treated as a crucial health measure, alongside proper nutrition and exercise, warning that performance and health inevitably suffer when rest is restricted. In oncology, researchers are investigating **cancer-induced cachexia** , a severe muscle-wasting condition driven by tumor-released inflammatory signals that significantly contributes to mortality rates, by targeting underlying molecular pathways rather than just managing symptoms. Additionally, recent agricultural research demonstrates that **elevated carbon dioxide levels** significantly alter the protein composition of wheat, impacting baking quality and potential digestive tolerance, which highlights the need for crop breeding strategies to focus on nutritional and qualitative traits rather than mere harvest volume. English Edition MINQs weekly 43 26 0:00 /1220.115737 1×

Tumors often reprogram host metabolism in distant organs to fuel their growth, but the underlying mechanisms remain unclear. Here, the authors show that in Drosophila, gut tumors secrete the PDGF/VEGF-like factor Pvf1, which activates lipid production in the hepatocyte-like oenocytes to support tracheal growth around the tumor, promoting tumor progression and cachexia-like wasting.

AVEO Oncology announces an accepted abstract for presentation at ESMO 2026, demonstrating promising results of rilogrotug for cancer cachexia.