Enzymes that can quickly and efficiently fix carbon

The conversion of CO2 by enzymes such as carbonic anhydrase or carboxylases plays a crucial role in many biological processes. However, in situ methods following the microscopic details of CO2 convers...

Les énoyl-CoA carboxylases/réductases sont des enzymes capables de fixer rapidement et efficacement le carbone.

Acetyl-coenzyme A carboxylases (ACCs) are pivotal in fatty acid metabolism, converting acetyl-CoA to malonyl-CoA. While ACCs in humans, plants, and microbes have been extensively studied, insect ACCs,...

Through the identification of Arabidopsis mutants with increased aluminum resistance, an unexpected approach to deconstruct plant Phosphoenolpyruvate carboxylases has been identified giving the means...

炭素固定を高速で効率的に行う酵素

Biotin, a vitamin whose main role is as a coenzyme for carboxylases, accumulates at unusually large amounts within cells of the carotid body (CB). In biotin‐deficient rats biotin rapidly disappears fr...

The TOFA molecule, which targets fatty acid synthesis enzymes and nuclear receptors, reduced body weight in mice by approximately 18% over four weeks. The weight loss occurred in adipose tissue while muscle mass was preserved. These results were obtained exclusively in animal experiments; additional preclinical and clinical trials are required before human use. Mechanism of Action TOFA inhibits acetyl-CoA carboxylases ACC1 and ACC2, enzymes involved in the synthesis of fatty acids. Simultaneously, the molecule partially activates PPARα and PPARδ nuclear receptors, which regulate lipid and energy metabolism. Researchers suggest this combined action limits the formation of new lipids and stimulates the use of fat stores for energy. Unlike GLP-1 receptor agonists, which reduce food intake by suppressing appetite, TOFA works by increasing energy expenditure. In metabolic chambers, mice receiving the compound showed energy expenditure approximately 18% higher than the control group, while continuing to consume the same amount of food as before treatment.

Acetone carboxylases (ACs) catalyze the metal- and ATP-dependent conversion of acetone and bicarbonate to form acetoacetate. Interestingly, two homologous ACs that have been biochemically characterized have been reported to have different metal…

Human acetyl-CoA carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-lim

Biotin, a vitamin whose main role is as a coenzyme for carboxylases, accumulates at unusually large amounts within cells of the carotid body (CB). In biotin‐deficient rats biotin rapidly disappears fr...

Biotin, a vitamin whose main role is as a coenzyme for carboxylases, accumulates at unusually large amounts within cells of the carotid body (CB). In biotin‐deficient rats biotin rapidly disappears fr...

Biotin, a vitamin whose main role is as a coenzyme for carboxylases, accumulates at unusually large amounts within cells of the carotid body (CB). In biotin‐deficient rats biotin rapidly disappears fr...