THIS is HUGE! Researchers at Mie University in Japan have successfully used CRISPR Cas9 gene editing to remove the extra chromosome 21 responsible for Down syndrome from human cells for the first time. The team is led by Dr. Ryotaro Hashizume. Published in PNAS Nexus
June 18, 2026 at 11:08 AM
THIS is HUGE! Researchers at Mie University in Japan have successfully used CRISPR Cas9 gene editing to remove the extra chromosome 21 responsible for Down syndrome from human cells for the first time. The team is led by Dr. Ryotaro Hashizume. Published in PNAS Nexus
1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵
🔗 www.nature.com/articles/s41...
#CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
🔗 www.nature.com/articles/s41...
#CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity - Nature
Cas9 structures explain topology sensing and off-target activation.
www.nature.com
March 25, 2026 at 6:09 PM
1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵
🔗 www.nature.com/articles/s41...
#CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
🔗 www.nature.com/articles/s41...
#CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
A new report from Nature , published on September 28, takes stock of the field of genetic editing a decade after CRISPR-Cas9 revolutionized biology.
Beyond CRISPR: The New Generation of Genome Editors - Sinaptica
A new report from Nature, published on September 28, takes stock of the field of genetic editing a decade after CRISPR-Cas9 revolutionized biology. Journalist S
sinapti.ca
September 29, 2026 at 1:13 AM
A new report from Nature , published on September 28, takes stock of the field of genetic editing a decade after CRISPR-Cas9 revolutionized biology.
It makes me so unbelievably sad how much progress on mRNA vaccines is going to be delayed.
Arguably the most impactful applied biochemistry breakthrough since CRISPR-Cas9 and the full benefits are going to end up unnecessarily delayed for a decade
Arguably the most impactful applied biochemistry breakthrough since CRISPR-Cas9 and the full benefits are going to end up unnecessarily delayed for a decade
June 3, 2025 at 3:30 PM
It makes me so unbelievably sad how much progress on mRNA vaccines is going to be delayed.
Arguably the most impactful applied biochemistry breakthrough since CRISPR-Cas9 and the full benefits are going to end up unnecessarily delayed for a decade
Arguably the most impactful applied biochemistry breakthrough since CRISPR-Cas9 and the full benefits are going to end up unnecessarily delayed for a decade
The first all-female team to share a Nobel Prize in science: biochemists Jennifer Doudna & Emmanuelle Charpentier.
They won the 2020 #Nobel Prize in #Chemistry "for the development of a method for genome editing (CRISPR-Cas9)." Jennifer Doudna was born #OTD in 1964.
#WomenInSTEM
They won the 2020 #Nobel Prize in #Chemistry "for the development of a method for genome editing (CRISPR-Cas9)." Jennifer Doudna was born #OTD in 1964.
#WomenInSTEM
February 19, 2026 at 4:12 PM
The first all-female team to share a Nobel Prize in science: biochemists Jennifer Doudna & Emmanuelle Charpentier.
They won the 2020 #Nobel Prize in #Chemistry "for the development of a method for genome editing (CRISPR-Cas9)." Jennifer Doudna was born #OTD in 1964.
#WomenInSTEM
They won the 2020 #Nobel Prize in #Chemistry "for the development of a method for genome editing (CRISPR-Cas9)." Jennifer Doudna was born #OTD in 1964.
#WomenInSTEM
CRISPR/Cas9, a powerful gene-editing technology has been successfully used to treat sickle cell disease, a painful life-threatening inherited blood disorder | Dr Alan Porter
@bylines.scot
@bylines.scot
A major breakthrough in gene therapy for the treatment of sickle cell disease
CRISPR/Cas9, a powerful gene-editing technology has been successfully used to treat sickle cell disease, a painful life-threatening inherited blood disorder
bylines.scot
February 26, 2025 at 7:07 AM
CRISPR/Cas9, a powerful gene-editing technology has been successfully used to treat sickle cell disease, a painful life-threatening inherited blood disorder | Dr Alan Porter
@bylines.scot
@bylines.scot
Someone got Cas9-Turbo to work. It's like basically Y1H but with proteomics. It however requires transgenic plant expressing Cas9-Turbo and gRNAs, which is still cumbersome for many plants that are not Arabidopsis. #PlantSciences
New Brief Communication: "A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins" rdcu.be/eZLUP
CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .
CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .
January 19, 2026 at 6:47 PM
Someone got Cas9-Turbo to work. It's like basically Y1H but with proteomics. It however requires transgenic plant expressing Cas9-Turbo and gRNAs, which is still cumbersome for many plants that are not Arabidopsis. #PlantSciences
𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐚𝐬𝟗 is a process in which clustered regularly interspaced short palindromic repeats (CRISPR) generate guide RNAs, which are used together with a DNA-cutting enzyme (Cas9) by the bacterium to defend against viral infection. Full definition: nej.md/3Rc1MQ0
#ScienceSky
#ScienceSky
June 13, 2025 at 8:09 PM
𝐂𝐑𝐈𝐒𝐏𝐑-𝐂𝐚𝐬𝟗 is a process in which clustered regularly interspaced short palindromic repeats (CRISPR) generate guide RNAs, which are used together with a DNA-cutting enzyme (Cas9) by the bacterium to defend against viral infection. Full definition: nej.md/3Rc1MQ0
#ScienceSky
#ScienceSky
CRISPR genome editing clicks for amyloid cardiomyopathy.
nejm.org/doi/full/10.... A Phase 1 study with marked reduction of serum TTR
nejm.org/doi/full/10.... A Phase 1 study with marked reduction of serum TTR
CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy | NEJM
Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, often fatal disease. Nexiguran ziclumeran (nex-z) is an investigational therapy based on CRISPR-Cas9 (clustered regularly i...
nejm.org
November 16, 2024 at 4:01 PM
CRISPR genome editing clicks for amyloid cardiomyopathy.
nejm.org/doi/full/10.... A Phase 1 study with marked reduction of serum TTR
nejm.org/doi/full/10.... A Phase 1 study with marked reduction of serum TTR
High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
October 4, 2025 at 9:10 PM
High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
#CRISPR #Drosophila
www.biorxiv.org/content/10.1...
🏆 Biochemist Martin Jinek is the winner of the Swiss Science Prize #MarcelBenoist 2026, considered the Swiss #Nobel Prize.
He contributed to the development of molecular scissors, namely CRISPR-Cas9 technology.
Read more ➡️ sohub.io/3hs4
He contributed to the development of molecular scissors, namely CRISPR-Cas9 technology.
Read more ➡️ sohub.io/3hs4
September 22, 2026 at 8:02 AM
🏆 Biochemist Martin Jinek is the winner of the Swiss Science Prize #MarcelBenoist 2026, considered the Swiss #Nobel Prize.
He contributed to the development of molecular scissors, namely CRISPR-Cas9 technology.
Read more ➡️ sohub.io/3hs4
He contributed to the development of molecular scissors, namely CRISPR-Cas9 technology.
Read more ➡️ sohub.io/3hs4
Nature research paper: Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity
go.nature.com/4t39bk8
go.nature.com/4t39bk8
Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity - Nature
Cas9 structures explain topology sensing and off-target activation.
go.nature.com
March 30, 2026 at 2:16 PM
Nature research paper: Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity
go.nature.com/4t39bk8
go.nature.com/4t39bk8
Our last pre-print of 2024! We created a simple, temporally-controlled CRISPR/Cas9 system that doesn’t compromise between background and induced editing. As best we can tell, this is the closest thing to a "worry free" inducible Cas9 approach out there. See thread.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation
CRISPR/Cas9 technologies provide unique capabilities for modeling disease and understanding gene-to-phenotype connections. In cultured cells, chemical-mediated control of Cas9 activity can limit off-t...
www.biorxiv.org
December 28, 2024 at 4:55 PM
Our last pre-print of 2024! We created a simple, temporally-controlled CRISPR/Cas9 system that doesn’t compromise between background and induced editing. As best we can tell, this is the closest thing to a "worry free" inducible Cas9 approach out there. See thread.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CRISPR/Cas9, a powerful gene-editing technology has been successfully used to treat sickle cell disease, a painful life-threatening blood disorder | Dr Alan Porter
A major breakthrough in gene therapy for the treatment of sickle cell disease
CRISPR/Cas9, a powerful gene-editing technology has been successfully used to treat sickle cell disease, a painful life-threatening inherited blood disorder
bylines.scot
February 26, 2025 at 7:07 AM
CRISPR/Cas9, a powerful gene-editing technology has been successfully used to treat sickle cell disease, a painful life-threatening blood disorder | Dr Alan Porter
Very excited to share the first story from my postdoc where we uncover the structural basis for slow Cas9 turnover!
We use kinetics-guided cryo-EM to capture 25 conformational states of SpCas9 from a single dataset - including the first look at Cas9 releasing product.
biorxiv.org/content/10.1...
We use kinetics-guided cryo-EM to capture 25 conformational states of SpCas9 from a single dataset - including the first look at Cas9 releasing product.
biorxiv.org/content/10.1...
November 28, 2024 at 12:32 PM
Very excited to share the first story from my postdoc where we uncover the structural basis for slow Cas9 turnover!
We use kinetics-guided cryo-EM to capture 25 conformational states of SpCas9 from a single dataset - including the first look at Cas9 releasing product.
biorxiv.org/content/10.1...
We use kinetics-guided cryo-EM to capture 25 conformational states of SpCas9 from a single dataset - including the first look at Cas9 releasing product.
biorxiv.org/content/10.1...
🎉 Congratulations to Jennifer Doudna! The Nobel Laureate has just received the @acs.org‘s Priestley Medal for her incredible work on CRISPR-Cas9 🧬 and contributions to unlocking the power of RNA. 🧪
@biosci.lbl.gov
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
@biosci.lbl.gov
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
Jennifer Doudna Wins American Chemical Society’s Priestley Award
The Nobel Laureate has received the American Chemical Society’s highest prize for her breakthrough work on CRISPR-Cas9
newscenter.lbl.gov
August 5, 2025 at 8:49 PM
🎉 Congratulations to Jennifer Doudna! The Nobel Laureate has just received the @acs.org‘s Priestley Medal for her incredible work on CRISPR-Cas9 🧬 and contributions to unlocking the power of RNA. 🧪
@biosci.lbl.gov
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
@biosci.lbl.gov
@innovativegenomics.bsky.social
@ucberkeleyofficial.bsky.social
Settling into summer with a deep dive into the conformational landscape of a multi-turnover Cas9. Happy to see my work with @davidwtaylorjr.bsky.social out in full form. Sneak peek of one (of many) structures below. Link to the full story here: rdcu.be/euifk
Visualization of a multi-turnover Cas9 after product release
Nature Communications - Streptococcus pyogenes Cas9 is perhaps the most widely used CRISPR-Cas enzyme. Here, cryo-EM structures provide insight into the conformational landscape of Cas9 under...
rdcu.be
July 2, 2025 at 11:30 AM
Settling into summer with a deep dive into the conformational landscape of a multi-turnover Cas9. Happy to see my work with @davidwtaylorjr.bsky.social out in full form. Sneak peek of one (of many) structures below. Link to the full story here: rdcu.be/euifk
Weyland-Yutani crispr cas9 kitns with acidic immunity used to deal with chest bursters
July 30, 2025 at 5:26 PM
Weyland-Yutani crispr cas9 kitns with acidic immunity used to deal with chest bursters
Il y a 62 ans, le 19 février 1964, naquit Jennifer Doudna, biochimiste et de biologiste moléculaire. Elle sera co-lauréate avec Emmanuelle Charpentier du prix Nobel de chimie 2020 « pour avoir mis au point la technique d'édition génomique CRISPR-Cas9 » #LaPetiteInfoDuJour
February 19, 2026 at 11:51 AM
Il y a 62 ans, le 19 février 1964, naquit Jennifer Doudna, biochimiste et de biologiste moléculaire. Elle sera co-lauréate avec Emmanuelle Charpentier du prix Nobel de chimie 2020 « pour avoir mis au point la technique d'édition génomique CRISPR-Cas9 » #LaPetiteInfoDuJour
Researchers have discovered a variant of Cas9 that selectively cuts DNA based on its methylation state: cen.acs.org/biological-c...
#chemsky 🧪
#chemsky 🧪
April 18, 2026 at 6:18 PM
Researchers have discovered a variant of Cas9 that selectively cuts DNA based on its methylation state: cen.acs.org/biological-c...
#chemsky 🧪
#chemsky 🧪
In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning - Nature
Nature - Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning
www.nature.com
April 22, 2025 at 8:57 PM
In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phage-encoded single-guide RNAs subvert CRISPR-Cas9 immunity https://www.biorxiv.org/content/10.64898/2026.06.01.729453v1
June 2, 2026 at 7:16 PM
Phage-encoded single-guide RNAs subvert CRISPR-Cas9 immunity https://www.biorxiv.org/content/10.64898/2026.06.01.729453v1
Now online at Molecular Cell! What makes SpyCas9 such an efficient editor? Read more at: www.cell.com/molecular-ce...
Congrats @honglue.bsky.social, Noor Al-Sayyad, and @kevinwasko.bsky.social!
Congrats @honglue.bsky.social, Noor Al-Sayyad, and @kevinwasko.bsky.social!
April 23, 2025 at 9:49 PM
Now online at Molecular Cell! What makes SpyCas9 such an efficient editor? Read more at: www.cell.com/molecular-ce...
Congrats @honglue.bsky.social, Noor Al-Sayyad, and @kevinwasko.bsky.social!
Congrats @honglue.bsky.social, Noor Al-Sayyad, and @kevinwasko.bsky.social!
日本分子生物学会が発行する学会誌Genes to Cellsの表紙コレクション
細胞分裂で分配される染色体ネコちゃん達
DNAをCas9で切る三代目 大谷鬼次（紋がCas9の九だ！）
DNA二重らせん？
アルミニウムイオンによる花の色変化
細胞分裂で分配される染色体ネコちゃん達
DNAをCas9で切る三代目 大谷鬼次（紋がCas9の九だ！）
DNA二重らせん？
アルミニウムイオンによる花の色変化
Just discovered the wonderful covers of 'Genes to Cells', the journal of the Molecular Biology Society of Japan @mbsj-official.bsky.social – absolutely beautiful!
here some examples inspired by mitosis, CRISPR, the DNA helix, and plant pigments
here some examples inspired by mitosis, CRISPR, the DNA helix, and plant pigments
February 5, 2026 at 3:06 PM
日本分子生物学会が発行する学会誌Genes to Cellsの表紙コレクション
細胞分裂で分配される染色体ネコちゃん達
DNAをCas9で切る三代目 大谷鬼次（紋がCas9の九だ！）
DNA二重らせん？
アルミニウムイオンによる花の色変化
細胞分裂で分配される染色体ネコちゃん達
DNAをCas9で切る三代目 大谷鬼次（紋がCas9の九だ！）
DNA二重らせん？
アルミニウムイオンによる花の色変化