CCR5 mutation bone marrow transplant?
*reads article*
yep CCR5 mutation transplant. Amazing stuff.
*reads article*
yep CCR5 mutation transplant. Amazing stuff.
December 11, 2024 at 2:52 AM
CCR5 mutation bone marrow transplant?
*reads article*
yep CCR5 mutation transplant. Amazing stuff.
*reads article*
yep CCR5 mutation transplant. Amazing stuff.
On this #WorldAIDSday @cgaebler.bsky.social, Olaf Penack & teams at #CharitéBerlin report the #SecondBerlinPatient cured of #HIV after heterozygous CCR5Δ32 HSCT. The study opens exciting perspectives for immune-based #HIVCure strategies for longterm ART-free viral control and ultimately cure.
Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation - Nature
Nature - Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation
www.nature.com
December 1, 2025 at 9:48 PM
On this #WorldAIDSday @cgaebler.bsky.social, Olaf Penack & teams at #CharitéBerlin report the #SecondBerlinPatient cured of #HIV after heterozygous CCR5Δ32 HSCT. The study opens exciting perspectives for immune-based #HIVCure strategies for longterm ART-free viral control and ultimately cure.
brilliant news! 7th person cured of HIV via bone marrow transplant- previously we thought you needed to lose both copies of the CCR5 gene (HIV uses CCR5 to enter cells) and donors with that mutation v rare. This cure achieved with the less rare case of 1 functional copy of CCR5! 🧪
A 7th person with HIV is probably cured after stem cell transplant for leukemia, scientists say
A man in Germany has no detectable HIV in his body after he was treated in 2015. Only six other cases have achieved the milestone since the AIDS epidemic began.
www.nbcnews.com
July 24, 2024 at 4:40 PM
brilliant news! 7th person cured of HIV via bone marrow transplant- previously we thought you needed to lose both copies of the CCR5 gene (HIV uses CCR5 to enter cells) and donors with that mutation v rare. This cure achieved with the less rare case of 1 functional copy of CCR5! 🧪
Eine neue Studie in der Fachzeitschrift „Nature“ mit RKI-Beteiligung zeigt: Ein Patient bleibt nach einer heterozygoten CCR5-Δ32-Stammzelltransplantation in HIV-Remission, ohne antiretrovirale Therapie.
December 1, 2025 at 4:01 PM
Eine neue Studie in der Fachzeitschrift „Nature“ mit RKI-Beteiligung zeigt: Ein Patient bleibt nach einer heterozygoten CCR5-Δ32-Stammzelltransplantation in HIV-Remission, ohne antiretrovirale Therapie.
Researchers in #ScienceTranslationalMedicine leverage adeno-associated vectors to deliver the CCR5-blocking HIV drug #leronlimab and show that a single dose elicits leronlimab expression and can partially suppress SHIV in infected macaques for as long as one year. https://scim.ag/493ivwQ
Adeno-associated virus gene therapy–mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques
A single dose of an AAV vector encoding the CCR5-blocking antibody leronlimab drives suppression of viremia in SHIV-infected macaques.
scim.ag
May 4, 2026 at 6:00 PM
Researchers in #ScienceTranslationalMedicine leverage adeno-associated vectors to deliver the CCR5-blocking HIV drug #leronlimab and show that a single dose elicits leronlimab expression and can partially suppress SHIV in infected macaques for as long as one year. https://scim.ag/493ivwQ
Our paper on the second Berlin patient came out in Nature today and I’m really happy we can share this story on World AIDS Day. I want to thank everyone on the team and all co-authors for their work over the years.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation - Nature
Nature - Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation
www.nature.com
December 1, 2025 at 10:40 PM
Our paper on the second Berlin patient came out in Nature today and I’m really happy we can share this story on World AIDS Day. I want to thank everyone on the team and all co-authors for their work over the years.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Astrocyte-derived CCL5 mediates brain infiltration of CCR5+ neutrophils that drives depression progression
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
May 21, 2025 at 8:50 PM
Astrocyte-derived CCL5 mediates brain infiltration of CCR5+ neutrophils that drives depression progression
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The IRF8-CCL8-CCR5 axis as an epigenetically potentiated nexus of innate and adaptive antitumor immunity @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 27, 2026 at 7:50 PM
The IRF8-CCL8-CCR5 axis as an epigenetically potentiated nexus of innate and adaptive antitumor immunity @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
"All four of these patients had undergone stem cell transplants for their blood cancer treatment. Their donors also had the same HIV-resistant mutation that deletes a protein called CCR5, which HIV normally uses to enter the cell."
5th person to be cured of HIV
“Today, researchers announced the Dusseldorf patient still has no detectable virus in his body, even after stopping his HIV medication four years ago.”
“Today, researchers announced the Dusseldorf patient still has no detectable virus in his body, even after stopping his HIV medication four years ago.”
5th person confirmed to be cured of HIV
Researchers are announcing that a 53-year-old man in Germany has been cured of HIV.
abcnews.go.com
December 11, 2024 at 12:41 PM
"All four of these patients had undergone stem cell transplants for their blood cancer treatment. Their donors also had the same HIV-resistant mutation that deletes a protein called CCR5, which HIV normally uses to enter the cell."
CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of women
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
September 27, 2026 at 5:34 PM
CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of women
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Geneticists have traced back the CCR5-delta32 allele to one person who lived 9,000 years ago near the Black Sea. 🏺🧪
Viking DNA helps reveal when HIV-fighting gene mutation emerged: 9,000 years ago near the Black Sea
A study of more than 3,000 genomes has traced a gene mutation that confers HIV resistance to a person who lived near the Black Sea around 7000 B.C.
www.livescience.com
May 12, 2025 at 10:11 PM
Geneticists have traced back the CCR5-delta32 allele to one person who lived 9,000 years ago near the Black Sea. 🏺🧪
Golpe de sorte? Paciente tem remissão de HIV após transplante de medula; entenda
www.diariodocentrodomundo.com.br/essencial/go...
www.diariodocentrodomundo.com.br/essencial/go...
Golpe de sorte? Paciente tem remissão de HIV após transplante de medula; entenda
Paciente tem remissão de HIV após transplante de medula com mutação CCR5; caso raro foi descrito em estudo científico.
www.diariodocentrodomundo.com.br
April 14, 2026 at 10:35 AM
Golpe de sorte? Paciente tem remissão de HIV após transplante de medula; entenda
www.diariodocentrodomundo.com.br/essencial/go...
www.diariodocentrodomundo.com.br/essencial/go...
Investigation of peripheral blood of rheumatoid arthritis patients reinforces the role of SLAMF4 in shaping cytotoxic response of CD4+ T cells and the effect of SLAM-associated protein on cytotoxic properties of F4+ effector memory T cells
In Arthritis & Rheumatology
doi.org/10.1002/art....
🧪
In Arthritis & Rheumatology
doi.org/10.1002/art....
🧪
![Cytotoxic and Th1 related transcripts are enriched in SLAMF4+ CCR5+ Tem. (A-F) RNA-sequencing experiments were performed on sorted PB F4+ CCR5+ and F4- CCR5+ Tem from RA patients (n=4). (A) Enriched functions and pathways of the 100 most significantly up-regulated genes in F4+ CCR5+ vs F4- CCR5+ Tem. The network of pathways was created using the ClueGo and CluePedia plugins in Cytoscape. (B) Pie chart showing the most significant terms. (C) Histogram showing the up-regulated terms in F4+ CCR5+ vs F4- CCR5+ Tem. (D) Heatmap showing the 274 up-regulated (red) and 530 down-regulated (blue) DEGs in SLAMF4+ CCR5+ Tem vs their SLAMF4- counterparts. The list of genes in the box to the left of the heatmap highlighted the presence of genes known to be over-expressed in CD4+ CTLs. [cropped figure]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:g5fr5vggcyl7dq3ub7zmdwrz/bafkreigpk6hzspsqox7bhg425kvefvmorpuoqzuictz3no2mkpuuox5auy)
February 6, 2025 at 9:09 PM
Investigation of peripheral blood of rheumatoid arthritis patients reinforces the role of SLAMF4 in shaping cytotoxic response of CD4+ T cells and the effect of SLAM-associated protein on cytotoxic properties of F4+ effector memory T cells
In Arthritis & Rheumatology
doi.org/10.1002/art....
🧪
In Arthritis & Rheumatology
doi.org/10.1002/art....
🧪
Hace unos meses se confirmó que un hombre alemán de 60 es el séptimo en el mundo en “curarse” del virus VIH tras recibir un trasplante de células madre que llevan una mutación en el gen que codifica al receptor CCR5. www.nature.com/articles/d41...
November 17, 2024 at 11:50 AM
Hace unos meses se confirmó que un hombre alemán de 60 es el séptimo en el mundo en “curarse” del virus VIH tras recibir un trasplante de células madre que llevan una mutación en el gen que codifica al receptor CCR5. www.nature.com/articles/d41...
Dies verdeutlicht, dass neben der CCR5-Δ32-Mutation auch weitere Faktoren, wie eine effektive Reduktion des HIV-Reservoirs, zu einer anhaltenden HIV-Remission beitragen können.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
December 1, 2025 at 4:01 PM
Dies verdeutlicht, dass neben der CCR5-Δ32-Mutation auch weitere Faktoren, wie eine effektive Reduktion des HIV-Reservoirs, zu einer anhaltenden HIV-Remission beitragen können.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Charité Berlin researchers report HIV remission lasting over 6 years in a man who received a stem cell transplant from a donor with only one copy of the CCR5Δ32 mutation.
This suggests full CCR5 resistance is not essential for long-term HIV cure.
www.nature.com/articles/s41...
This suggests full CCR5 resistance is not essential for long-term HIV cure.
www.nature.com/articles/s41...
Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation - Nature
Nature - Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation
www.nature.com
December 1, 2025 at 6:31 PM
Charité Berlin researchers report HIV remission lasting over 6 years in a man who received a stem cell transplant from a donor with only one copy of the CCR5Δ32 mutation.
This suggests full CCR5 resistance is not essential for long-term HIV cure.
www.nature.com/articles/s41...
This suggests full CCR5 resistance is not essential for long-term HIV cure.
www.nature.com/articles/s41...
Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
August 27, 2026 at 1:04 AM
Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
A new HIV cure case has just been reported. A patient in Oslo has achieved long-term HIV remission after a stem cell transplant from a sibling donor with a rare genetic mutation (CCR5Δ32/Δ32).
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor - Nature Microbiology
This case study reports human immunodeficiency virus remission without antiretroviral treatment in an individual who received an allogeneic haematopoietic stem cell transplantation from a sibling dono...
www.nature.com
April 16, 2026 at 3:48 PM
A new HIV cure case has just been reported. A patient in Oslo has achieved long-term HIV remission after a stem cell transplant from a sibling donor with a rare genetic mutation (CCR5Δ32/Δ32).
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
CCR5-targeted allogeneic CD19-CAR γδ T cells for HIV-associated B cell-malignancy immunotherapy
www.nature.com/articles/s41...
@natbiomedeng.nature.com
www.nature.com/articles/s41...
@natbiomedeng.nature.com
CCR5-targeted allogeneic gamma–delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy - Nature Biomedical Engineering
CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.
www.nature.com
October 21, 2025 at 9:10 PM
CCR5-targeted allogeneic CD19-CAR γδ T cells for HIV-associated B cell-malignancy immunotherapy
www.nature.com/articles/s41...
@natbiomedeng.nature.com
www.nature.com/articles/s41...
@natbiomedeng.nature.com
"Building a CRISPR Medicine: Core Principles and Real-World Case Studies" UC Berkeley MCB290, S2025, wk1:
Building a Gene-Edited CAR-T Therapeutic.
This is the oldest + best-established clinical gene editing modality: 2009 Sangamo trials in GBM (35100373) + HIV. [1/5]
www.nejm.org/doi/10.1056/...
Building a Gene-Edited CAR-T Therapeutic.
This is the oldest + best-established clinical gene editing modality: 2009 Sangamo trials in GBM (35100373) + HIV. [1/5]
www.nejm.org/doi/10.1056/...
Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV | NEJM
CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We investigated
whether site-specific modification of the gene (“gene editing”) — in this case, the
infusion of autologous CD4 T...
www.nejm.org
January 26, 2025 at 6:36 PM
"Building a CRISPR Medicine: Core Principles and Real-World Case Studies" UC Berkeley MCB290, S2025, wk1:
Building a Gene-Edited CAR-T Therapeutic.
This is the oldest + best-established clinical gene editing modality: 2009 Sangamo trials in GBM (35100373) + HIV. [1/5]
www.nejm.org/doi/10.1056/...
Building a Gene-Edited CAR-T Therapeutic.
This is the oldest + best-established clinical gene editing modality: 2009 Sangamo trials in GBM (35100373) + HIV. [1/5]
www.nejm.org/doi/10.1056/...
Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
June 24, 2025 at 10:23 PM
Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
I've been teaching my students about the delta-32 CCR5 mutation since...2017? It's a really fascinating story about how some people are naturally immune to HIV because of how specifically it binds to & enters cells. It's great to see the "next steps" in developing this into a treatment possibility!
A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to
Person functionally cured of HIV after bone marrow transplant from sibling
A man with HIV has gone into remission after receiving bone marrow from his brother, who has a rare mutation that prevents the function of receptors that HIV binds to
www.scientificamerican.com
April 13, 2026 at 11:18 PM
I've been teaching my students about the delta-32 CCR5 mutation since...2017? It's a really fascinating story about how some people are naturally immune to HIV because of how specifically it binds to & enters cells. It's great to see the "next steps" in developing this into a treatment possibility!
Curing HIV?
About 11 patients worldwide appear to have eliminated the virus after stem‑cell transplants from genetically resistant donors. This Substack explains the biology, CCR5‑Δ32, and why these cases prove possibility; but not a scalable cure.
About 11 patients worldwide appear to have eliminated the virus after stem‑cell transplants from genetically resistant donors. This Substack explains the biology, CCR5‑Δ32, and why these cases prove possibility; but not a scalable cure.
Curing HIV?
What 11 extraordinary patients can, and cannot, tell us
marcveldhoen.substack.com
April 27, 2026 at 11:37 AM
Curing HIV?
About 11 patients worldwide appear to have eliminated the virus after stem‑cell transplants from genetically resistant donors. This Substack explains the biology, CCR5‑Δ32, and why these cases prove possibility; but not a scalable cure.
About 11 patients worldwide appear to have eliminated the virus after stem‑cell transplants from genetically resistant donors. This Substack explains the biology, CCR5‑Δ32, and why these cases prove possibility; but not a scalable cure.
#10
Did you know that some people are resistant to HIV infection?
About 1% of individuals of northern European descent carry a homozygous CCR5-Δ32 mutation. CCR5 is a receptor on the surface of CD4+ T cells that helps regulate immune responses.
#FunFact #FunFactMonday
Did you know that some people are resistant to HIV infection?
About 1% of individuals of northern European descent carry a homozygous CCR5-Δ32 mutation. CCR5 is a receptor on the surface of CD4+ T cells that helps regulate immune responses.
#FunFact #FunFactMonday
March 9, 2026 at 10:03 PM
#10
Did you know that some people are resistant to HIV infection?
About 1% of individuals of northern European descent carry a homozygous CCR5-Δ32 mutation. CCR5 is a receptor on the surface of CD4+ T cells that helps regulate immune responses.
#FunFact #FunFactMonday
Did you know that some people are resistant to HIV infection?
About 1% of individuals of northern European descent carry a homozygous CCR5-Δ32 mutation. CCR5 is a receptor on the surface of CD4+ T cells that helps regulate immune responses.
#FunFact #FunFactMonday