Parapsoriasis (NOT psoriasis) and SCN9A gain of function channelopathy
September 2, 2026 at 12:45 AM
Parapsoriasis (NOT psoriasis) and SCN9A gain of function channelopathy
hmm this 80 year old demented lady who stopped eating food five weeks ago probably has a super rare channelopathy and that’s why her potassium is low, better call nephrology in the middle of the night about it
June 21, 2025 at 3:25 AM
hmm this 80 year old demented lady who stopped eating food five weeks ago probably has a super rare channelopathy and that’s why her potassium is low, better call nephrology in the middle of the night about it
bubble tea
gender-fluid
channelopathy (shout out science)
cybersurfer
mouse potato
(cyclospora is also listed 😭)
gender-fluid
channelopathy (shout out science)
cybersurfer
mouse potato
(cyclospora is also listed 😭)
Find the 5 words from your birth year that perfectly describe YOUR vibe ⬇️
www.merriam-webster.com/time-traveler/
www.merriam-webster.com/time-traveler/
July 31, 2026 at 6:03 PM
bubble tea
gender-fluid
channelopathy (shout out science)
cybersurfer
mouse potato
(cyclospora is also listed 😭)
gender-fluid
channelopathy (shout out science)
cybersurfer
mouse potato
(cyclospora is also listed 😭)
I have a particularly rare form of complex hemiplegic migraines caused by an ion channelopathy related to my Crohn's Disease. Don't ask me how it works; I just know that it's related to my Crohn's, and part of my migraine aura is paralysis, vision loss, and in bad episodes, full blown seizures.
August 26, 2025 at 4:50 PM
I have a particularly rare form of complex hemiplegic migraines caused by an ion channelopathy related to my Crohn's Disease. Don't ask me how it works; I just know that it's related to my Crohn's, and part of my migraine aura is paralysis, vision loss, and in bad episodes, full blown seizures.
🎉 New Publication in @pnas.org
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
December 30, 2025 at 7:38 AM
🎉 New Publication in @pnas.org
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Great. This is gonna fuck so many epileptics. Epidiolex has a shit formulation with a carrier oil that tends to cause liver issues. Lots of us rely on hemp CBD distillate to help with sodium channelopathy GEFS+ or even Dravet syndrome. Fml.
November 11, 2025 at 2:18 PM
Great. This is gonna fuck so many epileptics. Epidiolex has a shit formulation with a carrier oil that tends to cause liver issues. Lots of us rely on hemp CBD distillate to help with sodium channelopathy GEFS+ or even Dravet syndrome. Fml.
Every day I am feeling a little but better about having a cardiac channelopathy that could kill me at any moment.
February 27, 2025 at 1:21 PM
Every day I am feeling a little but better about having a cardiac channelopathy that could kill me at any moment.
Remarkably, families were discovered with individuals who did not seem to experience physical pain and the variation responsible was mapped to the gene for NaV 1.7.
pubmed.ncbi.nlm.nih.gov/17167479/
23/n
pubmed.ncbi.nlm.nih.gov/17167479/
23/n
An SCN9A channelopathy causes congenital inability to experience pain - PubMed
The complete inability to sense pain in an otherwise healthy individual is a very rare phenotype. In three consanguineous families from northern Pakistan, we mapped the condition as an autosomal-reces...
pubmed.ncbi.nlm.nih.gov
February 22, 2025 at 10:40 AM
Remarkably, families were discovered with individuals who did not seem to experience physical pain and the variation responsible was mapped to the gene for NaV 1.7.
pubmed.ncbi.nlm.nih.gov/17167479/
23/n
pubmed.ncbi.nlm.nih.gov/17167479/
23/n
PIP2 corrects an endothelial Piezo1 channelopathy | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
February 14, 2026 at 12:38 PM
PIP2 corrects an endothelial Piezo1 channelopathy | PNAS www.pnas.org/doi/10.1073/...
Happy 44th Birthday to Rocco Baldelli, of Woonsocket RI, who had his career derailed in 2005 by Channelopathy, which causes frequent soft tissue injuries and fatigue. He signed a FA contract with the Red Sox in 2009, and in 62 Games hit .253 with 7 HR’s. Since 2019 he has been the MGR of the Twins.
September 25, 2025 at 6:33 AM
Happy 44th Birthday to Rocco Baldelli, of Woonsocket RI, who had his career derailed in 2005 by Channelopathy, which causes frequent soft tissue injuries and fatigue. He signed a FA contract with the Red Sox in 2009, and in 62 Games hit .253 with 7 HR’s. Since 2019 he has been the MGR of the Twins.
Good interview discussing the TRPM channelopathy & the research using a T7 MRI by NCNED.
I don't appreciate the picture or the "CFS" in the headline that ABC listen used though.
I don't appreciate the picture or the "CFS" in the headline that ABC listen used though.
Researcher Prof Sonya Marshall-Gradisnik and clinician Dr Peter Smith discuss ME/CFS on an Australian radio show.
tinyurl.com/yx68vn95
tinyurl.com/yx68vn95
Chronic Fatigue Syndrome new research - ABC listen
New Australian research confirms people with ME/CFS have a consistent faulty cellular structure. Could this be a turning point in diagnosis?
tinyurl.com
January 28, 2026 at 4:11 PM
Good interview discussing the TRPM channelopathy & the research using a T7 MRI by NCNED.
I don't appreciate the picture or the "CFS" in the headline that ABC listen used though.
I don't appreciate the picture or the "CFS" in the headline that ABC listen used though.
Could a Widespread Ion Channelopathy be Causing ME/CFS, Long COVID and Gulf War Illness #MECFS #longCOVID #GWI www.healthrising.org/blog/2024/08...
Could a Widespread Ion Channelopathy be Causing ME/CFS, Long COVID and Gulf War Illness - Health Rising
Geoff’s Narrations The GIST The Blog The “transient receptor potential melastatin 3” (better known as TRPM3) saga in chronic fatigue syndrome (ME/CFS) is really something. It’s an example of one g...
www.healthrising.org
August 27, 2024 at 6:06 PM
Could a Widespread Ion Channelopathy be Causing ME/CFS, Long COVID and Gulf War Illness #MECFS #longCOVID #GWI www.healthrising.org/blog/2024/08...
1) Channelopathy
2) Cyberfurfer
3) Genderfluid
4) Deep Cut
5) Booty Call
2) Cyberfurfer
3) Genderfluid
4) Deep Cut
5) Booty Call
Find the 5 words from your birth year that perfectly describe YOUR vibe ⬇️
www.merriam-webster.com/time-traveler/
www.merriam-webster.com/time-traveler/
August 1, 2026 at 3:27 PM
1) Channelopathy
2) Cyberfurfer
3) Genderfluid
4) Deep Cut
5) Booty Call
2) Cyberfurfer
3) Genderfluid
4) Deep Cut
5) Booty Call
Don't miss this great coming meeting on channelopathies. Early bird registration until Dec 15th. #channelopathies #channelopathy #ionchannel #neuroscience #disease #physiology #pharmacology #electrophysiology #patchclamp
December 10, 2025 at 8:04 AM
Don't miss this great coming meeting on channelopathies. Early bird registration until Dec 15th. #channelopathies #channelopathy #ionchannel #neuroscience #disease #physiology #pharmacology #electrophysiology #patchclamp
Thai food just stopped my focal seizure cluster. I have complex SCN1A/SCN9A channelopathy + unitary PVNH LTMLE.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Capsaicin inhibits sodium currents and epileptiform activity in prefrontal cortex pyramidal neurons
Capsaicin, a compound found in chili peppers, causes burning sensations by acting on the peripheral sensory system. However, it has also been reported…
www.sciencedirect.com
May 2, 2026 at 1:18 AM
Thai food just stopped my focal seizure cluster. I have complex SCN1A/SCN9A channelopathy + unitary PVNH LTMLE.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Pseudoallergic MRGPRX2 mediated mast cell activation in IBS
gut.bmj.com/content/earl...
MRGPRX2 agonists trigger mast cell degranulation + transient receptor potential vanilloid 1 (TRPV1) sensitisation
While in #MyalgicE there is a channelopathy in a related TRPM3
gut.bmj.com/content/earl...
MRGPRX2 agonists trigger mast cell degranulation + transient receptor potential vanilloid 1 (TRPV1) sensitisation
While in #MyalgicE there is a channelopathy in a related TRPM3
Characterisation of MRGPRX2+ mast cells in irritable bowel syndrome
gut.bmj.com
March 21, 2025 at 12:03 PM
Pseudoallergic MRGPRX2 mediated mast cell activation in IBS
gut.bmj.com/content/earl...
MRGPRX2 agonists trigger mast cell degranulation + transient receptor potential vanilloid 1 (TRPV1) sensitisation
While in #MyalgicE there is a channelopathy in a related TRPM3
gut.bmj.com/content/earl...
MRGPRX2 agonists trigger mast cell degranulation + transient receptor potential vanilloid 1 (TRPV1) sensitisation
While in #MyalgicE there is a channelopathy in a related TRPM3
Könnte eine weit verbreitete Ionenkanalerkrankung ME/CFS, Long COVID und das Golfkriegssyndrom verursachen?
www.healthrising.org/blog/2024/08...
www.healthrising.org/blog/2024/08...
Could a Widespread Ion Channelopathy be Causing ME/CFS, Long COVID and Gulf War Illness - Health Rising
Geoff’s Narrations The GIST The Blog The “transient receptor potential melastatin 3” (better known as TRPM3) saga in chronic fatigue syndrome (ME/CFS) is really something. It’s an example of one g...
www.healthrising.org
August 21, 2024 at 2:49 PM
Könnte eine weit verbreitete Ionenkanalerkrankung ME/CFS, Long COVID und das Golfkriegssyndrom verursachen?
www.healthrising.org/blog/2024/08...
www.healthrising.org/blog/2024/08...
Transcranial magnetic stimulation can't go deep enough yet. There are other things. Need a more precise prompt 🫶 I want to answer your actual question.
I use verapamil to treat my calcium channelopathy, CBG for sodium channelopathy, levodopa + nicotine for CiNs. My PVNH houses my reading circuit.
I use verapamil to treat my calcium channelopathy, CBG for sodium channelopathy, levodopa + nicotine for CiNs. My PVNH houses my reading circuit.
June 22, 2025 at 8:03 PM
Transcranial magnetic stimulation can't go deep enough yet. There are other things. Need a more precise prompt 🫶 I want to answer your actual question.
I use verapamil to treat my calcium channelopathy, CBG for sodium channelopathy, levodopa + nicotine for CiNs. My PVNH houses my reading circuit.
I use verapamil to treat my calcium channelopathy, CBG for sodium channelopathy, levodopa + nicotine for CiNs. My PVNH houses my reading circuit.
I will definitely try this special issue of Genome Medicine for my upcoming patch clamp assay calibration for VUS interpretation in channelopathy.
We are excited to announce a call for papers for a special issue of Genome Medicine genomemedicine.biomedcentral.com on "Clinical interpretation of genome variation". The submission deadline is Dec 18, 2025. More info here: go.sn.pub/gskvsk.
Call for papers - Clinical interpretation of genome variation: volume II
go.sn.pub
March 29, 2025 at 1:34 AM
I will definitely try this special issue of Genome Medicine for my upcoming patch clamp assay calibration for VUS interpretation in channelopathy.
So Channelopathy is one I love cos I actually studied those (nearly did my masters project on them, specifically about quantum mechanics in ion channels)
I will not be explaining any of the others.
...other than to correct the typo *Cybersurfer
I will not be explaining any of the others.
...other than to correct the typo *Cybersurfer
August 1, 2026 at 3:28 PM
So Channelopathy is one I love cos I actually studied those (nearly did my masters project on them, specifically about quantum mechanics in ion channels)
I will not be explaining any of the others.
...other than to correct the typo *Cybersurfer
I will not be explaining any of the others.
...other than to correct the typo *Cybersurfer
New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan!
www.jmcc-online.com/article/S002...
🧵 1/11
www.jmcc-online.com/article/S002...
🧵 1/11
Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia
The present study aimed to characterize the SCN5A variant I1333V, found in five families
with a history of suspected catecholaminergic polymorphic ventricular tachycardia
(CPVT). SCN5A encodes the por...
www.jmcc-online.com
April 13, 2025 at 10:59 AM
New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan!
www.jmcc-online.com/article/S002...
🧵 1/11
www.jmcc-online.com/article/S002...
🧵 1/11
This team has been researching ME for the last decade.
It's awesome how they have connected the dots to arrive at this channelopathy.
Besides, there is this recent hypothesis about being too much intracellular Ca++, so maybe the puzzle is beginning to show something
It's awesome how they have connected the dots to arrive at this channelopathy.
Besides, there is this recent hypothesis about being too much intracellular Ca++, so maybe the puzzle is beginning to show something
January 13, 2026 at 11:06 AM
This team has been researching ME for the last decade.
It's awesome how they have connected the dots to arrive at this channelopathy.
Besides, there is this recent hypothesis about being too much intracellular Ca++, so maybe the puzzle is beginning to show something
It's awesome how they have connected the dots to arrive at this channelopathy.
Besides, there is this recent hypothesis about being too much intracellular Ca++, so maybe the puzzle is beginning to show something