This is my brother's research!! He's worked incredibly hard on it the last several years. I'm proud.
Science matters! Research matters!
"Time of day determines cancer immunotherapy efficacy through a circadian clock–dependent chemokine axis."
Science matters! Research matters!
"Time of day determines cancer immunotherapy efficacy through a circadian clock–dependent chemokine axis."
@biorxivpreprint.bsky.social Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 7, 2025 at 8:28 PM
This is my brother's research!! He's worked incredibly hard on it the last several years. I'm proud.
Science matters! Research matters!
"Time of day determines cancer immunotherapy efficacy through a circadian clock–dependent chemokine axis."
Science matters! Research matters!
"Time of day determines cancer immunotherapy efficacy through a circadian clock–dependent chemokine axis."
@biorxivpreprint.bsky.social Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 6, 2025 at 2:46 AM
@biorxivpreprint.bsky.social Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Not all chemokine signaling is about cell migration!
In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.
🔗 science.org/doi/10.1126/sc…#chemokinen#CXCR4R4
In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.
🔗 science.org/doi/10.1126/sc…#chemokinen#CXCR4R4
June 21, 2025 at 5:11 PM
Not all chemokine signaling is about cell migration!
In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.
🔗 science.org/doi/10.1126/sc…#chemokinen#CXCR4R4
In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.
🔗 science.org/doi/10.1126/sc…#chemokinen#CXCR4R4
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors - Nature Reviews Immunology
Nature Reviews Immunology - Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
www.nature.com
February 4, 2025 at 10:40 PM
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our new preprint is here! We show eosinophils are retained in the bone marrow by everyone’s (our😊) favourite atypical #chemokine receptor ACKR2.
#Eosinophil education of #monocytes promotes differentiation to #macrophages and bacterial elimination during E.coli #infection. Please read and share.
#Eosinophil education of #monocytes promotes differentiation to #macrophages and bacterial elimination during E.coli #infection. Please read and share.
Eosinophils promote monocyte to macrophage differentiation and anti-bacterial immunity
Chemokine receptors control cell migration within the body. Here we reveal a novel interaction between eosinophils and monocytes in the bone marrow, indirectly controlled by the atypical chemokine rec...
www.biorxiv.org
November 27, 2024 at 11:47 AM
Our new preprint is here! We show eosinophils are retained in the bone marrow by everyone’s (our😊) favourite atypical #chemokine receptor ACKR2.
#Eosinophil education of #monocytes promotes differentiation to #macrophages and bacterial elimination during E.coli #infection. Please read and share.
#Eosinophil education of #monocytes promotes differentiation to #macrophages and bacterial elimination during E.coli #infection. Please read and share.
A new #ScienceImmunology study in mice showcases a vaccine adjuvant that can induce protective immunity against herpes simplex virus 2 (HSV-2) infections without causing excessive local inflammation. https://scim.ag/3Skm7oG
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes
A chemokine–nucleic acid nanoparticle adjuvant elicits protective mucosal immunity against genital herpes simplex virus 2 infection in mice.
scim.ag
June 23, 2026 at 3:28 PM
A new #ScienceImmunology study in mice showcases a vaccine adjuvant that can induce protective immunity against herpes simplex virus 2 (HSV-2) infections without causing excessive local inflammation. https://scim.ag/3Skm7oG
Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis https://www.biorxiv.org/content/10.1101/2025.11.03.686293v1
November 4, 2025 at 9:16 PM
Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis https://www.biorxiv.org/content/10.1101/2025.11.03.686293v1
A comparison of mouse vs human tumor microenvironments shows a major difference.
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
July 7, 2025 at 5:16 AM
A comparison of mouse vs human tumor microenvironments shows a major difference.
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
Mouse TMEs have more macrophages, while human TMEs have more T cells.
Chemokine expression patterns are also different.
Learn more: www.biorxiv.org/content/10.1...
Nature research paper: Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor
https://go.nature.com/4jgtIfR
https://go.nature.com/4jgtIfR
Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor - Nature
Different phosphorylation patterns created by GRK2 and GRK5 on the C-terminal tail of ACKR3 lead to distinct structural arrangements and dynamics of G-protein-coupled receptor–arrestin complexes, potentially explaining diverse cellular outcomes.
go.nature.com
May 22, 2025 at 1:13 PM
Nature research paper: Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor
https://go.nature.com/4jgtIfR
https://go.nature.com/4jgtIfR
Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...
May 12, 2025 at 12:08 PM
Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...
New paper alert! Excited to share our latest work on the importance of inflammatory #chemokine receptors (iCCR, aka the best chemokine receptors) in mounting an optimal T cell response to #influenza infection.
Please share, happy to discuss!
Please share, happy to discuss!
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza, in this work from @mariekedoesscience.bsky.social and colleagues at @crgglasgow.bsky.social:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
June 2, 2025 at 4:07 PM
New paper alert! Excited to share our latest work on the importance of inflammatory #chemokine receptors (iCCR, aka the best chemokine receptors) in mounting an optimal T cell response to #influenza infection.
Please share, happy to discuss!
Please share, happy to discuss!
@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...
March 10, 2025 at 4:18 PM
@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...
His armpit is a chemokine receptor and my nose is a CCL21
(Kinky-Biology rizz)
(Kinky-Biology rizz)
February 12, 2025 at 10:52 AM
His armpit is a chemokine receptor and my nose is a CCL21
(Kinky-Biology rizz)
(Kinky-Biology rizz)
Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study
https://bit.ly/4fhzX0U #OpenAccess
https://bit.ly/4fhzX0U #OpenAccess
December 28, 2024 at 11:00 PM
Automated Urinary Chemokine Assays for Noninvasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study
https://bit.ly/4fhzX0U #OpenAccess
https://bit.ly/4fhzX0U #OpenAccess
7) Next, the researchers checked for neuroinflammation. Across the entire brain, there were no significant differences in cytokine and chemokine concentrations. But in the hippocampus, there were more activated microglia in infected females than in males.
October 20, 2025 at 8:14 AM
7) Next, the researchers checked for neuroinflammation. Across the entire brain, there were no significant differences in cytokine and chemokine concentrations. But in the hippocampus, there were more activated microglia in infected females than in males.
In our novel study, we report well-validated models for opioid peptide binding at the atypical chemokine receptor 3 to understand their ligand promiscuity and to provide starting points for structure-based drug design. #compchem
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Deciphering Opioid Peptide Binding Modes at Atypical Chemokine Receptor 3
ACKR3 is a class A G protein-coupled receptor that is considered as an atypical chemokine receptor. It does not activate G proteins but efficiently recruits β-arrestin and mediates ligand internalizat...
pubs.acs.org
January 1, 2026 at 7:04 PM
In our novel study, we report well-validated models for opioid peptide binding at the atypical chemokine receptor 3 to understand their ligand promiscuity and to provide starting points for structure-based drug design. #compchem
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Delighted our work on chromosomal instability in oesophageal cancer is now out in Science Advances share.google/UcZXne5OZdM9...
Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis
Chromosomal chaos rewires immune defense into tumor-promoting inflammation.
share.google
March 11, 2026 at 9:12 PM
Delighted our work on chromosomal instability in oesophageal cancer is now out in Science Advances share.google/UcZXne5OZdM9...
How does immune cell trafficking shape tumors and #Inflammation?
This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation.
#STTT #OpenAccess: doi.org/10.1038/s413...
This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation.
#STTT #OpenAccess: doi.org/10.1038/s413...
October 11, 2026 at 3:00 AM
How does immune cell trafficking shape tumors and #Inflammation?
This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation.
#STTT #OpenAccess: doi.org/10.1038/s413...
This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation.
#STTT #OpenAccess: doi.org/10.1038/s413...
“Prenatal SARS-COV-2 infection in pregnant women is linked to developmental delays in toddlers, with cytokine and chemokine changes associated with neurodevelopmental outcomes at 24 months.“
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cord blood cytokines/chemokines linked to delays in toddlers exposed to SARS-CoV-2 prenatally - Pediatric Research
Pediatric Research - Cord blood cytokines/chemokines linked to delays in toddlers exposed to SARS-CoV-2 prenatally
www.nature.com
July 18, 2025 at 11:22 AM
“Prenatal SARS-COV-2 infection in pregnant women is linked to developmental delays in toddlers, with cytokine and chemokine changes associated with neurodevelopmental outcomes at 24 months.“
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I have a theory that one reason people are suspicious of the COVID vaccine is because it causes such an active immune response and you FEEL it
Immune responses make you feel like shit! Especially if they’re strong enough to shrink or cure tumors
Immune responses make you feel like shit! Especially if they’re strong enough to shrink or cure tumors
October 24, 2025 at 4:13 AM
I have a theory that one reason people are suspicious of the COVID vaccine is because it causes such an active immune response and you FEEL it
Immune responses make you feel like shit! Especially if they’re strong enough to shrink or cure tumors
Immune responses make you feel like shit! Especially if they’re strong enough to shrink or cure tumors
Colour me absolutely unsurprised. The more we look among the respiratory (and other) viruses, the more we'll find.
'Respiratory syncytial virus infects peripheral and spinal nerves and induces chemokine-mediated neuropathy'
academic.oup.com/jid/article-...
'Respiratory syncytial virus infects peripheral and spinal nerves and induces chemokine-mediated neuropathy'
academic.oup.com/jid/article-...
January 16, 2024 at 1:12 AM
Colour me absolutely unsurprised. The more we look among the respiratory (and other) viruses, the more we'll find.
'Respiratory syncytial virus infects peripheral and spinal nerves and induces chemokine-mediated neuropathy'
academic.oup.com/jid/article-...
'Respiratory syncytial virus infects peripheral and spinal nerves and induces chemokine-mediated neuropathy'
academic.oup.com/jid/article-...
Once again, passenger mutations inherited from the 129 strain near the gene of interest lead to phenotypic issues.
In this study, absence of CCL2 in SMC seems to accelerate atherosclerosis formation. But closer examination shows this effect is due to mutations near Ccl2
tinyurl.com/SMC-CCL2-Ath...
In this study, absence of CCL2 in SMC seems to accelerate atherosclerosis formation. But closer examination shows this effect is due to mutations near Ccl2
tinyurl.com/SMC-CCL2-Ath...
Conditional deletion of Ccl2 in smooth muscle cells does not reduce early atherosclerosis in mice
C–C motif chemokine ligand 2 (CCL2) is a pro-inflammatory chemokine important for monocyte recruitment to the arterial wall and atherosclerotic plaque…
tinyurl.com
January 19, 2025 at 5:55 PM
Once again, passenger mutations inherited from the 129 strain near the gene of interest lead to phenotypic issues.
In this study, absence of CCL2 in SMC seems to accelerate atherosclerosis formation. But closer examination shows this effect is due to mutations near Ccl2
tinyurl.com/SMC-CCL2-Ath...
In this study, absence of CCL2 in SMC seems to accelerate atherosclerosis formation. But closer examination shows this effect is due to mutations near Ccl2
tinyurl.com/SMC-CCL2-Ath...
Our 1st BlueSky post and it's our lab's newest preprint! Please read and share and let us know any of your thoughts 😊 #chemokine #immunosky
Our new preprint is here! We show eosinophils are retained in the bone marrow by everyone’s (our😊) favourite atypical #chemokine receptor ACKR2.
#Eosinophil education of #monocytes promotes differentiation to #macrophages and bacterial elimination during E.coli #infection. Please read and share.
#Eosinophil education of #monocytes promotes differentiation to #macrophages and bacterial elimination during E.coli #infection. Please read and share.
Eosinophils promote monocyte to macrophage differentiation and anti-bacterial immunity
Chemokine receptors control cell migration within the body. Here we reveal a novel interaction between eosinophils and monocytes in the bone marrow, indirectly controlled by the atypical chemokine rec...
www.biorxiv.org
December 3, 2024 at 2:57 PM
Our 1st BlueSky post and it's our lab's newest preprint! Please read and share and let us know any of your thoughts 😊 #chemokine #immunosky
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza, in this work from @mariekedoesscience.bsky.social and colleagues at @crgglasgow.bsky.social:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
June 2, 2025 at 2:09 PM
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza, in this work from @mariekedoesscience.bsky.social and colleagues at @crgglasgow.bsky.social:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...