#colchicine
this is what ohioians really want
November 2, 2026 at 7:42 PM
non inferiority trial of colchicine discontinuation

placebo was NOT non inferior to colchicine for gout flares

#2026GCAN #ACR26
November 5, 2026 at 1:29 PM
Lisa Stamp - colchicine ppx for gout (prerecorded because it's 2am in NZ)

#2026GCAN #ACR26
November 5, 2026 at 1:24 PM
Colchicine flare ppx and reduced CVE

Colchicine vs NSAID flare ppx and CVE - favors colchicine

#2026GCAN #ACR26
November 5, 2026 at 2:09 PM
I’ve got Losartan, Colchicine, and Metoprolol. Can’t cool those up.
November 2, 2026 at 10:53 PM
More omics - colchicine and gene expression

#2026GCAN #ACR26
November 5, 2026 at 1:15 PM
Lessons learned: you can either have your flares early or late

But have a gout flare plan!

#2026GCAN #ACR26
November 5, 2026 at 1:38 PM
Colchicine as flare ppx for gout when starting ULT

But do we really need it??

#2026GCAN #ACR26
November 5, 2026 at 1:28 PM
2020/2021 - pandemic; but colchicine ppx RCT conducted through this time period

#GCAN2026 #ACR26
November 5, 2026 at 7:26 PM
The UK group on CV risk and colchicine ppx for gout

pubmed.ncbi.nlm.nih.gov/39708831/

#2026GCAN #ACR26
November 5, 2026 at 1:35 PM
✨Shareef Tubeileh (MS2 at VCU) - TriNetX study of age at gout dx

Later onset gout:

- higher risk of inpatient admission but lower risk of colchicine Rx.

- higher risk of MACE, ESKD, mortality

Can all be explained by comorbidity burden and age.

#2026GCAN #ACR26
November 5, 2026 at 5:19 PM
✨Colchicine Exposure Induces DNA Methylation and Expression Changes in Genes – Austin Wheeler

#2026GCAN #ACR26
November 5, 2026 at 9:54 PM
Colchicine and Perioperative Acute Kidney Injury: A Substudy of the COP-AF Randomized Clinical Trial. www.sciencedirect.com/science/arti... #hvhebron #anest
www.sciencedirect.com
November 5, 2026 at 12:19 PM
I finally found out why the govt in Ontario won't cover colchicine. They say it's for pain duh, guess who made the decision in the govt has never had chronic pericarditis or gout.
November 2, 2026 at 1:51 AM
with geneticist C. D. Darlington, they wrote monumental Chromosome Atlas of Cultivated Plants.

As a cytologist at Royal Horticultural Society at Wisley from ‘45-‘51 she researched effects of colchicine on magnolia which caused a doubling of chromosomes, giving heavier leaves, variable flowers with
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November 4, 2026 at 1:11 PM
💉Firsekibart - anti IL-1b akin to canakinumab, already approved in China

Phase 2 trial - used as flare ppx against colchicine

#2026GCAN #ACR26
November 4, 2026 at 1:20 PM
COP-AF sub study.
0.5mg colchicine BID has no effect on atrial fib or AKI following thoracic surgery.
It does, however, give one the shits.
1/2
October 31, 2026 at 1:51 AM
Other things learned from STOP GOUT

Can also learn about subclinical inflammation in gout

#2026GCAN #ACR26
November 5, 2026 at 1:11 PM
✨Brian Coburn - gout tx discontinuation among hospitalized gout pts

VA - looked at allopurinol, colchicine users

outcomes: discontinuation at admission; at discharge

factors a/w discontinuation - AKI, unit of admission

#2026GCAN #ACR26
November 5, 2026 at 6:30 PM
This UK study pointed towards colchicine flare ppx and higher risk of MI??

Could the limitations of the study design explain the results?

#2026GCAN #ACR26
November 5, 2026 at 2:11 PM
🔬 In nearly 3,000 patients having noncardiac thoracic surgery, colchicine did not reduce perioperative acute kidney injury compared with placebo, including in those with chronic kidney disease.

🎧 This Week in Nephrology: free AI briefing 👇
audioscholar.cc/feed/nephrology?w=2026-W45
Nephrology Weekly — AudioScholar
A ~10-minute, PubMed-sourced audio briefing of the week's nephrology literature. Free, every week.
audioscholar.cc
November 4, 2026 at 11:51 AM
Using UK CPRD they also did a self controlled case series study - results were null, there was no increased CV event risk after stopping flare ppx

pubmed.ncbi.nlm.nih.gov/42671134/

#2026GCAN #ACR26
November 5, 2026 at 1:37 PM
But it was intriguing that gout flares went up months 6-9 after colchicine discontinuation and then went back down

So undertook SLR and meta analysis
pubmed.ncbi.nlm.nih.gov/39711080/

#2026GCAN #ACR26
November 5, 2026 at 1:31 PM