Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.

Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.

Read the full paper: Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.

Statement of Significance: This article provides an overview of Connexin 43 hemichannels, elucidating their crucial involvement in various diseases and out

Statement of Significance: This article provides an overview of Connexin 43 hemichannels, elucidating their crucial involvement in various diseases and out

Hypoxia induces pathological remodeling in cardiomyocytes, in part by disrupting gap junction communication through Connexin43 (Cx43) phosphorylation and internalization. Here, we identify…

**Abstract:** This research introduces a novel approach to dynamically characterize the nanometer-scale reorganization of connexin43 (Cx43) tetrameric complexes within gap junctions, a crucial process governing intercellular communication. Leveraging advanced volumetric deep learning reconstruction techniques applied to super-resolution microscopy data, we develop a robust methodology capable of identifying and tracking conformational changes in Cx43 tetramers with unprecedented spatial and temporal resolution. This framework provides a quantitative tool for understanding the biophysical mechanisms regulating gap junction permeability and highlights potential therapeutic targets for diseases characterized by aberrant intercellular coupling.

Oncological patients receiving radiotherapy or chemotherapy often experience impaired wound healing due to tissue damage and cellular senescence. Connexin43 (Cx43) is a key regulator in this process, ...

Recently, accumulating preclinical findings suggest the possibility that functional abnormalities of tripartite synaptic transmission play important roles in the pathophysiology of schizophrenia and affective disorder. Therefore, to explore the novel mechanisms of mood-stabilizing effects associated …

Kherbouche, Oussama; Henning, Lukas; Niemann, Pia; et al. Neurochemical research Vol. 50, no. 5, p. 322

Microglia play a critical role in Alzheimer’s disease progression. Here, the authors show that knockout of microglial Cx43 or inhibition of Cx43 hemichannels by nanoparticle-delivered peptide mitigates cognitive deficits and neuropathology in APP/PS1 mice by inducing microglia into a neuroprotective state.

Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…