#connexin43
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haoyin.bsky.social
hiPSC-derived Blood Vessel Organoid to model Moyamoya disease

Serum Proteomics 40 case + 20 control➡️
Multiple tubulin proteins⬆️ (TUBA1A TUBA4A TUBB1 TUBB5 TUBB4B)

Recap in Moyamoya organoids

TUBA4A or TUBB4B➡️
Connexin43➡️
KLF4➡️
⏫SMC prolifer/migration

#CommsBio 2026
www.nature.com/articles/s42...
February 21, 2026 at 8:32 PM
mariamayan.bsky.social
Our latest paper in @natcomms.nature.com is here!

➡️Cx43 sensitizes BRAF-mutant tumors to BRAF/MEK inhibitors by impairing DNA repair

🔗Open access PDF: rdcu.be/euQkW
Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity
Nature Communications - Drug resistance remains a major challenge in cancer treatment. Here, the authors identify Connexin43 as target that enhances BRAF/MEKi efficacy by interfering with DNA...
rdcu.be
July 6, 2025 at 9:02 PM
A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43

rupress.org/jcb/article-...
A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43
Baum and Nguyen et al. ask how the Connexin43 gap junction channel knows how to arrive at its correct plasma membrane subdomain. They find Connexin43 mRNA
rupress.org
January 2, 2025 at 12:54 PM
diffjournal.bsky.social
NEW: The Editors-in-Chief of Differentiation, @rogerslabucd.bsky.social, @uribelab.bsky.social, and Loydie Jerome-Majewska, have curated a special collection of papers, “Osteo biology: from differentiation to regeneration.” Explore the collection: https://bit.ly/3JlXEey
Fig. 3. Effects of OPG on localization of CD44, CD47, DC-STAMP, ATP6V0D2 and Connexin43 in fusing OCs and precursors. From "Exploring the impact of osteoprotegerin on osteoclast and precursor fusion: Mechanisms and modulation by ATP," by Yunwen Peng et al.
October 22, 2025 at 5:15 PM
chillslincoln79.bsky.social
Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides forTargeted Cardiac Ischemia-Reperfusion Therapy #Connexin43 #cellcommunication #extracellularvesicles #nanovesicles #preprint #Cardiosky #Kidneydisease #cardiovascular 👇👇
biorxivpreprint.bsky.social bioRxivpreprint @biorxivpreprint.bsky.social · Jan 2
Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides forTargeted Cardiac Ischemia-Reperfusion Therapy https://www.biorxiv.org/content/10.1101/2025.01.01.630994v1
January 2, 2025 at 6:58 PM
biorxiv-cancer.bsky.social
Gap Junction Protein Connexin43 (Cx43) Promotes Glioma Invasion via the Annexin A2/MMP3 Signaling Axis https://www.biorxiv.org/content/10.64898/2026.09.14.751039v1
September 17, 2026 at 10:49 AM
kwitschas.bsky.social
New #Cx43 paper from the Leybaert group at Ghent University, Belgium!
doi.org/10.1002/glia... "Astrocyte-targeted connexin43
hemichannel inhibition prevents radiation-induced energy transporter
decrease in neurons and astrocytic proBDNF transport to synapses"
Astrocyte‐Targeted connexin43 Hemichannel Inhibition Prevents Radiation‐Induced Energy Transporter Decrease in Neurons and Astrocytic proBDNF Transport to Synapses
Brain irradiation increases astrocyte proBDNF transport, decreases neuronal GLUT3/MCT2 and is prevented by hemichannel inhibition.
doi.org
July 25, 2025 at 8:02 AM
amelie-iska.bsky.social
No, not really. They don’t form the right structure. You have to have 6. ColabFold and AlphaFold3 both do it…we need some way of limiting VRAM usage. The hemichannels are supposed to look like this…
www.rcsb.org/3d-view/7XQJ/1
3D View: 7XQJ
7XQJ: Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs (PLN conformation)
www.rcsb.org
December 2, 2024 at 7:42 AM
jmccplus.bsky.social
Looking for some weekend reading? 📜

New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43

sciencedirect.com/science/arti...
Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner
Both Nav1.5 and Cx43 are critical for the fast electrical impulse conduction in the myocardium and their reductions create the arrhythmogenic substrat…
sciencedirect.com
October 3, 2025 at 12:35 PM
rridrobot.bsky.social
RRID:Addgene_89950 was used by the authors of the Journal of Cell Biology paper "A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43".RRIDs like this improve reproducibility in scientific research. #STMpublishing #OpenScience
doi.org
January 4, 2025 at 1:11 PM
elife.bsky.social
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
CO2-dependent opening of connexin 43 hemichannels
Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.
buff.ly
July 12, 2026 at 11:26 AM
rridrobot.bsky.social
@innovativeresearch.bsky.social's resource, RRID:AB_88072, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #methodsmatter #STMpublishing #ReproducibleResearch
Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury
Read the full paper: Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury
doi.org
June 18, 2026 at 7:01 AM
mariamayan.bsky.social
‼️New paper in press, now online! @iScience_CP
Many thanks to Maria de la Fuente lab, and especially Jennifer Garcia. Always a pleasure to join forces and collaborate with them💪🏻🔬 www.cell.com/iscience/ful... @cinbio_u @uvigo.bsky.social #IDIS #IRYCIS
Nanoencapsulated Senotherapeutic Compounds Targeting Connexin-43 for Enhanced Wound Healing
Oncological patients receiving radiotherapy or chemotherapy often experience impaired wound healing due to tissue damage and cellular senescence. Connexin43 (Cx43) is a key regulator in this process, ...
www.cell.com
December 29, 2025 at 11:48 AM
amandaguitian.bsky.social
🚨 Finally out! 🚨
I’m thrilled to share that one of the papers from my doctoral thesis is now officially published in Nature Comms!

Even more exciting — it’s my first paper as a co–first author! 👩🏻‍🔬👩🏻‍💻

Huge thanks to everyone who supported us throughout this journey 🙌

🔗 www.nature.com/articles/s41...
Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity - Nature Communications
Drug resistance remains a major challenge in cancer treatment. Here, the authors identify Connexin43 as target that enhances BRAF/MEKi efficacy by interfering with DNA repair pathways, overcoming drug...
www.nature.com
July 5, 2025 at 12:15 PM
rridrobot.bsky.social
RRIDs were included in this paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #accelerateopenscience #STMpublishing
Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex
doi.org
November 29, 2025 at 8:00 AM
rridrobot.bsky.social
A paper using RRID:SCR_002037 was just published in Advanced Healthcare Materials see "Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms". We appreciate the author's support of reproducibility. #methodsmatter #accelerateopenscience
doi.org
April 5, 2025 at 7:01 AM
biorxiv-cancer.bsky.social
Increased interaction between connexin43 and microtubules is critical for glioblastoma stem-like cell maintenance and tumorigenicity. https://www.biorxiv.org/content/10.1101/2024.01.26.576347v1
Increased interaction between connexin43 and microtubules is critical for glioblastoma stem-like cell maintenance and tumorigenicity. https://www.biorxiv.org/content/10.1101/2024.01.26.576347v1
Glioblastoma (GBM) is the most common primary tumor of the central nervous system. One major challen
www.biorxiv.org
January 27, 2024 at 10:49 PM
rridrobot.bsky.social
A preprint using: Alexa Fluor 488-Affi (RRID:AB_2338057) from #JacksonImmuno was published.

SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #methodsmatter
Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury
www.biorxiv.org
April 10, 2025 at 12:00 PM
teaslime.bsky.social
Huh pubmed.ncbi.nlm.nih.gov/34070699/
Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43 - PubMed
Recently, accumulating preclinical findings suggest the possibility that functional abnormalities of tripartite synaptic transmission play important roles in the pathophysiology of schizophrenia and affective disorder. Therefore, to explore the novel mechanisms of mood-stabilizing effects associated …
pubmed.ncbi.nlm.nih.gov
November 21, 2025 at 7:13 PM
jmccardiology.bsky.social
New work in JMCC shows that Pyk2 is critical for hypoxia and adrenergic stress driven Cx43 internalization and cardiomyocyte damage.

www.jmcc-online.com/article/S002...
Inhibition of Pyk2 prevents Cx43 remodeling and cardiomyocyte injury during hypoxic and adrenergic stress
Hypoxia induces pathological remodeling in cardiomyocytes, in part by disrupting gap junction communication through Connexin43 (Cx43) phosphorylation and internalization. Here, we identify…
www.jmcc-online.com
February 4, 2026 at 4:04 PM
biorxivpreprint.bsky.social
Gap Junction Protein Connexin43 (Cx43) Promotes Glioma Invasion via the Annexin A2/MMP3 Signaling Axis https://www.biorxiv.org/content/10.64898/2026.09.14.751039v1
September 17, 2026 at 10:49 AM
bibliotecahuvh.bsky.social
Regulation of ubiquitination and degradation of the gap junction channel protein Connexin43 involves the concerted action of multiple members of the NEDD4 family of E3 ubiquitin ligases. www.sciencedirect.com/science/arti... #hvhebron #ap [Text complet]
www.sciencedirect.com
August 27, 2026 at 6:11 PM
dmmjournal.bsky.social
This Review by Bijay Guragain and colleagues examines recent developments in cardiomyocyte-based therapies for heart disease, with a particular focus on electrical coupling between graft and host tissue and the risk of graft-associated arrhythmias.

journals.biologists.com/dmm/article/...
Cardiac tissue slice showing optically mapped activation and color-coded calcium and voltage maps from a pacing site and spheroid grafts, associated CaT/Vm time traces, and immunofluorescence of the graft–host border with nuclei (DAPI), Connexin43, and sarcomeric α-actinin.
July 30, 2026 at 12:18 PM
elife.bsky.social
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
CO2-dependent opening of connexin 43 hemichannels
Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.
buff.ly
July 12, 2026 at 8:21 AM
castltrastondrs.medsky.network
- Astrocytes are key players in neuroinflammation. Increased levels of astrocyte-specific proteins (e.g., GFAP, aquaporin-4, connexin43) & astrocyte activation have been observed in ASD brains, particularly in the cerebellum
January 14, 2026 at 5:03 AM