Milk-derived nanovesicles enable oral insulin delivery by crossing the gut barrier and targeting the liver.

Atherosclerosis is the main underlying cause of death, being originated by endothelial dysfunction, which favor the recruitment of different cell type…

A recent study has investigated the potential of carrot-derived extracellular nanovesicles (CENs) as carriers for carotenoids in an in vitro model of macular degeneration. Researchers examined whether these nanovesicles, naturally occurring structures within carrots, could effectively deliver carotenoids to retinal cells affected by macular degeneration. The study focused on evaluating their ability to transport and enhance the bioavailability of these compounds, which are known for their antioxidant properties and role in maintaining eye health. The research team utilized an in vitro model simulating macular degeneration to test the efficacy of CENs as delivery vehicles. They isolated extracellular nanovesicles from carrots and loaded them with carotenoids before introducing them to retinal pigment epithelial cells under oxidative stress conditions. The findings demonstrated that CENs successfully delivered carotenoids to the target cells, where they were absorbed and utilized. Additionally, researchers observed a reduction in oxidative damage within the treated cells compared to untreated controls. These results suggest that carrot-derived nanovesicles may serve as a promising method for delivering beneficial compounds directly to retinal cells in future therapeutic applications. Newsflash | Powered by GeneOnline AI Source: GO-AI-ne1 For any suggestion and feedback, please contact us. Date: March 8, 2026...

Highlighted Article: Presentation of the first intracellular nanovesicle (INV) proteome, showing that a subset of INVs are ATG9A vesicles. This places ATG9A vesicles in a broader superfamily of traffi...

The molecular and functional characterization of the thousands of uncoated intracellular transport vesicles inside cells is a major challenge. Intracellular nanovesicles (INVs) are a large and mole...

The blood-brain barrier is the most effective security system in medicine: it keeps toxins and pathogens out of the brain, and it keeps almost every drug out with it. Biologics such as antibodies rarely reach the brain at therapeutic concentrations, a bottleneck that has frustrated attempts to treat brain disease with gene-silencing drugs. Researchers have

Targeted nanoparticles have the potential to revolutionize therapeutics for medical applications. Here, we demonstrate the utility of a flexible precision nanovesicle delivery system for functional delivery of DNA, RNA, proteins, and drugs into target cells. Nanovesicles generated by the membrane sculpting protein caveolin, termed caveospheres, can be loaded with RNA, DNA, proteins, or drugs postsynthesis or incorporate genetically encoded cargo proteins during production without the need for protein purification. Functionalized, fluorescently labeled caveospheres form a modular system that shows high stability in biological fluids and specific uptake by target-positive cells and can deliver proteins, drugs, DNA, and mRNA directly to the cytoplasm and nuclei of only the target cells. The negligible level of off-target transduction and uniform levels of targeted expression demonstrate advantages of the system over lipid-mediated gene delivery. Caveospheres can also be engineered to mimic viral particles by displaying the SARS-CoV-2-RBD protein, enabling the targeted delivery to human bronchial epithelial cells. We demonstrate their application as a targeted transfection system for cells in culture and critically, their efficacy in precision tumor killing in vivo.

Extracellular vesicles (EVs) are lipid bilayer nanovesicles that are released as ectosomes and exosomes with diversity in size and content. In this review, Kalluri examines the literature on the immun...