#checkpointblockade
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acir-org.bsky.social
Translation dysregulation may serve as a new source for identifying cancer-associated antigens, and may also help to predict responses to checkpoint blockade bit.ly/3E4OMY8 #CheckpointBlockade #CancerImmunotherapy @wellerchen.bsky.social @Samuels-lab.bsky.social  @yardenasamuels.bsky.social
April 2, 2025 at 3:55 PM
isev.org
📘Read in #JEV📘 Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy #tumorimmunotherapy #nanovesicles #checkpointblockade #pyroptosis isevjournals.onlinelibrary.wiley.com/doi/epdf/10....
September 22, 2026 at 8:44 AM
alicefrolov.bsky.social
Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade.

#TcellExhaustion #CheckpointBlockade #TumorImmunology #CD8Tcells #AntiPD1 #Tpex #ImmuneCheckpoint #CancerImmunotherapy
Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade. Figure: "Reprogramming exhausted CD8+ T cells with anti-PD-1 therapy" Subtitle: "Marker-defined transitions from terminal exhaustion toward progenitor/effector states after checkpoint blockade" The visualization employs a faceted marginal-distribution slope arrow design, functioning as a state-transition flow map. Each facet corresponds to a defined exhaustion-associated marker axis (TCF1, TOX, TIM-3, PD-1, GZMB, and Ki-67), with paired marginal distributions rendered pre- and post-treatment. Slope arrows connect the density centroids across conditions, encoding both the directionality and relative magnitude of population-level marker shifts. This approach was chosen to make explicit the differential mobilization of progenitor-exhausted (Tpex) versus terminally exhausted (Tex_term) subsets rather than collapsing the transition into a single trajectory summary. The simulated data are calibrated to reproduce trends consistent with the current literature. Under anti-PD-1, the TCF1+ TOX-intermediate progenitor compartment shows expansion accompanied by upward slope vectors in Ki-67 and GZMB, consistent with proliferative burst and reacquisition of effector potential. Concurrently, the TIM-3-high, TCF1-negative terminally differentiated fraction contracts, and its centroid displays limited displacement along the TCF1 axis, reflecting the constrained plasticity of terminally exhausted cells. This asymmetry underscores that checkpoint blockade preferentially acts on the Tpex reservoir rather than fully reverting terminal exhaustion, a distinction with direct implications for durability of response.
September 12, 2026 at 5:18 PM
springermedizin.de
Langzeitergebnisse der kleinen IMPemBra-Studie sprechen dafür, dass es sich beim fortgeschrittenen BRAF-mutierten Melanom lohnen könnte, eine kurzfristige, zusätzliche zielgerichtete Therapie zur Checkpointblockade zu ergänzen. Die eigentliche Bewährungsprobe steht indes noch aus. #medsky #Krebs
Zeitlich begrenzte zielgerichtete Behandlung als wirksames und verträgliches Add-on?
Langzeitergebnisse der kleinen IMPemBra-Studie sprechen dafür, dass es sich beim fortgeschrittenen BRAF-mutierten Melanom eventuell lohnen könnte, eine kurzfristige, zusätzliche zielgerichtete Therapie zur Checkpointblockade zu ergänzen. Die eigentliche Bewährungsprobe steht indes noch aus.
www.springermedizin.de
May 30, 2025 at 6:36 PM
moloncology.bsky.social
ℹ️ New Commentary now online

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

💡https://buff.ly/fZq4ETw

🖊️ @BcellBruno @tonyrcillo

#CheckpointBlockade #regulatoryTcells #Tcells #Tregs #Immunotherapy #ImmunoOncology
June 25, 2025 at 9:03 AM
medchemexpress.bsky.social
🔥Hot Off the Press | #Tumor #CRATERs: Hotspots of #CD8⁺ T Cell Power
🐟Using a #zebrafish #melanoma model, researchers captured CD8⁺ T cells forming “CRATERs” — #Cancer Regions of Antigen presentation & T cell Engagement and Retention.
🔗 ow.ly/m3At50XgGwE
#Tcells #CancerResearch #CheckpointBlockade
October 23, 2025 at 10:01 PM