#cooperativity
Amazing stuff from @marvintanenbaum.bsky.social!

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
#RNAsky #RNABiology
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 1, 2025 at 6:57 AM
I am extremely excited to share that I have been awarded the ERC Consolidator grant! In our project GENE-TUNE, we will build regulatory landscapes and study how enhancer distance and enhancer cooperativity shapes genes expression levels!
👏 Big congrats to Perutz group leader Christa Bücker @chribue.bsky.social on receiving the prestigious ERC Consolidator Grant! With GENE-TUNE, the Buecker lab will take a bottom-up approach to decode the complexities of gene regulatory landscapes ➡️ tinyurl.com/ybhucz3u #ERCCoG
@univie.ac.at
December 3, 2024 at 11:32 AM
Interesting new study on emergence and disruption of cooperativity in a denitrifying microbial community, by postdoc in the lab Alex Carr (from his PhD work with Nitin Baliga). academic.oup.com/ismej/articl...
Emergence and disruption of cooperativity in a denitrifying microbial community
Abstract. Anthropogenic perturbations to the nitrogen cycle, primarily through use of synthetic fertilizers, is driving an unprecedented increase in the em
academic.oup.com
June 13, 2025 at 9:09 PM
Although cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social

www.biorxiv.org/content/10.6...
May 8, 2026 at 9:10 AM
Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/

www.biorxiv.org/content/10.6...
www.biorxiv.org
May 11, 2026 at 3:30 PM
Weekly discussion section in the UCSF #BioReg class - cooperativity among lac operators, a true study in elegance of experimental design
January 22, 2025 at 3:32 PM
Excited to share DeepCompARE + ISA - a lightweight deep learning model + efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations!

Preprint: www.biorxiv.org/content/10.1...
Github: github.com/anderssonlab...
Genome-wide rules of transcription factor cooperativity revealed through in silico binding site ablation
Transcription factor (TF) cooperativity plays a critical role in gene regulation. However, the underlying genomic rules remain unclear, calling for scalable methods to characterize the TF binding site...
www.biorxiv.org
June 26, 2025 at 3:03 PM
Enhancer cooperativity can compensate for loss of activity over large genomic distances www.cell.com/molecular-ce...
Enhancer cooperativity can compensate for loss of activity over large genomic distances
Thomas, Feng, et al. introduce a synthetic platform that allows the building of complex regulatory landscapes. Integrating the same enhancer at different distances from a promoter uncovered that activ...
www.cell.com
December 3, 2024 at 2:33 AM
Single-ribosome visualization of stopless-ORF circular RNAs reveals cooperativity for rapid, efficient translation #NBThighlight www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
cell.com
February 6, 2025 at 4:24 PM
Cooperativity, dynamics, and the free-energy surfaces of charge-patterned IDPs https://www.biorxiv.org/content/10.64898/2026.05.21.726897v1
May 25, 2026 at 3:47 AM
two excellent papers on enhancer-promoter distance. Revisiting a classic unsolved problem. www.cell.com/molecular-ce... www.cell.com/molecular-ce... Wysocka and @chribue.bsky.social labs
Enhancer cooperativity can compensate for loss of activity over large genomic distances
Thomas, Feng, et al. introduce a synthetic platform that allows the building of complex regulatory landscapes. Integrating the same enhancer at different distances from a promoter uncovered that activ...
www.cell.com
December 2, 2024 at 7:30 PM
Structural Evolution of LEAFY Reveals DNA-Mediated Cooperativity and Dimerization Shifts at the Water-to-Land Transition #research #MolecularPlant cell.com/molecular-pl...
September 24, 2026 at 2:53 AM
Very nice study finding TF cooperativity driven by a specific DNA motif, and going all the way from ChiP-seq and CUT&RUN data to crystal structures and analysis of human facial variation! #Epigenetics #NeuralCrest #Cooperativity www.sciencedirect.com/science/arti...?
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-binding specificities. One mechanism for achieving re…
www.sciencedirect.com
February 2, 2024 at 3:04 PM
Enhancer cooperativity can compensate for loss of activity over large genomic distances | Molecular Cell

#chromatin #enhancers

www.cell.com/molecular-ce...
Enhancer cooperativity can compensate for loss of activity over large genomic distances
Thomas, Feng, et al. introduce a synthetic platform that allows the building of complex regulatory landscapes. Integrating the same enhancer at different distances from a promoter uncovered that activ...
www.cell.com
December 3, 2024 at 5:43 AM
Check out our latest work, accepted @jacs.acspublications.org!

We utilise dynamic cooperativity between Ni and Ga centers to activate strong C-F bonds at r.t.

Thanks to Mark and everyone @crimmingroup.bsky.social @imperialcollegeldn.bsky.social and MSCA for funding.

pubs.acs.org/jacsat/artic...
Catalytic C(sp2)–F Bond Gallylation via Dynamic Ni–Ga Cooperativity
Abstract. Bimetallic cooperative catalysis has overcome many of the established mechanistic limitations of monometallic reactivity in activating and transf
pubs.acs.org
September 28, 2026 at 1:57 PM
Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation

www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 3, 2025 at 7:38 AM
Structural Evolution of LEAFY Reveals DNA-Mediated Cooperativity and Dimerization Shifts at the Water-to-Land Transition https://www.biorxiv.org/content/10.64898/2026.04.13.717636v1
April 14, 2026 at 4:04 AM
Latest from the lab! Led by @xuening-he.bsky.social, establishing a framework for interpretation of the motif syntax of regulatory elements and a quantitative model for transcription factor cooperativity. Plenty of cool stuff revealed, including TF redundancy and synergy, and their regulatory roles!
June 26, 2025 at 5:32 PM
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 1, 2025 at 7:30 AM
100 citations each. One took a year, the other one over 10. 😅
November 22, 2024 at 11:29 AM
Patience is a virtue: How nature achieves group navigation with minimal cooperativity | PLOS Complex Systems
Patience is a virtue: How nature achieves group navigation with minimal cooperativity
Mayo AM, Carrigee C, Harrison AB, Mayo ML, Pilkiewicz KR PLOS Complex Syst 3(10): e0000136. In a famous Chinese parable, a man is shown both heaven and hell. In the latter, a group of men sit around a lavish banquet table, unable to eat because their chopsticks are too long to reach their mouths. In the former, the exact same scenario plays out, except here the men feed each other. In this paper, we compare the behavior of cockroaches to that of vibrating brush-head robots, known as bristlebots, as groups of each attempt to squeeze through a narrow passage. Although the bots and the bugs have different means of locomotion, they navigate their environment in a similar fashion. As in the parable, however, a small of amount of regard for others leads to a much happier outcome. The robots try to push past each other and form logjams that block up the passage, whereas the roaches practice patience and stop and wait for those in front of them to move through the passage first. This result may seem innocuous, but it demonstrates how simple organisms, incapable of sophisticated decision-making, require only the slightest amount of sociality to collectively solve complex problems, such as how to smoothly navigate a challenging environment as a cohesive unit.In a famous Chinese parable, a man is shown both heaven and hell. In the latter, a group of men sit around a lavish banquet table, unable to eat because their chopsticks are too long to reach their mouths. In the former, the exact same scenario plays out, except here the men feed each other. In this paper, we compare the behavior of cockroaches to that of vibrating brush-head robots, known as bristlebots, as groups of each attempt to squeeze through a narrow passage. Although the bots and the bugs have different means of locomotion, they navigate their environment in a similar fashion. As in the parable, however, a small of amount of regard for others leads to a much happier outcome. The robots try to push past each other and form logjams that block up the passage, whereas the roaches practice patience and stop and wait for those in front of them to move through the passage first. This result may seem innocuous, but it demonstrates how simple organisms, incapable of sophisticated decision-making, require only the slightest amount of sociality to collectively solve complex problems, such as how to smoothly navigate a challenging environment as a cohesive unit. Read the full article at: journals.plos.org
sco.lt
October 5, 2026 at 11:43 PM
Genome-wide rules of transcription factor cooperativity revealed through in silico binding site ablation https://www.biorxiv.org/content/10.1101/2025.06.19.660093v1
June 24, 2025 at 10:46 PM
🎉 Our latest research on valence tautomerism in 4f-organic materials is now out in @chemicalscience.rsc.org

We explore the factors driving conversion temperature, cooperativity, thermodynamics, and the magnetic & conductive properties of this fascinating, new class of materials. 🧲⚡

Read it here🔓👇
March 8, 2025 at 8:57 AM