Happy Birthday #BrentSpiner ! Cortical activity has been confirmed!
February 3, 2026 at 3:17 AM
Happy Birthday #BrentSpiner ! Cortical activity has been confirmed!
Philip K Dick movies all have names like CORTICAL IMPASSE and are based on short stories called like "Let's See What's Going On Down at the Brain Factory"
December 14, 2025 at 4:28 AM
Philip K Dick movies all have names like CORTICAL IMPASSE and are based on short stories called like "Let's See What's Going On Down at the Brain Factory"
Happy to have this published …https://www.science.org/doi/10.1126/sciadv.adr6698
A detailed theory of thalamic and cortical microcircuits for predictive visual inference
A generative vision model offers a detailed theory for cortical columns, thalamus, and computations in cortical circuits.
www.science.org
February 5, 2025 at 9:38 PM
Happy to have this published …https://www.science.org/doi/10.1126/sciadv.adr6698
Was reminded of my very favorite tweet of all time today:
December 2, 2025 at 9:26 PM
Was reminded of my very favorite tweet of all time today:
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
December 26, 2024 at 5:31 PM
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!
Rarely categorical, highly separable representations along the cortical hierarchy - Nature
Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.
www.nature.com
July 15, 2026 at 4:47 PM
Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...
July 8, 2025 at 12:00 AM
How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...
Excited to finally share our new paper in @natcomms.nature.com:
Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval
www.nature.com/articles/s41...
With @s-michelmann.bsky.social and @doellerlab.bsky.social
Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval
www.nature.com/articles/s41...
With @s-michelmann.bsky.social and @doellerlab.bsky.social
Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval - Nature Communications
How past experiences are reconstructed from memory remains unclear. Here the authors used intracranial EEG to show that hippocampal ripples reshape the geometry of cortical representations, supporting...
www.nature.com
July 24, 2026 at 9:40 PM
Excited to finally share our new paper in @natcomms.nature.com:
Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval
www.nature.com/articles/s41...
With @s-michelmann.bsky.social and @doellerlab.bsky.social
Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval
www.nature.com/articles/s41...
With @s-michelmann.bsky.social and @doellerlab.bsky.social
1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
Sensory responses of visual cortical neurons are not prediction errors
Predictive coding is theorized to be a ubiquitous cortical process to explain sensory responses. It asserts that the brain continuously predicts sensory information and imposes those predictions on lo...
www.biorxiv.org
July 11, 2025 at 3:45 PM
1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
www.biorxiv.org/content/10.1...
I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.
But...
🧠📈 🧪
This paper on how the brain may do gradient descent is very cool: www.nature.com/articles/s41...
Vectorized instructive signals in cortical dendrites - Nature
Mice learning a neurofeedback brain–computer interface task show neuron-specific teaching signals in cortical dendrites, consistent with a vectorized solution for credit assignment in the brain.
www.nature.com
February 26, 2026 at 3:02 AM
This paper on how the brain may do gradient descent is very cool: www.nature.com/articles/s41...
For #FluorescenceFriday - cortical neurons projecting to the locus coeruleus 🔵 in the mouse brain 🔬🧠🧪👩🔬
January 10, 2025 at 1:45 PM
For #FluorescenceFriday - cortical neurons projecting to the locus coeruleus 🔵 in the mouse brain 🔬🧠🧪👩🔬
Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
May 14, 2025 at 5:24 PM
Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
Interested in cortical wave dynamics? Check out our new preprint led by J Cruddas with @jchrispang.bsky.social where review the physics and physiology of cortical waves and their implications for psychological function:
osf.io/preprints/ps...
@nsb-lab.bsky.social
osf.io/preprints/ps...
@nsb-lab.bsky.social
August 2, 2025 at 3:00 AM
Interested in cortical wave dynamics? Check out our new preprint led by J Cruddas with @jchrispang.bsky.social where review the physics and physiology of cortical waves and their implications for psychological function:
osf.io/preprints/ps...
@nsb-lab.bsky.social
osf.io/preprints/ps...
@nsb-lab.bsky.social
Cortical neurons are rarely specialized (except in primary cortical areas) but still carry high-dimensional info. Here's how and why
Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy
www.biorxiv.org/content/10.1...
#neuroscience
Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy
www.biorxiv.org/content/10.1...
#neuroscience
Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy
A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently ("categorical" representations) and ...
www.biorxiv.org
February 13, 2025 at 4:22 PM
Cortical neurons are rarely specialized (except in primary cortical areas) but still carry high-dimensional info. Here's how and why
Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy
www.biorxiv.org/content/10.1...
#neuroscience
Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy
www.biorxiv.org/content/10.1...
#neuroscience
Grown-Up Bullies
bigthink.com/neuropsych/b...
bigthink.com/neuropsych/b...
Grownup bullies might literally have less brains
A study reveals these brains exhibit less cortical surface area and gray matter.
bigthink.com
April 12, 2025 at 10:41 AM
Grown-Up Bullies
bigthink.com/neuropsych/b...
bigthink.com/neuropsych/b...
‘The West Tofts handaxe is a small British Acheulean biface well known for its cortical preservation of a fossilised bivalve shell’
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
May 25, 2025 at 7:22 AM
‘The West Tofts handaxe is a small British Acheulean biface well known for its cortical preservation of a fossilised bivalve shell’
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
From a great collaboration with @lorenzoposani.com, @shuqiw.bsky.social, Samuel Muscinelli, Liam Paninski, now in Nature: www.nature.com/articles/s41...
Rarely categorical, highly separable representations along the cortical hierarchy - Nature
Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.
www.nature.com
July 15, 2026 at 3:55 PM
From a great collaboration with @lorenzoposani.com, @shuqiw.bsky.social, Samuel Muscinelli, Liam Paninski, now in Nature: www.nature.com/articles/s41...
Traveling waves. Your brain has them. There must be a reason.
Cortical traveling waves in time and space: Physics, physiology, and psychology
www.cell.com/neuron/abstr...
#neuroscience
Cortical traveling waves in time and space: Physics, physiology, and psychology
www.cell.com/neuron/abstr...
#neuroscience
Cortical traveling waves in time and space: Physics, physiology, and psychology
Cruddas et al. reviewed how core concepts from wave physics relate to cortical wave
physiology and psychology. They examined how cortical waves emerge, how they facilitate
coordinated, hierarchical, a...
www.cell.com
February 9, 2026 at 8:20 PM
Traveling waves. Your brain has them. There must be a reason.
Cortical traveling waves in time and space: Physics, physiology, and psychology
www.cell.com/neuron/abstr...
#neuroscience
Cortical traveling waves in time and space: Physics, physiology, and psychology
www.cell.com/neuron/abstr...
#neuroscience
conforme demonstramos
March 9, 2025 at 3:32 PM
conforme demonstramos
just out in Molecular Psychiatry 😍: spinal & cortical alterations in processing of self-produced sensations in psychosis
including: touch, interoception, fMRI, SEP, HEP, behavior🧠🫀
#neuroskyence
#PsychSciSky
@paulasalamone.bsky.social @adamenmalm.bsky.social @rkaldewaij.bsky.social
rdcu.be/exN0e
including: touch, interoception, fMRI, SEP, HEP, behavior🧠🫀
#neuroskyence
#PsychSciSky
@paulasalamone.bsky.social @adamenmalm.bsky.social @rkaldewaij.bsky.social
rdcu.be/exN0e
Altered processing of self-produced sensations in psychosis at cortical and spinal levels
Molecular Psychiatry - Altered processing of self-produced sensations in psychosis at cortical and spinal levels
rdcu.be
July 25, 2025 at 10:15 AM
just out in Molecular Psychiatry 😍: spinal & cortical alterations in processing of self-produced sensations in psychosis
including: touch, interoception, fMRI, SEP, HEP, behavior🧠🫀
#neuroskyence
#PsychSciSky
@paulasalamone.bsky.social @adamenmalm.bsky.social @rkaldewaij.bsky.social
rdcu.be/exN0e
including: touch, interoception, fMRI, SEP, HEP, behavior🧠🫀
#neuroskyence
#PsychSciSky
@paulasalamone.bsky.social @adamenmalm.bsky.social @rkaldewaij.bsky.social
rdcu.be/exN0e
New publication from @lukesjulson.bsky.social lab and collaborators!
#Neocortical long-range #inhibition promotes #cortical #synchrony and #sleep
doi.org/10.1038/s415...
#Neocortical long-range #inhibition promotes #cortical #synchrony and #sleep
doi.org/10.1038/s415...
Neocortical long-range inhibition promotes cortical synchrony and sleep - Nature
In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that co...
doi.org
September 9, 2026 at 4:49 PM
New publication from @lukesjulson.bsky.social lab and collaborators!
#Neocortical long-range #inhibition promotes #cortical #synchrony and #sleep
doi.org/10.1038/s415...
#Neocortical long-range #inhibition promotes #cortical #synchrony and #sleep
doi.org/10.1038/s415...
Most neurons seem to be generalists, not specialists. Cortical circuits prioritize diversity over categorical structure.
Rarely categorical, highly separable representations along the cortical hierarchy
www.nature.com/articles/s41...
#neuroscience
www.newscientist.com/article/2581...
Rarely categorical, highly separable representations along the cortical hierarchy
www.nature.com/articles/s41...
#neuroscience
www.newscientist.com/article/2581...
Rarely categorical, highly separable representations along the cortical hierarchy - Nature
Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.
www.nature.com
July 28, 2026 at 11:53 AM
Most neurons seem to be generalists, not specialists. Cortical circuits prioritize diversity over categorical structure.
Rarely categorical, highly separable representations along the cortical hierarchy
www.nature.com/articles/s41...
#neuroscience
www.newscientist.com/article/2581...
Rarely categorical, highly separable representations along the cortical hierarchy
www.nature.com/articles/s41...
#neuroscience
www.newscientist.com/article/2581...
Interested in cortical wave dynamics? Check out our review on the physics, physiology, and psychology of cortical waves led by J Cruddas with @jchrispang.bsky.social, out now in
@cp-neuron.bsky.social:
www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social:
www.sciencedirect.com/science/arti...
February 9, 2026 at 11:56 PM
Interested in cortical wave dynamics? Check out our review on the physics, physiology, and psychology of cortical waves led by J Cruddas with @jchrispang.bsky.social, out now in
@cp-neuron.bsky.social:
www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social:
www.sciencedirect.com/science/arti...
New preprint + thread 🧵
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
August 7, 2025 at 2:49 PM
New preprint + thread 🧵
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
#Psychedelics induce the formation of new synapses, but where do they connect?
Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.
www.biorxiv.org/content/10.1...
1/12
