Beautiful work - isolation of a crassphage, and turns out it is a phage-plasmid!
March 21, 2024 at 3:50 AM
Beautiful work - isolation of a crassphage, and turns out it is a phage-plasmid!
We isolated lots of #crAssphage (real #phage this time, not just computationally) and we deposited them in the ATCC.
We also used #NCI supercomputer to predict the receptors & propose crAssphage uses the TonB receptor
#microsky #microbiomesky
www.microbiologyresearch.org/content/jour...
We also used #NCI supercomputer to predict the receptors & propose crAssphage uses the TonB receptor
#microsky #microbiomesky
www.microbiologyresearch.org/content/jour...
Host interactions of novel Crassvirales species belonging to multiple families infecting bacterial h...
Bacteroides, the prominent bacteria in the human gut, play a crucial role in degrading complex polysaccharides. Their abundance is influenced by phages belonging to the Crassvirales order. Despite ide...
www.microbiologyresearch.org
October 1, 2023 at 12:03 PM
We isolated lots of #crAssphage (real #phage this time, not just computationally) and we deposited them in the ATCC.
We also used #NCI supercomputer to predict the receptors & propose crAssphage uses the TonB receptor
#microsky #microbiomesky
www.microbiologyresearch.org/content/jour...
We also used #NCI supercomputer to predict the receptors & propose crAssphage uses the TonB receptor
#microsky #microbiomesky
www.microbiologyresearch.org/content/jour...
#PapersBiologiaUB |💧El marcador víric #crAssphage destaca com a eina eficient per detectar contaminació fecal d’origen humà en diversos entorns i climes, amb importants aplicacions per a la #salutpública.
📝 Participa @putxinelli.bsky.social
www.sciencedirect.com/science/arti...
📝 Participa @putxinelli.bsky.social
www.sciencedirect.com/science/arti...
April 25, 2025 at 11:29 AM
#PapersBiologiaUB |💧El marcador víric #crAssphage destaca com a eina eficient per detectar contaminació fecal d’origen humà en diversos entorns i climes, amb importants aplicacions per a la #salutpública.
📝 Participa @putxinelli.bsky.social
www.sciencedirect.com/science/arti...
📝 Participa @putxinelli.bsky.social
www.sciencedirect.com/science/arti...
CrAssphage dethroned as most most abundant extrachromosomal genetic element in the human gut! #microbiome @linsalrob.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A cryptic plasmid is among the most numerous genetic elements in the human gut
Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing features. However, many bacteria carry “cryptic” plasmids that do n…
www.sciencedirect.com
March 3, 2024 at 11:58 PM
CrAssphage dethroned as most most abundant extrachromosomal genetic element in the human gut! #microbiome @linsalrob.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Study highlights crAssphage markers as superior tools for detecting human faecal contamination in surface water, offering insights for environmental monitoring. #WaterPollution #CrAssphage #EnvironmentalHealth #MicrobialSourceTracking
📄 doi.org/10.1016/j.en...
EVBC👤: @evelienadri.bsky.social
📄 doi.org/10.1016/j.en...
EVBC👤: @evelienadri.bsky.social
Redirecting
doi.org
December 3, 2024 at 10:43 AM
Study highlights crAssphage markers as superior tools for detecting human faecal contamination in surface water, offering insights for environmental monitoring. #WaterPollution #CrAssphage #EnvironmentalHealth #MicrobialSourceTracking
📄 doi.org/10.1016/j.en...
EVBC👤: @evelienadri.bsky.social
📄 doi.org/10.1016/j.en...
EVBC👤: @evelienadri.bsky.social
In August of 2025, Stanford researchers, Ami Bhatt, Gavin Sherlock & graduate student Danica Schmidtke, made a landmark discovery in microbiome science — successfully isolating p-crAssphage, the most abundant virus in the human gut, for the first time. https://stanford.io/4fzpfEV #25MomentsOf2025
November 26, 2025 at 6:13 PM
In August of 2025, Stanford researchers, Ami Bhatt, Gavin Sherlock & graduate student Danica Schmidtke, made a landmark discovery in microbiome science — successfully isolating p-crAssphage, the most abundant virus in the human gut, for the first time. https://stanford.io/4fzpfEV #25MomentsOf2025
ICYMI: New online! Plasmid and phage lifestyles in crAssphage
Plasmid and phage lifestyles in crAssphage
Nature Reviews Microbiology, Published online: 05 August 2025; doi:10.1038/s41579-025-01229-zThis study shows that the prototypical crAssphage Carjivirus communis replicates as a low-copy, linear phage–plasmid that has a broad host range.
www.nature.com
August 12, 2025 at 12:27 PM
ICYMI: New online! Plasmid and phage lifestyles in crAssphage
Analysis and culturing of the prototypic crAssphage reveals a phage-plasmid lifestyle https://www.biorxiv.org/content/10.1101/2024.03.20.585998v1
Analysis and culturing of the prototypic crAssphage reveals a phage-plasmid lifestyle https://www.biorxiv.org/content/10.1101/2024.03.20.585998v1
The prototypic crAssphage (Carjivirus communis) is one of the most abundant, prevalent, and persiste
www.biorxiv.org
March 21, 2024 at 3:17 AM
Analysis and culturing of the prototypic crAssphage reveals a phage-plasmid lifestyle https://www.biorxiv.org/content/10.1101/2024.03.20.585998v1
The prototypic crAssphage is a linear phage-plasmid
New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range
www.cell.com/cell-host-mi...
New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range
www.cell.com/cell-host-mi...
The prototypic crAssphage is a linear phage-plasmid
Schmidtke et al. demonstrate that C. communis, a ubiquitous human gut phage that evades
conventional plaque-based isolation, predominately replicates as a low-copy linear
phage-plasmid with a broad ho...
www.cell.com
July 28, 2025 at 8:13 PM
The prototypic crAssphage is a linear phage-plasmid
New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range
www.cell.com/cell-host-mi...
New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range
www.cell.com/cell-host-mi...
I believe it. The lesson I recall from the crassphage discovery paper that multi-sample assembly reduces recall.
April 14, 2026 at 11:33 AM
I believe it. The lesson I recall from the crassphage discovery paper that multi-sample assembly reduces recall.
human microbiome:
crassphage: www.nature.com/articles/nco...
TMAO: pmc.ncbi.nlm.nih.gov/articles/PMC...
Impact on immunotherapy: pubmed.ncbi.nlm.nih.gov/36464584/
IgA interactions: www.nature.com/articles/s41...
Akkermansia: www.nature.com/articles/s41...
this: www.nejm.org/doi/full/10....
crassphage: www.nature.com/articles/nco...
TMAO: pmc.ncbi.nlm.nih.gov/articles/PMC...
Impact on immunotherapy: pubmed.ncbi.nlm.nih.gov/36464584/
IgA interactions: www.nature.com/articles/s41...
Akkermansia: www.nature.com/articles/s41...
this: www.nejm.org/doi/full/10....
March 20, 2025 at 1:50 PM
human microbiome:
crassphage: www.nature.com/articles/nco...
TMAO: pmc.ncbi.nlm.nih.gov/articles/PMC...
Impact on immunotherapy: pubmed.ncbi.nlm.nih.gov/36464584/
IgA interactions: www.nature.com/articles/s41...
Akkermansia: www.nature.com/articles/s41...
this: www.nejm.org/doi/full/10....
crassphage: www.nature.com/articles/nco...
TMAO: pmc.ncbi.nlm.nih.gov/articles/PMC...
Impact on immunotherapy: pubmed.ncbi.nlm.nih.gov/36464584/
IgA interactions: www.nature.com/articles/s41...
Akkermansia: www.nature.com/articles/s41...
this: www.nejm.org/doi/full/10....
Meet p-crAssphage, the most common virus in the human gut — now isolated for the first time by Stanford researchers. Read more in this new Q&A with #StanDOM researchers Ami Bhatt, MD, PhD, Gavin Sherlock, PhD & graduate student Danica Schmidtke: stanford.io/4fzpfEV
#microbiome
#microbiome
August 14, 2025 at 8:53 PM
Meet p-crAssphage, the most common virus in the human gut — now isolated for the first time by Stanford researchers. Read more in this new Q&A with #StanDOM researchers Ami Bhatt, MD, PhD, Gavin Sherlock, PhD & graduate student Danica Schmidtke: stanford.io/4fzpfEV
#microbiome
#microbiome
What is genomic structure & lifecycle of crAssphage & how does it persist & replicate in gut bacteria?
Its a linear DNA element with phage & plasmid features, persisting as infectious virus and stable plasmid form, explaining its abundance & coexistence w/o host integration. doi.org/10.1016/j.ch...
Its a linear DNA element with phage & plasmid features, persisting as infectious virus and stable plasmid form, explaining its abundance & coexistence w/o host integration. doi.org/10.1016/j.ch...
The prototypic crAssphage is a linear phage-plasmid
Schmidtke et al. demonstrate that C. communis, a ubiquitous human gut phage that evades
conventional plaque-based isolation, predominately replicates as a low-copy linear
phage-plasmid with a broad ho...
www.cell.com
August 1, 2025 at 11:29 AM
What is genomic structure & lifecycle of crAssphage & how does it persist & replicate in gut bacteria?
Its a linear DNA element with phage & plasmid features, persisting as infectious virus and stable plasmid form, explaining its abundance & coexistence w/o host integration. doi.org/10.1016/j.ch...
Its a linear DNA element with phage & plasmid features, persisting as infectious virus and stable plasmid form, explaining its abundance & coexistence w/o host integration. doi.org/10.1016/j.ch...
Fantastic piece of research that discovered the atypical lifestyle of the prototypic crAssphage. This project showcased so much determination, brilliance, and open-mindedness, proving that great discoveries are made by following the evidence wherever it leads.
The prototypic crAssphage is a linear phage-plasmid
New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range
www.cell.com/cell-host-mi...
New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range
www.cell.com/cell-host-mi...
The prototypic crAssphage is a linear phage-plasmid
Schmidtke et al. demonstrate that C. communis, a ubiquitous human gut phage that evades
conventional plaque-based isolation, predominately replicates as a low-copy linear
phage-plasmid with a broad ho...
www.cell.com
August 15, 2025 at 7:58 AM
Fantastic piece of research that discovered the atypical lifestyle of the prototypic crAssphage. This project showcased so much determination, brilliance, and open-mindedness, proving that great discoveries are made by following the evidence wherever it leads.
Congratulations to Ciara Tobin (and my co-supervisor @AShkoporov) on conducting her PhD viva today. We’re so proud of what she’s done on crAssphage across multiple disciplines. @apcmicrobiomeirel.bsky.social @uccmicrobiology.bsky.social
May 19, 2025 at 1:00 PM
Congratulations to Ciara Tobin (and my co-supervisor @AShkoporov) on conducting her PhD viva today. We’re so proud of what she’s done on crAssphage across multiple disciplines. @apcmicrobiomeirel.bsky.social @uccmicrobiology.bsky.social
Find out why normalising an RNA target in wastewater using controls such as Pepper Mild Mottle Virus or crAssphage might make matters worse. jrepstat.fairpressjournals.com/articles/nor... #wbe #wastewater
Normalizing RNA concentrations in wastewater using a control without public health data — Journal of Reproducible Statistics
PCR-based measurement of RNA targets in wastewater epidemiology is subject to substantial variation, resulting in considerable uncertainty in disease prevalence estimates.
jrepstat.fairpressjournals.com
September 30, 2026 at 11:09 AM
Find out why normalising an RNA target in wastewater using controls such as Pepper Mild Mottle Virus or crAssphage might make matters worse. jrepstat.fairpressjournals.com/articles/nor... #wbe #wastewater
A great story about how @npbhavya.bsky.social analysed a lot of #crAssphage genomes we isolated. This was a hugely collaborative effort including friends around the world!
#phagesky 🦠🧫🧪
microbiologysociety.org/blog/a-journ...
#phagesky 🦠🧫🧪
microbiologysociety.org/blog/a-journ...
A Journey into Crassvirales phages and Bacteroides bacteria
Bhavya Papudeshi takes us behind the scenes of their latest publication, '<a href="https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.001100">Host interactions of novel ...
microbiologysociety.org
October 27, 2023 at 12:32 AM
A great story about how @npbhavya.bsky.social analysed a lot of #crAssphage genomes we isolated. This was a hugely collaborative effort including friends around the world!
#phagesky 🦠🧫🧪
microbiologysociety.org/blog/a-journ...
#phagesky 🦠🧫🧪
microbiologysociety.org/blog/a-journ...
Das andere ist CrAssphage und ein normaler Darmbewohner unabhängig von der Ernährung (soweit ich weiß).
Der Name kommt übrigens von Cross Assembly, weil das Genom aus Metagenomstudien zusammengebastelt wurde.
Der Name kommt übrigens von Cross Assembly, weil das Genom aus Metagenomstudien zusammengebastelt wurde.
March 2, 2024 at 10:15 PM
Das andere ist CrAssphage und ein normaler Darmbewohner unabhängig von der Ernährung (soweit ich weiß).
Der Name kommt übrigens von Cross Assembly, weil das Genom aus Metagenomstudien zusammengebastelt wurde.
Der Name kommt übrigens von Cross Assembly, weil das Genom aus Metagenomstudien zusammengebastelt wurde.
New online! Plasmid and phage lifestyles in crAssphage
Plasmid and phage lifestyles in crAssphage
Nature Reviews Microbiology, Published online: 05 August 2025; doi:10.1038/s41579-025-01229-zThis study shows that the prototypical crAssphage Carjivirus communis replicates as a low-copy, linear phage–plasmid that has a broad host range.
www.nature.com
August 5, 2025 at 12:26 PM
New online! Plasmid and phage lifestyles in crAssphage
Stanford researchers just achieved another 1st: Using ProxiMeta™, helped isolate p-crAssphage, a common gut virus and shape shifter that can switch between producing viruses and quietly living in bacteria like a plasmid. Read more in @cp-cellhostmicrobe.bsky.social: www.cell.com/cell-host-mi...
August 19, 2025 at 4:15 PM
Stanford researchers just achieved another 1st: Using ProxiMeta™, helped isolate p-crAssphage, a common gut virus and shape shifter that can switch between producing viruses and quietly living in bacteria like a plasmid. Read more in @cp-cellhostmicrobe.bsky.social: www.cell.com/cell-host-mi...
Join #MVIF 42
cassyni.com/s/mvif-42
and #MeetTheSpeakers
🇺🇸 Danica Schmidtke will talk about the prototypic crAssphage (Carjivirus communis)!
cassyni.com/s/mvif-42
and #MeetTheSpeakers
🇺🇸 Danica Schmidtke will talk about the prototypic crAssphage (Carjivirus communis)!
October 9, 2025 at 7:52 AM
Join #MVIF 42
cassyni.com/s/mvif-42
and #MeetTheSpeakers
🇺🇸 Danica Schmidtke will talk about the prototypic crAssphage (Carjivirus communis)!
cassyni.com/s/mvif-42
and #MeetTheSpeakers
🇺🇸 Danica Schmidtke will talk about the prototypic crAssphage (Carjivirus communis)!
Here are the accession numbers from #atcc for crAssphage
ATCC® BAA-3231-B1 Kehishuvirus tikkala Strain: Bc01
ATCC® BAA-3231-B2 Kolpuevirus frurule Strain: Bc03
ATCC® BAA-3231-B3 Rudgehvirus jaberico Strain: Bc11
ATCC® BAA-3231-B1 Kehishuvirus tikkala Strain: Bc01
ATCC® BAA-3231-B2 Kolpuevirus frurule Strain: Bc03
ATCC® BAA-3231-B3 Rudgehvirus jaberico Strain: Bc11
October 1, 2023 at 12:09 PM
Here are the accession numbers from #atcc for crAssphage
ATCC® BAA-3231-B1 Kehishuvirus tikkala Strain: Bc01
ATCC® BAA-3231-B2 Kolpuevirus frurule Strain: Bc03
ATCC® BAA-3231-B3 Rudgehvirus jaberico Strain: Bc11
ATCC® BAA-3231-B1 Kehishuvirus tikkala Strain: Bc01
ATCC® BAA-3231-B2 Kolpuevirus frurule Strain: Bc03
ATCC® BAA-3231-B3 Rudgehvirus jaberico Strain: Bc11
If I have to call carjivirus by it's government name then fine but that guy will always be crAssphage in my heart
December 4, 2024 at 3:24 AM
If I have to call carjivirus by it's government name then fine but that guy will always be crAssphage in my heart