What are your feelings toward latex? The tingly feeling isn’t supposed to be an additional feature.
Cross-reactivity explained:
Cross-reactivity explained:
March 24, 2026 at 4:39 PM
What are your feelings toward latex? The tingly feeling isn’t supposed to be an additional feature.
Cross-reactivity explained:
Cross-reactivity explained:
Remember? Mysterious Pediatric hepatitis of unknown etiology?
Well 🥺
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
H/T @harryspoelstra.bsky.social
www.sciencedirect.com/science/arti...
Well 🥺
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
H/T @harryspoelstra.bsky.social
www.sciencedirect.com/science/arti...
September 30, 2023 at 12:10 PM
Remember? Mysterious Pediatric hepatitis of unknown etiology?
Well 🥺
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
H/T @harryspoelstra.bsky.social
www.sciencedirect.com/science/arti...
Well 🥺
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
H/T @harryspoelstra.bsky.social
www.sciencedirect.com/science/arti...
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
MedSky
MedSky
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
www.sciencedirect.com
September 30, 2023 at 10:47 PM
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
MedSky
MedSky
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
November 20, 2024 at 9:55 AM
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
Remember all that "mysterious" pediatric hepatitis of "unknown etiology?"
Turns out the "alarmists" were right. It was Covid.
www.sciencedirect.com/science/arti...
Turns out the "alarmists" were right. It was Covid.
www.sciencedirect.com/science/arti...
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
www.sciencedirect.com
September 30, 2023 at 3:11 PM
Remember all that "mysterious" pediatric hepatitis of "unknown etiology?"
Turns out the "alarmists" were right. It was Covid.
www.sciencedirect.com/science/arti...
Turns out the "alarmists" were right. It was Covid.
www.sciencedirect.com/science/arti...
Excited to share our new paper out today in @natcomms.nature.com
Combining multiplex serology, mathematical modelling, and experimental validation reveals arbovirus transmission dynamics despite cross-reactivity. (1/2)
Combining multiplex serology, mathematical modelling, and experimental validation reveals arbovirus transmission dynamics despite cross-reactivity. (1/2)
Investigating antibody cross-reactivity and transmission dynamics of alphaviruses and flaviviruses using a multiplex serological assay - Nature Communications
Arboviruses often co-circulate, but cross-reactivity hampers serological diagnostics. Here, the authors paired multiplex serology with competitive immunoassays and Bayesian modelling to quantify antib...
www.nature.com
April 15, 2026 at 6:51 PM
Excited to share our new paper out today in @natcomms.nature.com
Combining multiplex serology, mathematical modelling, and experimental validation reveals arbovirus transmission dynamics despite cross-reactivity. (1/2)
Combining multiplex serology, mathematical modelling, and experimental validation reveals arbovirus transmission dynamics despite cross-reactivity. (1/2)
Cross-reactivity of beta-lactams. A review of the beta-lactam cross-reactivity patterns based on key pharmacological structures and known clinical cross-reactivity #idsky
November 6, 2025 at 8:35 PM
Cross-reactivity of beta-lactams. A review of the beta-lactam cross-reactivity patterns based on key pharmacological structures and known clinical cross-reactivity #idsky
NOTE: you'll see me probably list methylisothiazolinone, methylchloroisothiazolinone, benzisothiazoline and MBIT (2-Methyl-1,2-benzothiazol-3(2H)-one) during this; my understanding is they're the same family and cross-reactivity is common. Winsor Newton's regulatory department told me as much, too
March 6, 2026 at 6:54 PM
NOTE: you'll see me probably list methylisothiazolinone, methylchloroisothiazolinone, benzisothiazoline and MBIT (2-Methyl-1,2-benzothiazol-3(2H)-one) during this; my understanding is they're the same family and cross-reactivity is common. Winsor Newton's regulatory department told me as much, too
Hepatitis: www.sciencedirect.com/science/arti...
T cell cross-reactivity in autoimmune-like hepatitis triggered by COVID-19
www.sciencedirect.com
April 25, 2024 at 6:33 AM
Hepatitis: www.sciencedirect.com/science/arti...
More good news about the BA.2.86 variant, from great work by Ben Murrell and colleagues at Karolinska Institute, adding to its low cell infectivity reported yesterday
Some unanticipated cross-reactivity of XBB.1.5 antibodies, which forecasts better for the new booster 🧪
Some unanticipated cross-reactivity of XBB.1.5 antibodies, which forecasts better for the new booster 🧪
September 2, 2023 at 1:37 AM
More good news about the BA.2.86 variant, from great work by Ben Murrell and colleagues at Karolinska Institute, adding to its low cell infectivity reported yesterday
Some unanticipated cross-reactivity of XBB.1.5 antibodies, which forecasts better for the new booster 🧪
Some unanticipated cross-reactivity of XBB.1.5 antibodies, which forecasts better for the new booster 🧪
Excellent discussion by Daniel Park of 3 recent papers on the Novavax SARSCoV2 vaccine. Better durability and cross reactivity and milder side effects than RNA vax.
That's the way it appeared from early data, but it's good to see that confirmed.
threadreaderapp.com/thread/18576...
That's the way it appeared from early data, but it's good to see that confirmed.
threadreaderapp.com/thread/18576...
Thread by @Daniel_E_Park on Thread Reader App
@Daniel_E_Park: A trio of Novavax preprints, showing 1) remarkable durability >6 months, 2) cross protection against newer variants, and 3) low reactogenicity (side effects), supporting NVX as an exce...
threadreaderapp.com
November 17, 2024 at 7:51 AM
Excellent discussion by Daniel Park of 3 recent papers on the Novavax SARSCoV2 vaccine. Better durability and cross reactivity and milder side effects than RNA vax.
That's the way it appeared from early data, but it's good to see that confirmed.
threadreaderapp.com/thread/18576...
That's the way it appeared from early data, but it's good to see that confirmed.
threadreaderapp.com/thread/18576...
Ebola virus vaccination elicits Ebola virus–specific immune responses without substantial cross-reactivity to other filoviruses www.science.org/doi/10.1126/...
Ebola virus vaccination elicits Ebola virus–specific immune responses without substantial cross-reactivity to other filoviruses
The Ad26/MVA Ebola virus vaccine elicited coordinated antibody and T cell responses that recognized Ebola virus but rarely other filoviruses.
www.science.org
May 22, 2026 at 1:54 PM
Ebola virus vaccination elicits Ebola virus–specific immune responses without substantial cross-reactivity to other filoviruses www.science.org/doi/10.1126/...
Studie bestätigt direkten Zusammenhang mit Hepatitis und SarsCov2.
Wer ab jetzt wieder über Korrelation, milde Leber- Transplantationen in dem Zusammenhang o.ä. schwurbelt, wird ohne weitere Anmerkung geblockt.
Mit musikalischen Grüßen.
t.co/tJRcwOZ1Ay
Wer ab jetzt wieder über Korrelation, milde Leber- Transplantationen in dem Zusammenhang o.ä. schwurbelt, wird ohne weitere Anmerkung geblockt.
Mit musikalischen Grüßen.
t.co/tJRcwOZ1Ay
T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19
t.co
September 30, 2023 at 12:07 PM
Studie bestätigt direkten Zusammenhang mit Hepatitis und SarsCov2.
Wer ab jetzt wieder über Korrelation, milde Leber- Transplantationen in dem Zusammenhang o.ä. schwurbelt, wird ohne weitere Anmerkung geblockt.
Mit musikalischen Grüßen.
t.co/tJRcwOZ1Ay
Wer ab jetzt wieder über Korrelation, milde Leber- Transplantationen in dem Zusammenhang o.ä. schwurbelt, wird ohne weitere Anmerkung geblockt.
Mit musikalischen Grüßen.
t.co/tJRcwOZ1Ay
Was ich es hasse recht zu behalten -"T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19 "https://www.sciencedirect.com/science/article/pii/S2949928323000093
Und ihr habt über ein Jahr nichts gemacht - oh wait - ausser Kinder durchseuchen - @c_lindner @Karl_Lauterbach
Und ihr habt über ein Jahr nichts gemacht - oh wait - ausser Kinder durchseuchen - @c_lindner @Karl_Lauterbach
September 30, 2023 at 4:32 PM
Was ich es hasse recht zu behalten -"T Cell Cross-reactivity in Autoimmune-like Hepatitis Triggered by COVID-19 "https://www.sciencedirect.com/science/article/pii/S2949928323000093
Und ihr habt über ein Jahr nichts gemacht - oh wait - ausser Kinder durchseuchen - @c_lindner @Karl_Lauterbach
Und ihr habt über ein Jahr nichts gemacht - oh wait - ausser Kinder durchseuchen - @c_lindner @Karl_Lauterbach
Even if, as Pelech claims, you computationally select peptides that are not conserved across flu subtypes, you will likely have cross-reactivity. Peptides are not always structurally like the full protein so you get off-target binding & flu is notoriously cross-reactive.
October 9, 2025 at 11:38 AM
Even if, as Pelech claims, you computationally select peptides that are not conserved across flu subtypes, you will likely have cross-reactivity. Peptides are not always structurally like the full protein so you get off-target binding & flu is notoriously cross-reactive.
Quantitative and large-scale investigation of human TCR-HLA cross-reactivity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Quantitative and large-scale investigation of human TCR-HLA cross-reactivity
TCR-based HLA similarity network reveals hidden cross-reactivity among HLA types and its role in disease and transplantation.
www.science.org
October 24, 2025 at 8:50 PM
Quantitative and large-scale investigation of human TCR-HLA cross-reactivity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
…sort of, because with flu you can still get cross-reactivity from other HA subtypes. To be really sure you need to deplete other subtypes’ antibodies from your sample before testing. Otherwise you STILL have cross-reactivity. Best to validate results by another method.
October 9, 2025 at 11:38 AM
…sort of, because with flu you can still get cross-reactivity from other HA subtypes. To be really sure you need to deplete other subtypes’ antibodies from your sample before testing. Otherwise you STILL have cross-reactivity. Best to validate results by another method.
🚀 Our new Publication in Nature Biomedical Engineering!🎉
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors - Nature Biomedical Engineering
This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity ...
www.nature.com
January 5, 2026 at 10:46 AM
🚀 Our new Publication in Nature Biomedical Engineering!🎉
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
🔗 Read the full paper here: www.nature.com/articles/s41...
Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.
www.science.org
February 7, 2025 at 7:40 PM
Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...
here in bluesky continuing on #TCR and #Crossreactivity -another great paper by Andrew McMichael -"Extent of T cell cross-reactivity presents a paradox; there is evidence that T cells are broadly cross-reactive, but other data show narrow specificities" rupress.org/jem/article-...
T Cell Cross-Reactivity and Conformational Changes during TCR Engagement | Journal of Experimental Medicine | Rockefeller University Press
rupress.org
November 21, 2024 at 5:32 PM
here in bluesky continuing on #TCR and #Crossreactivity -another great paper by Andrew McMichael -"Extent of T cell cross-reactivity presents a paradox; there is evidence that T cells are broadly cross-reactive, but other data show narrow specificities" rupress.org/jem/article-...
Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!
T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database
Banerjee et al. present a comprehensive T cell receptor cross-reactivity database
and a hierarchical Bayesian framework to predict T cell receptor targets. Together,
they reveal structural and biochem...
www.cell.com
July 25, 2025 at 3:00 PM
Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!
Anyway, if anyone else needs the citation, the best one I found for it is pubmed.ncbi.nlm.nih.gov/20838187/
Rapid urine drug screens: diphenhydramine and methadone cross-reactivity - PubMed
Rapid urine drug screens using immunoassays based on the principle of competitive binding may show false-positive methadone results for patients who have ingested DPH. Product information for urine dr...
pubmed.ncbi.nlm.nih.gov
October 20, 2024 at 6:16 AM
Anyway, if anyone else needs the citation, the best one I found for it is pubmed.ncbi.nlm.nih.gov/20838187/
Researchers in Science #Immunology have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 #H5N1.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.
www.science.org
February 9, 2025 at 4:08 PM
Researchers in Science #Immunology have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 #H5N1.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
unique side chain! <1% cross-reactivity!!
March 28, 2026 at 12:10 AM
unique side chain! <1% cross-reactivity!!