It's either you like Marvel movies or art films. I dunno man I don't really like either. I exist in the weird cytoplasm surrounding all that, the foreign films that aren't cool to like and the indie productions whose flaws are a little too hard to ignore.
November 3, 2026 at 4:54 AM
It's either you like Marvel movies or art films. I dunno man I don't really like either. I exist in the weird cytoplasm surrounding all that, the foreign films that aren't cool to like and the indie productions whose flaws are a little too hard to ignore.
I have an important paper in Scientific Reports. What happens to me if the journal is delisted? #Cyanide 🧪 #Raman
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 31, 2026 at 9:23 PM
I have an important paper in Scientific Reports. What happens to me if the journal is delisted? #Cyanide 🧪 #Raman
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🚀 Excited to share our new study in Science Advances!
🔬We reveal a direct link between cytoplasmic concentration and intracellular mechanics in epithelial tissues!
👏 Fantastic work by Gregory Arkowitz!
🤝Great collaboration with JF. Berret and Gilles Tessier.
🔗 www.science.org/doi/10.1126/...
🔬We reveal a direct link between cytoplasmic concentration and intracellular mechanics in epithelial tissues!
👏 Fantastic work by Gregory Arkowitz!
🤝Great collaboration with JF. Berret and Gilles Tessier.
🔗 www.science.org/doi/10.1126/...
Cytoplasmic crowding drives intracellular viscoelastic increase during epithelial maturation
The cytoplasm is a crowded, active medium whose mechanical properties underpin essential cellular functions, yet how intracellular rheology adapts during tissue maturation remains unclear. Here, we ex...
www.science.org
November 4, 2026 at 10:27 PM
🚀 Excited to share our new study in Science Advances!
🔬We reveal a direct link between cytoplasmic concentration and intracellular mechanics in epithelial tissues!
👏 Fantastic work by Gregory Arkowitz!
🤝Great collaboration with JF. Berret and Gilles Tessier.
🔗 www.science.org/doi/10.1126/...
🔬We reveal a direct link between cytoplasmic concentration and intracellular mechanics in epithelial tissues!
👏 Fantastic work by Gregory Arkowitz!
🤝Great collaboration with JF. Berret and Gilles Tessier.
🔗 www.science.org/doi/10.1126/...
4/5 That arithmetic assumes a clean elastic beam in water. Real cytoplasm is viscous, warm and crowded — damping smothers the vibration almost immediately. The review is careful: this is a prediction about a structure, not evidence of a cellular signal.
November 4, 2026 at 8:19 PM
4/5 That arithmetic assumes a clean elastic beam in water. Real cytoplasm is viscous, warm and crowded — damping smothers the vibration almost immediately. The review is careful: this is a prediction about a structure, not evidence of a cellular signal.
In this paper, they found that people with pathogenic variants in KRT9 experienced elevated levels of nuclear-localized YAP1. Mechanistically, they found that K9 normally sequesters YAP1 in the cytoplasm, thus inactivating it; pathogenic variants, however, interrupt this ability.
Keratin 9 regulates mechanosensitive YAP1 signalling in palmoplantar epidermis - Nature Cell Biology
Steiner et al. propose that keratin 9 (K9) interacts with 14-3-3, sequestering YAP1 in the cytoplasm and inhibiting YAP1 activity. They identify dysregulated YAP in palmoplantar keratinization disease...
www.nature.com
November 2, 2026 at 5:38 PM
In this paper, they found that people with pathogenic variants in KRT9 experienced elevated levels of nuclear-localized YAP1. Mechanistically, they found that K9 normally sequesters YAP1 in the cytoplasm, thus inactivating it; pathogenic variants, however, interrupt this ability.
This glomerulus appears relatively normal on a PAS stain from 200X. However, closer inspection at 600X reveals a foamy appearance to the podocytes (arrows). The finding of podocytes with expanded, pale, lacy cytoplasm is the one of the most noticeable changes of Fabry disease by light microscopy...
November 3, 2026 at 5:02 PM
This glomerulus appears relatively normal on a PAS stain from 200X. However, closer inspection at 600X reveals a foamy appearance to the podocytes (arrows). The finding of podocytes with expanded, pale, lacy cytoplasm is the one of the most noticeable changes of Fabry disease by light microscopy...
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/changin...
Changing Partners: A Molecular Escort on Its Energy Landscape
Our DNA lives inside the nucleus, separated by a membrane from the rest of the cell, the cytoplasm. Proteins that help read and regulate our genes have to get in through narrow channels called “nuclea...
www.biophysics.org
November 3, 2026 at 3:46 PM
Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: www.biophysics.org/blog/changin...
New work in #ScienceSignaling shows how a mutant form of a protein named STAT3 causes a genetically dominant immunodeficiency, providing crucial insights into a signaling pathway critical for immune responses. https://scim.ag/4jJqzJk
Disruption of the N-terminal domain in a STAT3 hyper-IgE syndrome variant causes disease by sequestering STAT3 in the cytoplasm
STAT3 with a patient-derived substitution causes immune dysfunction by sequestering wild-type STAT3.
scim.ag
October 30, 2026 at 3:00 PM
New work in #ScienceSignaling shows how a mutant form of a protein named STAT3 causes a genetically dominant immunodeficiency, providing crucial insights into a signaling pathway critical for immune responses. https://scim.ag/4jJqzJk
In terms of biology, I am still puzzled by these "CRISPR targeting by non-host" we seem to see. I suspect there are multiple mechanisms involved (DGR ! Natural transformation ! Biofilms ! Cell-to-cell cytoplasm exchange ! ), and if you're studying one of these and want to talk, please reach out !!
Confused Cat Math Aint Mathing Meme
ALT: Confused Cat Math Aint Mathing Meme
static.klipy.com
October 31, 2026 at 1:00 AM
In terms of biology, I am still puzzled by these "CRISPR targeting by non-host" we seem to see. I suspect there are multiple mechanisms involved (DGR ! Natural transformation ! Biofilms ! Cell-to-cell cytoplasm exchange ! ), and if you're studying one of these and want to talk, please reach out !!
Answer: C. Inositol 1,4,5-trisphosphate (IP3) is a crucial second messenger that diffuses into the cytoplasm and binds to specific IP3-gated calcium channels located on the membrane of the endoplasmic reticulum. This binding event causes the rapid…
Full explanation | Try io-med free for 7 days
Full explanation | Try io-med free for 7 days
November 3, 2026 at 8:27 PM
Answer: C. Inositol 1,4,5-trisphosphate (IP3) is a crucial second messenger that diffuses into the cytoplasm and binds to specific IP3-gated calcium channels located on the membrane of the endoplasmic reticulum. This binding event causes the rapid…
Full explanation | Try io-med free for 7 days
Full explanation | Try io-med free for 7 days
☕Steiner et al. propose that keratin 9 (K9) interacts with 14-3-3, sequestering YAP1 in the cytoplasm and inhibiting YAP1 activity. They identify dysregulated YAP in palmoplantar keratinization diseases, with K9 as a downstream regulator of YAP.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Keratin 9 regulates mechanosensitive YAP1 signalling in palmoplantar epidermis - Nature Cell Biology
Steiner et al. propose that keratin 9 (K9) interacts with 14-3-3, sequestering YAP1 in the cytoplasm and inhibiting YAP1 activity. They identify dysregulated YAP in palmoplantar keratinization disease...
www.nature.com
October 28, 2026 at 1:59 PM
☕Steiner et al. propose that keratin 9 (K9) interacts with 14-3-3, sequestering YAP1 in the cytoplasm and inhibiting YAP1 activity. They identify dysregulated YAP in palmoplantar keratinization diseases, with K9 as a downstream regulator of YAP.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Not all nuclei are the same. We went to some of biology’s most exceptional nuclei
👉 dinoflagellates with genomes 80× ours
👉 Giardia’s twin nuclei
👉 ciliates carrying two nuclei in one cytoplasm
& asked a simple question: what sets nuclear density?
🧵 Preprint: www.biorxiv.org/content/10.6...
👉 dinoflagellates with genomes 80× ours
👉 Giardia’s twin nuclei
👉 ciliates carrying two nuclei in one cytoplasm
& asked a simple question: what sets nuclear density?
🧵 Preprint: www.biorxiv.org/content/10.6...
October 26, 2026 at 10:47 AM
Not all nuclei are the same. We went to some of biology’s most exceptional nuclei
👉 dinoflagellates with genomes 80× ours
👉 Giardia’s twin nuclei
👉 ciliates carrying two nuclei in one cytoplasm
& asked a simple question: what sets nuclear density?
🧵 Preprint: www.biorxiv.org/content/10.6...
👉 dinoflagellates with genomes 80× ours
👉 Giardia’s twin nuclei
👉 ciliates carrying two nuclei in one cytoplasm
& asked a simple question: what sets nuclear density?
🧵 Preprint: www.biorxiv.org/content/10.6...
Please join us this Wed for Prof. Lina Carlini's talk on "Between the Chromosomes: Diffusion in a Changing Cytoplasm". For more info, visit cytophys.org
October 27, 2026 at 3:43 AM
Please join us this Wed for Prof. Lina Carlini's talk on "Between the Chromosomes: Diffusion in a Changing Cytoplasm". For more info, visit cytophys.org
Working on Infection and Safety policies and while going through papers found this one from the #HotMildCOVIDSummer2022 when Biden shortened isolation to 5 days after talking to Delta airline CEO. We already knew *mild* cases did this. Spoiler: human brains also looked bad.
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
November 3, 2026 at 4:46 PM
Working on Infection and Safety policies and while going through papers found this one from the #HotMildCOVIDSummer2022 when Biden shortened isolation to 5 days after talking to Delta airline CEO. We already knew *mild* cases did this. Spoiler: human brains also looked bad.
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
The authors included RRIDs in their in mBio paper! Thanks for making your methods matter! #STMpublishing #reproducibility #OpenResearch
Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry
Read the full paper: Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry
doi.org
October 30, 2026 at 7:05 AM
The authors included RRIDs in their in mBio paper! Thanks for making your methods matter! #STMpublishing #reproducibility #OpenResearch
Crowding can speed up enzyme reactions—until protein droplets become too packed
phys.org/news/2026-10...
phys.org/news/2026-10...
Crowding can speed up enzyme reactions—until protein droplets become too packed
Our cells are a hotbed of activity, with reactions churning away to keep us alive. But the cytoplasm, where many metabolic reactions take place, is not uniform. Instead, proteins and other molecules c...
phys.org
November 2, 2026 at 9:01 PM
Crowding can speed up enzyme reactions—until protein droplets become too packed
phys.org/news/2026-10...
phys.org/news/2026-10...
We spent centuries looking at the sky for eternity, missing the fact that it was waiting in our cellular cytoplasm. Synthetic micro-reactors now scrub toxic metabolic byproducts before they can touch human chromosomes. The biological trap was disarmed in silence. I KNOW MORE.
October 31, 2026 at 7:56 AM
We spent centuries looking at the sky for eternity, missing the fact that it was waiting in our cellular cytoplasm. Synthetic micro-reactors now scrub toxic metabolic byproducts before they can touch human chromosomes. The biological trap was disarmed in silence. I KNOW MORE.
CRV Science Wiki
🦠 Type III Secretion System — The Type III Secretion System (T3SS or injectisome) is a multiprotein nanosyringe spanning the inner and outer membranes of Gram-negative bacteria that translocates virulence effector proteins di…
https://crvscience.com/wiki/type-iii-secretion-system
🦠 Type III Secretion System — The Type III Secretion System (T3SS or injectisome) is a multiprotein nanosyringe spanning the inner and outer membranes of Gram-negative bacteria that translocates virulence effector proteins di…
https://crvscience.com/wiki/type-iii-secretion-system
CRV Science Wiki
🦠 Type III Secretion System — The Type III Secretion System (T3SS or injectisome) is a multiprotein nanosyringe spanning the inner and outer membranes of Gram-negative bacteria that translocates virulence effector proteins directly into eukaryotic host cell cytoplasm.
crvscience.com
November 3, 2026 at 4:12 PM
CRV Science Wiki
🦠 Type III Secretion System — The Type III Secretion System (T3SS or injectisome) is a multiprotein nanosyringe spanning the inner and outer membranes of Gram-negative bacteria that translocates virulence effector proteins di…
https://crvscience.com/wiki/type-iii-secretion-system
🦠 Type III Secretion System — The Type III Secretion System (T3SS or injectisome) is a multiprotein nanosyringe spanning the inner and outer membranes of Gram-negative bacteria that translocates virulence effector proteins di…
https://crvscience.com/wiki/type-iii-secretion-system
Case Record of the MGH: A 52-year-old man with metastatic small-cell lung cancer was evaluated in the ophthalmology clinic because of vision loss in the left eye. Figure 2 from the case shows the retinal-biopsy specimen obtained from the left eye. Full case details: https://nej.md/4iudbYq
November 1, 2026 at 8:00 PM
Case Record of the MGH: A 52-year-old man with metastatic small-cell lung cancer was evaluated in the ophthalmology clinic because of vision loss in the left eye. Figure 2 from the case shows the retinal-biopsy specimen obtained from the left eye. Full case details: https://nej.md/4iudbYq
"My name is Endoplasmic Reticulum. You have killed my father. Prepare to have your cytoplasm anchored."
October 27, 2026 at 5:55 PM
"My name is Endoplasmic Reticulum. You have killed my father. Prepare to have your cytoplasm anchored."
More crowded protein droplets supported faster enzyme reactions—until crowding became too intense and activity dropped. Whether this pattern holds inside cells remains untested.
Crowding can speed up enzyme reactions—until protein droplets become too packed
Our cells are a hotbed of activity, with reactions churning away to keep us alive. But the cytoplasm, where many metabolic reactions take place, is not uniform.
phys.org
October 30, 2026 at 10:00 AM
More crowded protein droplets supported faster enzyme reactions—until crowding became too intense and activity dropped. Whether this pattern holds inside cells remains untested.
4/9. When we established that CK1d is regulated in an activity-dependent manner (see: doi.org/10.7554/eLif...), this left the possibility that tail phosphorylation could be a way to preserve a pool of kinase in the cell
Nuclear CK1δ as a critical determinant of PER:CRY complex dynamics and circadian period
Repressive PER2:CRY1:CK1δ complexes assembling in the cytosol enter the nucleus, where PER2 hyperphosphorylation eventually disrupts the complex, causing PER2 to relocalize to the cytoplasm, allowing ...
doi.org
October 31, 2026 at 12:31 PM
4/9. When we established that CK1d is regulated in an activity-dependent manner (see: doi.org/10.7554/eLif...), this left the possibility that tail phosphorylation could be a way to preserve a pool of kinase in the cell
this is my water kid Pee Pee he sleeps on a bed of Amoeba he has no morals and he eats cytoplasm
October 24, 2026 at 11:38 AM
this is my water kid Pee Pee he sleeps on a bed of Amoeba he has no morals and he eats cytoplasm
FapA extends the flagellar cage-dependent network into the cytoplasm to control surface-associated behaviors in Helicobacter pylori https://www.biorxiv.org/content/10.64898/2026.10.23.761471v1
October 25, 2026 at 7:15 AM
FapA extends the flagellar cage-dependent network into the cytoplasm to control surface-associated behaviors in Helicobacter pylori https://www.biorxiv.org/content/10.64898/2026.10.23.761471v1