This is fascinating, but also terrible news regarding antimicrobial resistance in multidrug-resistant Gram-positives
'Emergence of transferable daptomycin resistance in Gram-positive bacteria'
www.nature.com/articles/s44...
'Emergence of transferable daptomycin resistance in Gram-positive bacteria'
www.nature.com/articles/s44...
Emergence of transferable daptomycin resistance in Gram-positive bacteria - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Emergence of transferable daptomycin resistance in Gram-positive bacteria
www.nature.com
April 29, 2025 at 9:53 AM
This is fascinating, but also terrible news regarding antimicrobial resistance in multidrug-resistant Gram-positives
'Emergence of transferable daptomycin resistance in Gram-positive bacteria'
www.nature.com/articles/s44...
'Emergence of transferable daptomycin resistance in Gram-positive bacteria'
www.nature.com/articles/s44...
So happy our pre-print on daptomycin mechanism of action is now out! Here, we present three main findings: i) daptomycin does not form large membrane pores in either B. subtilis or S. aureus, (1/3)
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action https://www.biorxiv.org/content/10.1101/2024.12.20.629673v1
December 21, 2024 at 3:45 PM
So happy our pre-print on daptomycin mechanism of action is now out! Here, we present three main findings: i) daptomycin does not form large membrane pores in either B. subtilis or S. aureus, (1/3)
Research shows: Rifaximin prophylaxis drives resistance to daptomycin, an unrelated, last-resort antibiotic
Rifaximin is used for hepatic encephalopathy in liver patients at high risk for infections, including VRE treated with daptomycin. The antibiotic was thought to pose a low resistance risk
Rifaximin is used for hepatic encephalopathy in liver patients at high risk for infections, including VRE treated with daptomycin. The antibiotic was thought to pose a low resistance risk
Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin - Nature
Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.
www.nature.com
March 5, 2025 at 11:33 AM
Research shows: Rifaximin prophylaxis drives resistance to daptomycin, an unrelated, last-resort antibiotic
Rifaximin is used for hepatic encephalopathy in liver patients at high risk for infections, including VRE treated with daptomycin. The antibiotic was thought to pose a low resistance risk
Rifaximin is used for hepatic encephalopathy in liver patients at high risk for infections, including VRE treated with daptomycin. The antibiotic was thought to pose a low resistance risk
Super excited to share the final version of our story on how Enterococcus faecalis remodels membrane lipids to protect itself from daptomycin! 🥳
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin | PNAS
Daptomycin is a last resort antibiotic used to treat vancomycin-resistant enterococcal
infections, but daptomycin resistance (DAPR) arises quickly ...
www.pnas.org
April 24, 2026 at 5:29 AM
Super excited to share the final version of our story on how Enterococcus faecalis remodels membrane lipids to protect itself from daptomycin! 🥳
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
November 24, 2025 at 8:20 PM
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action https://www.biorxiv.org/content/10.1101/2024.12.20.629673v1
December 21, 2024 at 3:17 PM
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action https://www.biorxiv.org/content/10.1101/2024.12.20.629673v1
spending my youth blabbing bout daptomycin mics
July 10, 2026 at 3:28 PM
spending my youth blabbing bout daptomycin mics
This is amazing and important work by Glen Carter and colleagues at the University of Melbourne
'Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin in Enterococcus'
www.nature.com/articles/s41...
'Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin in Enterococcus'
www.nature.com/articles/s41...
Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin - Nature
Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.
www.nature.com
October 24, 2024 at 7:09 AM
This is amazing and important work by Glen Carter and colleagues at the University of Melbourne
'Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin in Enterococcus'
www.nature.com/articles/s41...
'Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin in Enterococcus'
www.nature.com/articles/s41...
Ceftaroline, sulopenem, daptomycin, colistin, aztreonam, linezolid
Spotify wrapped, but for antibiotics. What’s yours?
December 9, 2024 at 1:48 AM
Ceftaroline, sulopenem, daptomycin, colistin, aztreonam, linezolid
Interesting phase II trial of adding Daptomycin to Ceftriaxone for pneumococcal meningitis in France 🇫🇷
Needs more study but encouraging signal for a reduction in disability
#escmidglobal2026
Needs more study but encouraging signal for a reduction in disability
#escmidglobal2026
April 18, 2026 at 1:17 PM
Interesting phase II trial of adding Daptomycin to Ceftriaxone for pneumococcal meningitis in France 🇫🇷
Needs more study but encouraging signal for a reduction in disability
#escmidglobal2026
Needs more study but encouraging signal for a reduction in disability
#escmidglobal2026
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 8:27 PM
Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.
Just left the ID specialist. Aiming to be off the Daptomycin on June 12. Praying everything goes smoothly here on out.
May 6, 2025 at 6:22 PM
Just left the ID specialist. Aiming to be off the Daptomycin on June 12. Praying everything goes smoothly here on out.
en.wikipedia.org/wiki/Daptomy...
LRS: daptomycin is one of the antibiotics used as a heavy hitter for gram-positive germs resistant to other stuff, think MRSA. It's got shitty side effects which are all better than dying.
Seeing it is a big "oh fuck nosocomial infections are here" signal.
LRS: daptomycin is one of the antibiotics used as a heavy hitter for gram-positive germs resistant to other stuff, think MRSA. It's got shitty side effects which are all better than dying.
Seeing it is a big "oh fuck nosocomial infections are here" signal.
Daptomycin - Wikipedia
en.wikipedia.org
January 16, 2026 at 3:15 PM
en.wikipedia.org/wiki/Daptomy...
LRS: daptomycin is one of the antibiotics used as a heavy hitter for gram-positive germs resistant to other stuff, think MRSA. It's got shitty side effects which are all better than dying.
Seeing it is a big "oh fuck nosocomial infections are here" signal.
LRS: daptomycin is one of the antibiotics used as a heavy hitter for gram-positive germs resistant to other stuff, think MRSA. It's got shitty side effects which are all better than dying.
Seeing it is a big "oh fuck nosocomial infections are here" signal.
Thanks for following!
Gidari A, et al. Daptomycin eosinophilic pneumonia, a systematic review of the literature and case series. Infection (2024). doi.org/10.1007/s150...
#emimcc #pulmsky #cccsky #foamed #foamcc #pharmsky #amssky #idsky
Gidari A, et al. Daptomycin eosinophilic pneumonia, a systematic review of the literature and case series. Infection (2024). doi.org/10.1007/s150...
#emimcc #pulmsky #cccsky #foamed #foamcc #pharmsky #amssky #idsky
Daptomycin eosinophilic pneumonia, a systematic review of the literature and case series - Infection
Purpose Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare yet severe adverse event that requires rapid recognition and management. Diagnosing a definite case is challenging and involves meeti...
doi.org
November 30, 2024 at 8:38 PM
11-year on Enterococcus in Riyadh, Saudi Arabia hospitals:
• High-level gentamicin resistance declined, susceptibility to linezolid, daptomycin & tigecycline stayed high (>95%).
• VRE rates & MDR remained unchanged, with E. faecium linked to higher mortality.
#AMR
share.google/H9h2gLRqJHNB...
• High-level gentamicin resistance declined, susceptibility to linezolid, daptomycin & tigecycline stayed high (>95%).
• VRE rates & MDR remained unchanged, with E. faecium linked to higher mortality.
#AMR
share.google/H9h2gLRqJHNB...
share.google
September 27, 2026 at 5:58 AM
11-year on Enterococcus in Riyadh, Saudi Arabia hospitals:
• High-level gentamicin resistance declined, susceptibility to linezolid, daptomycin & tigecycline stayed high (>95%).
• VRE rates & MDR remained unchanged, with E. faecium linked to higher mortality.
#AMR
share.google/H9h2gLRqJHNB...
• High-level gentamicin resistance declined, susceptibility to linezolid, daptomycin & tigecycline stayed high (>95%).
• VRE rates & MDR remained unchanged, with E. faecium linked to higher mortality.
#AMR
share.google/H9h2gLRqJHNB...
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
November 17, 2025 at 6:17 PM
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1
Resistance to daptomycin in near-untreatable superbug caused by a different antibiotic, study finds
Resistance to daptomycin in near-untreatable superbug caused by a different antibiotic, study finds
‘Surprising’ finding by Australian-led study is first recorded instance of an antibiotic causing resistance to one in a different class
www.theguardian.com
October 23, 2024 at 7:09 PM
Resistance to daptomycin in near-untreatable superbug caused by a different antibiotic, study finds
Development of off-target antibiotic resistance is always a worry.
Rifaximin is used as prophylaxis for hepatic encephalopathy in patients with cirrhosis.
This study indicates rifaximin may select out resistance to unrelated daptomycin
#IDSky #MicroSky #AMR 🩺🦠
www.nature.com/artic...
1/2
Rifaximin is used as prophylaxis for hepatic encephalopathy in patients with cirrhosis.
This study indicates rifaximin may select out resistance to unrelated daptomycin
#IDSky #MicroSky #AMR 🩺🦠
www.nature.com/artic...
1/2
Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin
Nature - Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.
www.nature.com
October 24, 2024 at 7:16 AM
Development of off-target antibiotic resistance is always a worry.
Rifaximin is used as prophylaxis for hepatic encephalopathy in patients with cirrhosis.
This study indicates rifaximin may select out resistance to unrelated daptomycin
#IDSky #MicroSky #AMR 🩺🦠
www.nature.com/artic...
1/2
Rifaximin is used as prophylaxis for hepatic encephalopathy in patients with cirrhosis.
This study indicates rifaximin may select out resistance to unrelated daptomycin
#IDSky #MicroSky #AMR 🩺🦠
www.nature.com/artic...
1/2
@bryanpwhite.bsky.social et al: In a cohort (n=127) of OPAT patients on daptomycin 7.4 mg/kg for an average of 37 days, the rate of CK elevation was 11.8% at a median of 13 days (IQR 9-16) supporting weekly lab monitoring on daptomycin for OPAT. doi.org/10.1017/ash....
Incidence and risk factors for musculoskeletal adverse effects associated with daptomycin in patients receiving outpatient parenteral antimicrobial therapy | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core
Incidence and risk factors for musculoskeletal adverse effects associated with daptomycin in patients receiving outpatient parenteral antimicrobial therapy - Volume 5 Issue 1
doi.org
July 31, 2025 at 11:29 AM
@bryanpwhite.bsky.social et al: In a cohort (n=127) of OPAT patients on daptomycin 7.4 mg/kg for an average of 37 days, the rate of CK elevation was 11.8% at a median of 13 days (IQR 9-16) supporting weekly lab monitoring on daptomycin for OPAT. doi.org/10.1017/ash....
I've used it, but don't love it. Viridans group has some data on in vivo resistance development, although in animal models pmc.ncbi.nlm.nih.gov/articles/PMC... #IDSky
Early In Vitro and In Vivo Development of High-Level Daptomycin Resistance Is Common in Mitis Group Streptococci after Exposure to Daptomycin
The development of high-level daptomycin resistance (HLDR; MIC of ≥256 mg/liter) after exposure to daptomycin has recently been reported in viridans group streptococcus (VGS) isolates. Our study objec...
pmc.ncbi.nlm.nih.gov
December 19, 2024 at 11:42 PM
I've used it, but don't love it. Viridans group has some data on in vivo resistance development, although in animal models pmc.ncbi.nlm.nih.gov/articles/PMC... #IDSky
When the patient is on daptomycin and ceftaroline but still gets peri-op cefazolin. #IDsky
a man wearing sunglasses and a white t-shirt is holding something in his hands .
Alt: salt bae gif (guy in white shirt and sunglasses sprinkles salt in a very showy way)
media.tenor.com
March 14, 2026 at 12:41 AM
When the patient is on daptomycin and ceftaroline but still gets peri-op cefazolin. #IDsky
Latest from the lab, driven by Lizzie Ledger. Crossover in antibiotic resistance activity between oxacilin and daptomycin. …. All roads may lead to Rome in some places but for S. aureus they all lead to Agr activity!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Expression of mecA reduces the daptomycin susceptibility of Staphylococcus aureus
Staphylococcus aureus is a leading cause of bacteraemia and infections caused by methicillin-resistant strains (MRSA) are especially challenging to treat. MRSA strains are resistant to front-line beta...
www.biorxiv.org
February 12, 2025 at 2:12 PM
Latest from the lab, driven by Lizzie Ledger. Crossover in antibiotic resistance activity between oxacilin and daptomycin. …. All roads may lead to Rome in some places but for S. aureus they all lead to Agr activity!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Is there a future in which daptomycin replaces vancomycin for empiric meningitis coverage for resistant Strep pneumo?
#IDSky
#IDSky
Interesting phase II trial of adding Daptomycin to Ceftriaxone for pneumococcal meningitis in France 🇫🇷
Needs more study but encouraging signal for a reduction in disability
#escmidglobal2026
Needs more study but encouraging signal for a reduction in disability
#escmidglobal2026
April 18, 2026 at 11:32 PM
Is there a future in which daptomycin replaces vancomycin for empiric meningitis coverage for resistant Strep pneumo?
#IDSky
#IDSky
Emergence of dalbavancin, vancomycin, and daptomycin cross-resistance in MRSA during long-term LVAD suppression with vancomycin followed by dalbavancin: genomic insights and synergy with cefadroxil
✅ Just Accepted
🔗 https://bit.ly/4azpqPJ
✅ Just Accepted
🔗 https://bit.ly/4azpqPJ
February 24, 2026 at 9:55 PM
Emergence of dalbavancin, vancomycin, and daptomycin cross-resistance in MRSA during long-term LVAD suppression with vancomycin followed by dalbavancin: genomic insights and synergy with cefadroxil
✅ Just Accepted
🔗 https://bit.ly/4azpqPJ
✅ Just Accepted
🔗 https://bit.ly/4azpqPJ