#dentategyrus
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riannejar.bsky.social
Adult brains do make new neurons [via @sciam.bsky.social] 🧪⚗️⚕️🧠💭

"if adult neurogenesis happened anywhere, it was in the #hippocampus, a deep-brain structure known for its role in memory processing and storage."

www.scientificamerican.com/article/proo...

#adult #neurogenesis #brain #DentateGyrus
Proof That Adult Brains Make New Neurons Settles Scientific Controversy
Adult brains grow new neurons, and scientists have finally pinpointed where they come from
www.scientificamerican.com
July 7, 2025 at 3:47 PM
chemcenterbio.bsky.social
Reversing Brain Damage: 48% Newborn Neurons in Prefrontal Cortex & Dentate Gyrus!! #J147 #mitochondria #ATPsynthase #dentategyrus #cellularbioenergetics #neurogenesis #brainenergy #freeradicals #antiaging #longevityresearch #neurobiology #biohacking
September 29, 2026 at 3:48 PM
philoneurosci.bsky.social
#Dentategyrus #interneurons modulate winner-take-all network #dynamics in freely #behaving #mice: Neuron www.cell.com/neuron/fullt...
Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice
Hainmueller, Heynold, et al. studied the activity and synaptic interactions of different excitatory and inhibitory neuron types in the dentate gyrus of freely behaving mice. Bidirectional optogenetic ...
www.cell.com
April 30, 2026 at 3:19 PM
aixa-v-morales.bsky.social
7️⃣To sum up, our work shows that Sox5 is crucial to balance shallow and deep #Quiescence in NSCs during the first postnatal weeks of #DentateGyrus development. This balance ⚖️ is crucial for long-lasting #AdultNeurogenesis✨🔬
August 7, 2025 at 3:21 PM
aixa-v-morales.bsky.social
1️⃣Here we show that Sox5 is crucial for developmental NSCs to enter #Quiescence and for long-life maintenance of the adult stem niche in the #DentateGyrus of the #Hippocampus . Do you want to learn more?
journals.plos.org/plosbiology/...
@institutocajal.bsky.social @csic.es @csicdivulga.bsky.social
August 7, 2025 at 3:21 PM
aixa-v-morales.bsky.social
3️⃣When Sox5 is lost, there is an accumulation of shallow quiescent NSCs at P14 more prone to activation. This causes a neurogenic burst in the adult #DentateGyrus at P30 and ultimately results in a premature depletion of the NSC pool. Essentially, too much too soon leads to not enough later !!
August 7, 2025 at 3:21 PM
haoyin.bsky.social
Regionalized loss (CA1/2/3/4 #DentateGyrus) of Hippocampal #Pericytes in👤#Stroke #VascularDementia #AlzheimersDisease

ColIV IHC + Abluminal soma to identify pericytes on 10-μm section

#ActaNeuropatholCommun 2024
actaneurocomms.biomedcentral.com/articles/10....
February 21, 2024 at 12:39 PM
stemcellreports.bsky.social
Researchers identify 129 genes enriched in murine NPCs, including 15 genes linked to novel neurological conditions, highlighting NPC molecular mechanisms in brain development and disease. #dentategyrus ow.ly/aIUq50WJMHi

@bcmhouston.bsky.social @isscr.org
August 27, 2025 at 8:52 PM
plosbiology.org
How do #memory systems balance sensitivity vs stability? This study shows that #DentateGyrus inhibition regulates this trade-off. Lower inhibition enhances discrimination but increases interference; higher inhibition stabilizes memories at the cost of sensitivity @plosbiology.org 🧪 plos.io/45wRCzk
Schematic representation of the memory load-dependent sensitivity-consistency trade-off. The figure illustrates the proposed relationship between discrimination performance and the balance between consistency and sensitivity as a function of hippocampal inhibitory tone. Three curves represent different levels of memory load: low load (light gray), medium load (gray), and high load (black). For each load, optimal discrimination occurs at a different point along the consistency–sensitivity axis, indicated by an arrow. As memory load increases, maximal discrimination decreases and the optimal operating point shifts toward a more consistent, inhibition-dominated state. The vertical dashed lines illustrate two experimental conditions. The orange line represents reduced inhibition, comparable to the PV-Gi condition, which enhances discrimination under low-load conditions but impairs discrimination when memory load is high. Conversely, the blue line represents increased inhibition, comparable to the PV-Gq condition, which favors consistency but reduces discrimination when fine sensitivity is required. Thus, as observed experimentally, disinhibition is predicted to have a stronger detrimental effect under high-load conditions, whereas its effect can be beneficial when memory load is low and increased sensitivity supports discrimination.
August 20, 2026 at 8:00 AM
plosbiology.org
How can #memory systems balance sensitivity vs stability? This study shows that #DentateGyrus inhibition regulates this trade-off. Lower inhibition enhances discrimination but increases interference; higher inhibition stabilizes memories at the cost of sensitivity @plosbiology.org 🧪 plos.io/45wRCzk
Schematic representation of the memory load-dependent sensitivity-consistency trade-off. The figure illustrates the proposed relationship between discrimination performance and the balance between consistency and sensitivity as a function of hippocampal inhibitory tone. Three curves represent different levels of memory load: low load (light gray), medium load (gray), and high load (black). For each load, optimal discrimination occurs at a different point along the consistency–sensitivity axis, indicated by an arrow. As memory load increases, maximal discrimination decreases and the optimal operating point shifts toward a more consistent, inhibition-dominated state. The vertical dashed lines illustrate two experimental conditions. The orange line represents reduced inhibition, comparable to the PV-Gi condition, which enhances discrimination under low-load conditions but impairs discrimination when memory load is high. Conversely, the blue line represents increased inhibition, comparable to the PV-Gq condition, which favors consistency but reduces discrimination when fine sensitivity is required. Thus, as observed experimentally, disinhibition is predicted to have a stronger detrimental effect under high-load conditions, whereas its effect can be beneficial when memory load is low and increased sensitivity supports discrimination.
August 19, 2026 at 4:30 PM
plosbiology.org
How can #memory systems balance sensitivity vs stability? This study shows that #DentateGyrus inhibition regulates this trade-off. Lower inhibition enhances discrimination but increases interference; higher inhibition stabilizes memories at the cost of sensitivity @plosbiology.org 🧪 plos.io/45wRCzk
Schematic representation of the memory load-dependent sensitivity-consistency trade-off. The figure illustrates the proposed relationship between discrimination performance and the balance between consistency and sensitivity as a function of hippocampal inhibitory tone. Three curves represent different levels of memory load: low load (light gray), medium load (gray), and high load (black). For each load, optimal discrimination occurs at a different point along the consistency–sensitivity axis, indicated by an arrow. As memory load increases, maximal discrimination decreases and the optimal operating point shifts toward a more consistent, inhibition-dominated state. The vertical dashed lines illustrate two experimental conditions. The orange line represents reduced inhibition, comparable to the PV-Gi condition, which enhances discrimination under low-load conditions but impairs discrimination when memory load is high. Conversely, the blue line represents increased inhibition, comparable to the PV-Gq condition, which favors consistency but reduces discrimination when fine sensitivity is required. Thus, as observed experimentally, disinhibition is predicted to have a stronger detrimental effect under high-load conditions, whereas its effect can be beneficial when memory load is low and increased sensitivity supports discrimination.
August 21, 2026 at 1:01 PM
eisch.bsky.social
🧪🧠🚼Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety www.cell.com/cell-reports... #DentateGyrus
Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety
Nabila et al. show that the transcriptomic impact of gestational adversity is variable across hippocampal neurons and that the most affected neurons are activated during stress. These neurons exhibit ...
www.cell.com
September 26, 2025 at 11:40 AM
philoneurosci.bsky.social
The #dentategyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental #representations
doi.org/10.1038/s415...
The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations - Nature Neuroscience
This study reveals how the dentate gyrus gradually learns to integrate olfactory and spatial signals from the entorhinal cortex, transforming them into sparse and highly specific representations that ...
doi.org
April 2, 2026 at 7:26 PM
philoneurosci.bsky.social
Interesting, but I feel like this needs to be replicated.

Identification of an #engram #ensemble mediating #memory #forgetting in the #dentategyrus: Neuron www.cell.com/neuron/fullt...
Identification of an engram ensemble mediating memory forgetting in the dentate gyrus
Hu et al. show that the dentate gyrus engram comprises two neuronal ensembles: one supports remembering, and the other promotes forgetting. By shifting the balance between these ensembles via Rac1 sig...
www.cell.com
February 3, 2026 at 5:13 PM