just realized that my web domains are older than anyone on the team i manage
November 3, 2026 at 6:57 PM
just realized that my web domains are older than anyone on the team i manage
Great news! Our preprint describing how we designed synthetic activation domains went live! www.biorxiv.org/content/10.6... Combining Markov Chains to generate sequences and neural networks to score them creates very strong activation domains. 90% worked. Compliments @chenomics.bsky.social nicely
Machine learning guided design of strong transcriptional activation domains
Artificial intelligence has accelerated the design of structured proteins, but it remains difficult to design functional intrinsically disordered proteins because of weak structural constraints and po...
www.biorxiv.org
November 6, 2026 at 4:06 PM
Great news! Our preprint describing how we designed synthetic activation domains went live! www.biorxiv.org/content/10.6... Combining Markov Chains to generate sequences and neural networks to score them creates very strong activation domains. 90% worked. Compliments @chenomics.bsky.social nicely
Has anyone or Bluesky itself made a startup kit that all us engaged citizens can bring to our local governments to get them set up with their accounts and domains #onhere? That seems like a @joshuajfriedman.com joint
November 5, 2026 at 4:18 PM
Has anyone or Bluesky itself made a startup kit that all us engaged citizens can bring to our local governments to get them set up with their accounts and domains #onhere? That seems like a @joshuajfriedman.com joint
i finally decided to figure how custom handle domains work
November 3, 2026 at 4:08 PM
i finally decided to figure how custom handle domains work
btw, why do I think Rust is beautiful? It has solved a series of very difficult problems that span a large set of domains really, really well. from the borrow checker to portability across platforms. not perfect, but really well. it is a tremendous work of science and engineering
That is such a deep insult to the mountains of hard technical work that your slop is built on. My mistake to have higher expectations from humanity, but come on
(Also, Rust is a very beautiful language)
(Also, Rust is a very beautiful language)
November 5, 2026 at 8:11 AM
btw, why do I think Rust is beautiful? It has solved a series of very difficult problems that span a large set of domains really, really well. from the borrow checker to portability across platforms. not perfect, but really well. it is a tremendous work of science and engineering
Bispecific antibodies (BsAbs) have two distinct binding domains that can bind to two antigens or two epitopes of the same antigen simultaneously. If you are interested in learning about them, you can read all this and more here:
• pmc.ncbi.nlm.nih.gov/articles/PMC...
• pmc.ncbi.nlm.nih.gov/articles/PMC...
November 6, 2026 at 11:15 PM
Bispecific antibodies (BsAbs) have two distinct binding domains that can bind to two antigens or two epitopes of the same antigen simultaneously. If you are interested in learning about them, you can read all this and more here:
• pmc.ncbi.nlm.nih.gov/articles/PMC...
• pmc.ncbi.nlm.nih.gov/articles/PMC...
Domains start with "ww."
November 4, 2026 at 1:49 AM
Domains start with "ww."
Guys, Gals, and Nonbinary Pals...say hello to your new and improved Grand Duchess of the Digital Domains~!
THE GRAND DUCHESS 3.0 MODEL DEBUT WEEKEND STARTS NOW!
www.twitch.tv/rowanveetee
altstream.online/rowanveetee
#vtuber #envtuber #vsky #VTubersWithDisabilities
THE GRAND DUCHESS 3.0 MODEL DEBUT WEEKEND STARTS NOW!
www.twitch.tv/rowanveetee
altstream.online/rowanveetee
#vtuber #envtuber #vsky #VTubersWithDisabilities
November 6, 2026 at 5:51 PM
Guys, Gals, and Nonbinary Pals...say hello to your new and improved Grand Duchess of the Digital Domains~!
THE GRAND DUCHESS 3.0 MODEL DEBUT WEEKEND STARTS NOW!
www.twitch.tv/rowanveetee
altstream.online/rowanveetee
#vtuber #envtuber #vsky #VTubersWithDisabilities
THE GRAND DUCHESS 3.0 MODEL DEBUT WEEKEND STARTS NOW!
www.twitch.tv/rowanveetee
altstream.online/rowanveetee
#vtuber #envtuber #vsky #VTubersWithDisabilities
kagi have a super fun public leaderboard where you can see what sites everyone wants to die. answer: pinterest
kagi.com/stats?stat=i...
kagi.com/stats?stat=i...
November 6, 2026 at 2:35 PM
kagi have a super fun public leaderboard where you can see what sites everyone wants to die. answer: pinterest
kagi.com/stats?stat=i...
kagi.com/stats?stat=i...
Statement from the Office of the Bretwalda.
To enrich the economy of Wülferhampton I will be easing legislation regarding online content.
@onlyWülferhampton.gov.Mercia domains available for a small fee will include
Onlypans.
Onlyspans.
Onlylambs. Big in Wales, I'm guessing
Onlytrams
Etc...
To enrich the economy of Wülferhampton I will be easing legislation regarding online content.
@onlyWülferhampton.gov.Mercia domains available for a small fee will include
Onlypans.
Onlyspans.
Onlylambs. Big in Wales, I'm guessing
Onlytrams
Etc...
November 6, 2026 at 6:42 PM
Statement from the Office of the Bretwalda.
To enrich the economy of Wülferhampton I will be easing legislation regarding online content.
@onlyWülferhampton.gov.Mercia domains available for a small fee will include
Onlypans.
Onlyspans.
Onlylambs. Big in Wales, I'm guessing
Onlytrams
Etc...
To enrich the economy of Wülferhampton I will be easing legislation regarding online content.
@onlyWülferhampton.gov.Mercia domains available for a small fee will include
Onlypans.
Onlyspans.
Onlylambs. Big in Wales, I'm guessing
Onlytrams
Etc...
Finnish Defence Minister Antti Häkkänen warns of Russia's threat to Europe on #EuropeToday. "Russia is ramping up its military in all domains. We have to be prepared."
Full interview: https://l.euronews.com/T6OC
Full interview: https://l.euronews.com/T6OC
November 6, 2026 at 8:09 AM
Finnish Defence Minister Antti Häkkänen warns of Russia's threat to Europe on #EuropeToday. "Russia is ramping up its military in all domains. We have to be prepared."
Full interview: https://l.euronews.com/T6OC
Full interview: https://l.euronews.com/T6OC
We are seeing reports of DNSSEC errors across multiple domains, rest assured our team is working on this and we are working on restoring the affected domains.
November 2, 2026 at 4:04 AM
We are seeing reports of DNSSEC errors across multiple domains, rest assured our team is working on this and we are working on restoring the affected domains.
we love our top level domains don't we folks
November 6, 2026 at 6:43 PM
we love our top level domains don't we folks
Have you found our WRETCHED DOMAINS?
Shit, lemme tell you what you're looking for:
Shit, lemme tell you what you're looking for:
November 2, 2026 at 8:32 PM
Have you found our WRETCHED DOMAINS?
Shit, lemme tell you what you're looking for:
Shit, lemme tell you what you're looking for:
Beget says a cyberattack destroyed VPS backups and cloud data.
Beget said attackers reached its management layer. Public data cited by Astra indicates the provider supports more than 700,000 active domains in Russia’s internet segment. 1/6
Beget said attackers reached its management layer. Public data cited by Astra indicates the provider supports more than 700,000 active domains in Russia’s internet segment. 1/6
November 4, 2026 at 7:01 AM
Beget says a cyberattack destroyed VPS backups and cloud data.
Beget said attackers reached its management layer. Public data cited by Astra indicates the provider supports more than 700,000 active domains in Russia’s internet segment. 1/6
Beget said attackers reached its management layer. Public data cited by Astra indicates the provider supports more than 700,000 active domains in Russia’s internet segment. 1/6
More than one million domains are now hosted by Infomaniak. 🎉
One million people have made that choice. And if you haven't yet, now's the time to join us 👉 https://www.infomaniak.com/gtl/domains
One million people have made that choice. And if you haven't yet, now's the time to join us 👉 https://www.infomaniak.com/gtl/domains
November 2, 2026 at 7:00 AM
More than one million domains are now hosted by Infomaniak. 🎉
One million people have made that choice. And if you haven't yet, now's the time to join us 👉 https://www.infomaniak.com/gtl/domains
One million people have made that choice. And if you haven't yet, now's the time to join us 👉 https://www.infomaniak.com/gtl/domains
someone had to have it, i suppose. four character .com domains are at a premium
November 6, 2026 at 7:28 PM
someone had to have it, i suppose. four character .com domains are at a premium
Thanks to @mbolotnikova.bsky.social for indulging my unpopular opinions on modular construction (which are that it's the indirect reward for getting the details of codes right across a wide range of domains, not something you achieve if you aspire to it specifically) www.vox.com/future-perfe...
Sweden builds houses and apartments like Lego sets. Why don’t we?
Zara Larsson isn’t the only Swedish export America should be obsessed with.
www.vox.com
November 6, 2026 at 3:19 PM
Thanks to @mbolotnikova.bsky.social for indulging my unpopular opinions on modular construction (which are that it's the indirect reward for getting the details of codes right across a wide range of domains, not something you achieve if you aspire to it specifically) www.vox.com/future-perfe...
Saw someone on Backloggd complain about Queen's Domains enemies by saying it "only" had 50+ truly unique enemies outside of bosses because of recolors (which isn't even accurate) but also what's a nice way to say the person in question very clearly knows nothing about game development.
November 5, 2026 at 12:09 AM
Saw someone on Backloggd complain about Queen's Domains enemies by saying it "only" had 50+ truly unique enemies outside of bosses because of recolors (which isn't even accurate) but also what's a nice way to say the person in question very clearly knows nothing about game development.
"what domains have you purchased that no one knows you own" would be like the next level facebook quiz spear-phishing engagement bait post, ngl
but also I really want to know 😭
but also I really want to know 😭
may I always have as much optimism for my ability to gsd as I do when I purchase domain names
November 6, 2026 at 10:27 PM
"what domains have you purchased that no one knows you own" would be like the next level facebook quiz spear-phishing engagement bait post, ngl
but also I really want to know 😭
but also I really want to know 😭
Under Republic Act No. 8371, or the Indigenous Peoples’ Rights Act, Indigenous communities have recognized rights over ancestral domains, including participation in projects that affect them.
Aeta people have spoken that Pax Silica will affect them. OUR INDIGENOUS PEOPLE.
Aeta people have spoken that Pax Silica will affect them. OUR INDIGENOUS PEOPLE.
November 6, 2026 at 6:30 PM
Under Republic Act No. 8371, or the Indigenous Peoples’ Rights Act, Indigenous communities have recognized rights over ancestral domains, including participation in projects that affect them.
Aeta people have spoken that Pax Silica will affect them. OUR INDIGENOUS PEOPLE.
Aeta people have spoken that Pax Silica will affect them. OUR INDIGENOUS PEOPLE.
is anyone doing like a diff-in-diff on anguila (the holder of dot ai domains) because i don't think we will get a cleaner policy experiment than "what if a govt got 17% more money for no reason, and thats completely extraneous to the local economy"
November 7, 2026 at 2:55 PM
is anyone doing like a diff-in-diff on anguila (the holder of dot ai domains) because i don't think we will get a cleaner policy experiment than "what if a govt got 17% more money for no reason, and thats completely extraneous to the local economy"
God i love owning domains i have no real use for
November 4, 2026 at 8:16 AM
God i love owning domains i have no real use for