Optic disc drusen (ODD) are calcified deposits located within the optic nerve head, anterior to the lamina cribrosa. Typically bilateral, ODD is present in approximately 2% of the general population. Patients with ODD have crowded optic discs and smaller cup-to-disc ratios compared to healthy individuals [1, 2]. Although ODD is often benign and discovered incidentally, they have been associated with visual field defects in up to 87% of cases [3, 4]. Most patients experience progressive and often unnoticed visual loss. Some ODD patients develop vascular complications, such as non-arteritic anterior ischaemic optic neuropathy (NAION), which can lead to significant vision loss [5, 6]. NAION is the most common form of ischaemic optic neuropathy in adults over the age of 50 [7]. NAION is associated with vascular risk factors such as diabetes mellitus, hypertension, and hyperlipidaemia [8]. ODD is considered an independent risk factor for NAION, as drusen-induced disc crowding may compromise vascular perfusion of the optic nerve head [9]. Existing literature suggests that patients who developed NAION following a diagnosis of ODD (ODD-AION) are less likely to have traditional vascular risk factors compared with patients with NAION alone [10]. Additionally, ODD-AION patients tend to be younger and demonstrate better long-term...

Pivotal trials of drugs used for systemic disease are generally designed around systemic outcomes, leaving potential ocular effects poorly characterized. Statins and age-related macular degeneration (AMD) illustrate this evidence gap. The accumulation of lipids in the Bruch membrane and drusen provides biological plausibility for targeting cholesterol pathways, but randomized evidence remains sparse. A Cochrane review identified only 2 randomized controlled trials involving 144 participants, one of which was a 30-participant study with 3 months of follow-up.

Ein Hitlergruß beim Stadtfest, Hetze gegen Musliminnen und ein Facebook-Kommentar über trauernde Drusen: Drei Prozesse in Salzburg, Feldkirch und Wien endeten mit bedingter Zusatzstrafe, unbedingter H...

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Die Drusen auf den Golanhöhen fühlten sich jahrzehntelang Syrien zugehörig - das scheint sich nun zu ändern.