Lol, I've gotten a handful of non-ABDLs to poop their diapers, but usually by then they're at least calling themselves ABDL curious, if not fledgling ABDLs
Soaking your Huggies is a gateway drug to loading them, which is a gateway drug to regression 🙂↕️
Soaking your Huggies is a gateway drug to loading them, which is a gateway drug to regression 🙂↕️
October 26, 2026 at 9:42 PM
Lol, I've gotten a handful of non-ABDLs to poop their diapers, but usually by then they're at least calling themselves ABDL curious, if not fledgling ABDLs
Soaking your Huggies is a gateway drug to loading them, which is a gateway drug to regression 🙂↕️
Soaking your Huggies is a gateway drug to loading them, which is a gateway drug to regression 🙂↕️
Brainomix's AI software flags potential responders to Remedy's stroke drug firstwordhealthtech.com/story/8317677
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firstwordhealthtech.com
October 29, 2026 at 12:07 AM
Brainomix's AI software flags potential responders to Remedy's stroke drug firstwordhealthtech.com/story/8317677
⭐ New #Editor's #Choice Article!
📖 Can microfluidic synthesis and SPAAC click chemistry improve the reproducibility, size control, and #drug-loading efficiency of poly(α-glutamic acid) #nanogels?
🔗 www.mdpi.com/1999-4923/17...
#Pharmaceutics #Microfluidic #Nanogels #SPAAC
·
📖 Can microfluidic synthesis and SPAAC click chemistry improve the reproducibility, size control, and #drug-loading efficiency of poly(α-glutamic acid) #nanogels?
🔗 www.mdpi.com/1999-4923/17...
#Pharmaceutics #Microfluidic #Nanogels #SPAAC
·
October 29, 2026 at 10:00 AM
⭐ New #Editor's #Choice Article!
📖 Can microfluidic synthesis and SPAAC click chemistry improve the reproducibility, size control, and #drug-loading efficiency of poly(α-glutamic acid) #nanogels?
🔗 www.mdpi.com/1999-4923/17...
#Pharmaceutics #Microfluidic #Nanogels #SPAAC
·
📖 Can microfluidic synthesis and SPAAC click chemistry improve the reproducibility, size control, and #drug-loading efficiency of poly(α-glutamic acid) #nanogels?
🔗 www.mdpi.com/1999-4923/17...
#Pharmaceutics #Microfluidic #Nanogels #SPAAC
·
Saw the Drug Mart security guy in the parking lot loading ammo in his gun. He took the ammo out twice then put it in his holster looked me right in the eye and said "Time to go to work."
Lol ok dipshit. Not to get all Mel Robbins, if someone wants to rob Drug Mart LET THEM!
Lol ok dipshit. Not to get all Mel Robbins, if someone wants to rob Drug Mart LET THEM!
October 24, 2026 at 1:40 PM
Saw the Drug Mart security guy in the parking lot loading ammo in his gun. He took the ammo out twice then put it in his holster looked me right in the eye and said "Time to go to work."
Lol ok dipshit. Not to get all Mel Robbins, if someone wants to rob Drug Mart LET THEM!
Lol ok dipshit. Not to get all Mel Robbins, if someone wants to rob Drug Mart LET THEM!
Doses land too low too, and that failure is quieter. Nusinersen was approved in 2016 for SMA at 12 mg. On Mar 30, 2026 the FDA approved a higher regimen of the same drug: two 50 mg loading doses, then 28 mg every four months. (7/8)
October 27, 2026 at 12:33 AM
Doses land too low too, and that failure is quieter. Nusinersen was approved in 2016 for SMA at 12 mg. On Mar 30, 2026 the FDA approved a higher regimen of the same drug: two 50 mg loading doses, then 28 mg every four months. (7/8)
Ultomiris blocks a protein called C5, part of the complement system, an early-response part of the immune system that can fire against the body's own tissue, and it's the first drug of that kind approved for IgAN. It's given as an IV infusion every 8 weeks after a loading dose.
October 26, 2026 at 6:32 PM
Ultomiris blocks a protein called C5, part of the complement system, an early-response part of the immune system that can fire against the body's own tissue, and it's the first drug of that kind approved for IgAN. It's given as an IV infusion every 8 weeks after a loading dose.
#3 Amlodipine (NORVASC)
Long-acting dihydropyridine CCB for hypertension and angina; ankle edema often limits it.
Mascot: (I) Am loading Nora’s vasc(ulature)
ballicules.com/drug/amlodip...
#top200drugs #pharmacystudent #pharmacology
Long-acting dihydropyridine CCB for hypertension and angina; ankle edema often limits it.
Mascot: (I) Am loading Nora’s vasc(ulature)
ballicules.com/drug/amlodip...
#top200drugs #pharmacystudent #pharmacology
October 24, 2026 at 2:09 PM
#3 Amlodipine (NORVASC)
Long-acting dihydropyridine CCB for hypertension and angina; ankle edema often limits it.
Mascot: (I) Am loading Nora’s vasc(ulature)
ballicules.com/drug/amlodip...
#top200drugs #pharmacystudent #pharmacology
Long-acting dihydropyridine CCB for hypertension and angina; ankle edema often limits it.
Mascot: (I) Am loading Nora’s vasc(ulature)
ballicules.com/drug/amlodip...
#top200drugs #pharmacystudent #pharmacology
FDA finalises playbook for prescription drug apps firstwordhealthtech.com/story/8247774
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firstwordhealthtech.com
October 21, 2026 at 1:12 AM
FDA finalises playbook for prescription drug apps firstwordhealthtech.com/story/8247774
Deep Origin and BioAge score early win in AI drug hunt #$BIOA firstwordhealthtech.com/story/8218894
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firstwordhealthtech.com
October 14, 2026 at 9:05 PM
Deep Origin and BioAge score early win in AI drug hunt #$BIOA firstwordhealthtech.com/story/8218894
Cognitive off loading is one hell of a drug
October 11, 2026 at 10:59 AM
Cognitive off loading is one hell of a drug
“FDA Says Safety Review Of Abortion Pill Will Continue Into Next Year” — Grade any article at RUSH Newstream https://beta.rushnewstream.com/article/106cc911bf557b78
FDA Says Safety Review Of Abortion Pill Will Continue Into Next Year
LOADING ERROR LOADING WASHINGTON (AP) — The Food and Drug Administration says its ongoing safety review of the nation’s main abortion pill will continue into next year, a timeline that was quickly con
beta.rushnewstream.com
October 9, 2026 at 7:32 PM
“FDA Says Safety Review Of Abortion Pill Will Continue Into Next Year” — Grade any article at RUSH Newstream https://beta.rushnewstream.com/article/106cc911bf557b78
WO2026201138A1 describes an EGFR-VHH/HER3 bispecific ADC with optimised drug loading. In SW620 xenografts, a single 10 mg/kg dose achieved 93.45% TGI, with regression in all six animals and partial responses in two at endpoint. Added EGFR-arm benefit over HER3-only ADCs remains unproven.
October 9, 2026 at 6:25 AM
WO2026201138A1 describes an EGFR-VHH/HER3 bispecific ADC with optimised drug loading. In SW620 xenografts, a single 10 mg/kg dose achieved 93.45% TGI, with regression in all six animals and partial responses in two at endpoint. Added EGFR-arm benefit over HER3-only ADCs remains unproven.
Nanoform has announced that its controlled expansion of supercritical solutions (CESS) technology has reached what it calls a cost leadership position compared with the current industry preferred technology, spray-dried amorphous solid dispersions (ASDs).
www.thepharmanavigator.com/news/nanofor...
www.thepharmanavigator.com/news/nanofor...
Nanoform Highlights CESS Benefits Versus Spray-Dried ASDs — The Pharma Navigator - Navigating The Key News Stories In Pharma
According to the company, its commercial-scale nanoparticle manufacturing technology could reduce production costs and solvent use while increasing drug loading.
www.thepharmanavigator.com
October 9, 2026 at 1:55 PM
Nanoform has announced that its controlled expansion of supercritical solutions (CESS) technology has reached what it calls a cost leadership position compared with the current industry preferred technology, spray-dried amorphous solid dispersions (ASDs).
www.thepharmanavigator.com/news/nanofor...
www.thepharmanavigator.com/news/nanofor...
🦠💊 Scientists uncovered new vulnerabilities in #drug-resistant #bacteria—including #energy production, defenses against #Phages and #toxin-delivery systems—that could provide targets for future treatments.
#AMR #Antimicrobial #Bacteria #Microsky via @sciencex.bsky.social
phys.org/news/2026-09...
#AMR #Antimicrobial #Bacteria #Microsky via @sciencex.bsky.social
phys.org/news/2026-09...
Energy production, virus defenses and toxin loading emerge as vulnerabilities in resistant bacteria
Antimicrobial resistance is one of the world's top public health threats. Often termed a silent pandemic, antimicrobial-resistant bacteria have caused millions of deaths annually. If left unchecked,…
phys.org
October 6, 2026 at 1:30 AM
🦠💊 Scientists uncovered new vulnerabilities in #drug-resistant #bacteria—including #energy production, defenses against #Phages and #toxin-delivery systems—that could provide targets for future treatments.
#AMR #Antimicrobial #Bacteria #Microsky via @sciencex.bsky.social
phys.org/news/2026-09...
#AMR #Antimicrobial #Bacteria #Microsky via @sciencex.bsky.social
phys.org/news/2026-09...
Local model railroad club show find: from the RailFair nvrra.com/content.aspx...
A USRA 0-8-0 switcher, brass, from Tenshodo. Also, two structure kits for cheap. The loco will be a fun DCC conversion when I get to it. #HOScale #ModelRailroad #ModelRailway
A USRA 0-8-0 switcher, brass, from Tenshodo. Also, two structure kits for cheap. The loco will be a fun DCC conversion when I get to it. #HOScale #ModelRailroad #ModelRailway
October 4, 2026 at 2:52 PM
Local model railroad club show find: from the RailFair nvrra.com/content.aspx...
A USRA 0-8-0 switcher, brass, from Tenshodo. Also, two structure kits for cheap. The loco will be a fun DCC conversion when I get to it. #HOScale #ModelRailroad #ModelRailway
A USRA 0-8-0 switcher, brass, from Tenshodo. Also, two structure kits for cheap. The loco will be a fun DCC conversion when I get to it. #HOScale #ModelRailroad #ModelRailway
Quality trumps proximity to a hospital · Ankle fracture: Surgery isn't always necessary · Female brains recover differently · Multiple sclerosis: Drug reverses paralysis · Second opinion now also available for left heart catheterization
🎧 40/26 English Audio Edition
The provided weekly briefing highlights recent advancements and discussions across medicine, technology, and public health. A notable trend report reveals that patients prioritize **treatment outcomes** over clinic proximity when selecting a hospital. In orthopedics, new guidelines suggest that certain ankle fractures can heal successfully with **early physical loading** rather than rigid immobilization or immediate surgery. Research involving anesthesia recovery demonstrates that **brain immune cells** facilitate neural rewiring specifically in female subjects. Additionally, experimental treatments utilizing specific drug compounds show potential in **reversing paralysis** in multiple sclerosis models, while regulatory updates now grant patients the right to seek a **second medical opinion** prior to undergoing elective heart catheterizations.
English Edition MINQs weekly 40 26
0:00
/1451.316825
1×
weeklypicks.minq-media.de
October 3, 2026 at 8:00 AM
Quality trumps proximity to a hospital · Ankle fracture: Surgery isn't always necessary · Female brains recover differently · Multiple sclerosis: Drug reverses paralysis · Second opinion now also available for left heart catheterization
Talus Bio looks beyond protein structures with new AI drug discovery model firstwordhealthtech.com/story/8151764
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firstwordhealthtech.com
October 2, 2026 at 1:06 AM
Talus Bio looks beyond protein structures with new AI drug discovery model firstwordhealthtech.com/story/8151764
💉⏱️ A nerve block that lasts weeks instead of hours?
Researchers created a slow-release formulation that produced local anesthesia for 2–3 weeks in rats.
The work is still at the preclinical stage but represents an intriguing example of innovation in drug delivery.
🔗 www.nature.com/articles/s41...
Researchers created a slow-release formulation that produced local anesthesia for 2–3 weeks in rats.
The work is still at the preclinical stage but represents an intriguing example of innovation in drug delivery.
🔗 www.nature.com/articles/s41...
Ultra-slow release of hydrophilic drugs via multilamellar–multivesicular liposomes formed by unsaturated phospholipids - Nature Biomedical Engineering
Contrary to expectations that unsaturation accelerates release, unsaturated phospholipid liposomes showed 3-fold higher loading and markedly reduced initial and sustained release due to multilamellar–...
www.nature.com
October 1, 2026 at 5:49 PM
💉⏱️ A nerve block that lasts weeks instead of hours?
Researchers created a slow-release formulation that produced local anesthesia for 2–3 weeks in rats.
The work is still at the preclinical stage but represents an intriguing example of innovation in drug delivery.
🔗 www.nature.com/articles/s41...
Researchers created a slow-release formulation that produced local anesthesia for 2–3 weeks in rats.
The work is still at the preclinical stage but represents an intriguing example of innovation in drug delivery.
🔗 www.nature.com/articles/s41...
Localized drug delivery could improve how #chemotherapy reaches tumors.
This study develops porous PCL/PEG/PLA #scaffolds for #doxorubicin delivery, with polymer composition tuning drug loading and sustained release for up to 720 hours.
#OpenAccess in #ePolymers: doi.org/10.1515/epol...
This study develops porous PCL/PEG/PLA #scaffolds for #doxorubicin delivery, with polymer composition tuning drug loading and sustained release for up to 720 hours.
#OpenAccess in #ePolymers: doi.org/10.1515/epol...
September 29, 2026 at 1:30 PM
Localized drug delivery could improve how #chemotherapy reaches tumors.
This study develops porous PCL/PEG/PLA #scaffolds for #doxorubicin delivery, with polymer composition tuning drug loading and sustained release for up to 720 hours.
#OpenAccess in #ePolymers: doi.org/10.1515/epol...
This study develops porous PCL/PEG/PLA #scaffolds for #doxorubicin delivery, with polymer composition tuning drug loading and sustained release for up to 720 hours.
#OpenAccess in #ePolymers: doi.org/10.1515/epol...
🎯 ROS-responsive COF from γ-cyclodextrin + folate targeting = #oral #delivery for UC! FER@COF-FA shows high #drug #loading, ROS scavenging, sustained #release & superior efficacy vs free ferulic acid in DSS colitis model.
👉 doi.org/10.3390/phar...
#DrugDelivery #OrganicFramework
👉 doi.org/10.3390/phar...
#DrugDelivery #OrganicFramework
September 29, 2026 at 10:46 AM
🎯 ROS-responsive COF from γ-cyclodextrin + folate targeting = #oral #delivery for UC! FER@COF-FA shows high #drug #loading, ROS scavenging, sustained #release & superior efficacy vs free ferulic acid in DSS colitis model.
👉 doi.org/10.3390/phar...
#DrugDelivery #OrganicFramework
👉 doi.org/10.3390/phar...
#DrugDelivery #OrganicFramework
“Roche plans to move towards autonomous AI labs for drug R&D, the Swiss pharmaceutical company said at its Pharma Day presentation on Monday. As its labs become more autonomous, Roche envisions its scientists moving from operating and assisting with experiments towards approving and auditing”
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firstwordpharma.com
September 29, 2026 at 2:52 AM
“Roche plans to move towards autonomous AI labs for drug R&D, the Swiss pharmaceutical company said at its Pharma Day presentation on Monday. As its labs become more autonomous, Roche envisions its scientists moving from operating and assisting with experiments towards approving and auditing”