YouTube video by Nirvana - Topic

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YouTube video by The Ed Sullivan Show

YouTube video by AlbertAtreides

YouTube video by Nirvana - Topic

YouTube video by sallie6

This study identifies 11 IFNAR1 alleles impairing IFN-α/ω responses but sparing IFN-β, including an allele common in Southern China (P335del). Heterozygous

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Tissue damage activates immediate responses to restrict further harm and initiate repair. How injury sensing is coupled to regeneration is still not well understood. Here, we study regenerative responses in the adult Drosophila brain, where proliferation is normally strongly restricted. We show that localized brain damage triggers oxidative stress and diverse brain protective programs. We find that ROS generation by the NADPH Oxidase Duox in glial cells is responsible for injury-induced oxidative stress. Both genetic and chemical suppression of ROS in injured brains impairs regeneration. In particular, selective knockdown of calcium-sensitive Duox in glia, which show elevated calcium after injury, reduces injury-induced proliferation. We further provide evidence that diffusing ROS can sustain the activity of pro-regenerative signaling, which is required to stimulate cell divisions. Although oxidative stress is generally considered as harmful in the brain, we uncover here an unanticipat

The initiator caspase Dronc can trigger apoptosis-induced proliferation (AiP), a specific form of compensatory proliferation. This study shows that Dronc-dependent Ca2+ influx into the cytosol is an important contributor of AiP and activation of the NADPH oxidase DUOX in Drosophila, and that this process may be conserved in vertebrates.