2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids but not in infant jejunal enteroids that have significantly lower expression of α1–2-fucosylated glycans @sashi-ramani.bsky.social bit.ly/4h45vsG
#glycotime
#glycotime
January 22, 2025 at 8:02 AM
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids but not in infant jejunal enteroids that have significantly lower expression of α1–2-fucosylated glycans @sashi-ramani.bsky.social bit.ly/4h45vsG
#glycotime
#glycotime
Development of rhesus macaque enteroids and enteroid-derived cell lines for enteric calicivirus infections journals.asm.org/doi/10.1128/...
journals.asm.org
September 28, 2026 at 3:35 PM
Development of rhesus macaque enteroids and enteroid-derived cell lines for enteric calicivirus infections journals.asm.org/doi/10.1128/...
We are live on bluesky. Together with @meganstanifer.bsky.social we love organoids enteroids and enteric viruses. We also found type III interferon fascinating.
January 23, 2025 at 2:13 AM
We are live on bluesky. Together with @meganstanifer.bsky.social we love organoids enteroids and enteric viruses. We also found type III interferon fascinating.
Currently, there are no licensed vaccines for noroviruses. Several promising candidate vaccines are under development, including a mRNA vaccine made by Moderna. 13/n END www.nature.com/articles/s41...
Bivalent norovirus mRNA vaccine elicits cellular and humoral responses protecting human enteroids from GII.4 infection - npj Vaccines
npj Vaccines - Bivalent norovirus mRNA vaccine elicits cellular and humoral responses protecting human enteroids from GII.4 infection
www.nature.com
January 7, 2025 at 2:13 PM
Currently, there are no licensed vaccines for noroviruses. Several promising candidate vaccines are under development, including a mRNA vaccine made by Moderna. 13/n END www.nature.com/articles/s41...
New studies developing the model of Human Jejunal Enteroids HJEs in preclinical for L cell biology, GLP-1 secretion and enteroendocrine dysfunction. #diabetes www.nature.com/articles/s41...
Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells - International Journal of Obesity
International Journal of Obesity - Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells
www.nature.com
February 10, 2026 at 11:32 AM
New studies developing the model of Human Jejunal Enteroids HJEs in preclinical for L cell biology, GLP-1 secretion and enteroendocrine dysfunction. #diabetes www.nature.com/articles/s41...
A paper using RRID:AB_143165 from @thermofishersci.bsky.social was just published in iScience. RRIDs improve reproducibility in scientific research. #methodsmatter #RRID #STMpublishing
Proteomic and functional profiling of suspended jejunal enteroids reveals pharmacokinetic fidelity to native intestine
Read the full paper: Proteomic and functional profiling of suspended jejunal enteroids reveals pharmacokinetic fidelity to native intestine
doi.org
October 2, 2026 at 7:00 AM
A paper using RRID:AB_143165 from @thermofishersci.bsky.social was just published in iScience. RRIDs improve reproducibility in scientific research. #methodsmatter #RRID #STMpublishing
Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids | mBio
Pathogenic bacteria employ partially overlapping sets of virulence factor functions
to colonize host epithelia but can differ markedly in their pathogenesis and disease
kinetics. This work combines ba...
journals.asm.org
May 30, 2025 at 1:45 PM
Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Study: SARS-CoV-2 Omicron BA.2.86 and JN.1 expand tropism in human proximal intestinal epithelium.
Published: 05 June 2026
www.nature.com/articles/s41...
Published: 05 June 2026
www.nature.com/articles/s41...
SARS-CoV-2 Omicron BA.2.86 and JN.1 expand tropism in human proximal intestinal epithelium - Nature Communications
EG.5.1 uses dual entry pathways and replicates better in alveolar cells. BA.2.86 and JN.1 depend on TMPRSS2 for airway entry but replicate more efficiently in intestinal enteroids, with JN.1 showing i...
www.nature.com
June 9, 2026 at 1:23 AM
Study: SARS-CoV-2 Omicron BA.2.86 and JN.1 expand tropism in human proximal intestinal epithelium.
Published: 05 June 2026
www.nature.com/articles/s41...
Published: 05 June 2026
www.nature.com/articles/s41...
Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids https://www.biorxiv.org/content/10.1101/2025.05.22.655571v1
May 23, 2025 at 7:18 AM
Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids https://www.biorxiv.org/content/10.1101/2025.05.22.655571v1
By Guty Schnauzer:
"This work provides experimental evidence that the Omicron BA.2.86 and JN.1 variants have developed a greater capacity to infect human proximal small intestine cells, something that distinguishes them from other recent XBB-derived variants."
X source: x.com/guty2370/sta...
"This work provides experimental evidence that the Omicron BA.2.86 and JN.1 variants have developed a greater capacity to infect human proximal small intestine cells, something that distinguishes them from other recent XBB-derived variants."
X source: x.com/guty2370/sta...
June 9, 2026 at 1:23 AM
By Guty Schnauzer:
"This work provides experimental evidence that the Omicron BA.2.86 and JN.1 variants have developed a greater capacity to infect human proximal small intestine cells, something that distinguishes them from other recent XBB-derived variants."
X source: x.com/guty2370/sta...
"This work provides experimental evidence that the Omicron BA.2.86 and JN.1 variants have developed a greater capacity to infect human proximal small intestine cells, something that distinguishes them from other recent XBB-derived variants."
X source: x.com/guty2370/sta...
The preprint tests infection of different SARS-CoV-2 variants in organoids, including enteroids (basically intestinal organoids), finding that the BA.2.86-derived variant JN.1, and BA.2.86 replicate much more efficiently in the enteroids than previous variants.
September 2, 2024 at 5:31 PM
The preprint tests infection of different SARS-CoV-2 variants in organoids, including enteroids (basically intestinal organoids), finding that the BA.2.86-derived variant JN.1, and BA.2.86 replicate much more efficiently in the enteroids than previous variants.
With #norovirus in the news everywhere, here is a timely new paper in collaboration with @drlarsbode.bsky.social showing reduced virus replication in 8 different #enteroid lines treated with #HMO 2'FL! The surprise? Enteroids from babies did NOT show this effect! pubmed.ncbi.nlm.nih.gov/39791912/
2'-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids - PubMed
Human noroviruses infect the gastrointestinal tract and are a leading cause of acute gastroenteritis worldwide. Common symptoms of norovirus include diarrhea, vomiting, and stomach cramps. Virus shedd...
pubmed.ncbi.nlm.nih.gov
January 12, 2025 at 9:39 PM
With #norovirus in the news everywhere, here is a timely new paper in collaboration with @drlarsbode.bsky.social showing reduced virus replication in 8 different #enteroid lines treated with #HMO 2'FL! The surprise? Enteroids from babies did NOT show this effect! pubmed.ncbi.nlm.nih.gov/39791912/
FOXP3-engineered regulatory T cells restore intestinal barrier integrity in Crohn's disease enteroids via PDGF-AA https://www.biorxiv.org/content/10.64898/2026.05.25.727767v1
May 29, 2026 at 7:16 AM
FOXP3-engineered regulatory T cells restore intestinal barrier integrity in Crohn's disease enteroids via PDGF-AA https://www.biorxiv.org/content/10.64898/2026.05.25.727767v1
25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids journals.asm.org/doi/10.1128/...
25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids | Journal of Virology
Human noroviruses are a leading cause of both epidemic and endemic acute gastroenteritis
worldwide. Currently, there are no licensed vaccines or antiviral treatments available.
The immune response to ...
journals.asm.org
October 21, 2025 at 2:31 PM
25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids journals.asm.org/doi/10.1128/...
All Vγ subsets were affected, but the most striking reduction was in Vγ7 IELs. We connected the dots to find that that epithelial HNF4G/BTNL signaling was impaired, thus Vγ7 IELs failed to expand. Further, TNF exposure was sufficient to downregulate HNF4G/BTNL in murine and human enteroids. 3/n
March 22, 2025 at 8:05 PM
All Vγ subsets were affected, but the most striking reduction was in Vγ7 IELs. We connected the dots to find that that epithelial HNF4G/BTNL signaling was impaired, thus Vγ7 IELs failed to expand. Further, TNF exposure was sufficient to downregulate HNF4G/BTNL in murine and human enteroids. 3/n
Could a common breast milk compound be used to treat norovirus?
Interesting new research:
pubmed.ncbi.nlm.nih.gov/39791912/
Interesting new research:
pubmed.ncbi.nlm.nih.gov/39791912/
2'-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids - PubMed
Human noroviruses infect the gastrointestinal tract and are a leading cause of acute gastroenteritis worldwide. Common symptoms of norovirus include diarrhea, vomiting, and stomach cramps. Virus shedd...
pubmed.ncbi.nlm.nih.gov
January 27, 2025 at 4:55 AM
Could a common breast milk compound be used to treat norovirus?
Interesting new research:
pubmed.ncbi.nlm.nih.gov/39791912/
Interesting new research:
pubmed.ncbi.nlm.nih.gov/39791912/
Human jejunal enteroids for studies of epithelial drug transport and metabolism https://www.biorxiv.org/content/10.1101/2025.03.17.643545v1
March 18, 2025 at 1:30 AM
Human jejunal enteroids for studies of epithelial drug transport and metabolism https://www.biorxiv.org/content/10.1101/2025.03.17.643545v1
Join our next Webinar on #MPS Systems 😍
🦠Unraveling #hepatitis E virus replication in the gut using human intestinal #enteroids and a #gut-on-chip
🔬 Patient derived #tumoroid to model rectal #cancer under radiotherapy
📅 16 October, 4-5 PM CEST
sciensano.webex.com/weblink/regi...
🦠Unraveling #hepatitis E virus replication in the gut using human intestinal #enteroids and a #gut-on-chip
🔬 Patient derived #tumoroid to model rectal #cancer under radiotherapy
📅 16 October, 4-5 PM CEST
sciensano.webex.com/weblink/regi...
October 1, 2025 at 12:49 PM
Join our next Webinar on #MPS Systems 😍
🦠Unraveling #hepatitis E virus replication in the gut using human intestinal #enteroids and a #gut-on-chip
🔬 Patient derived #tumoroid to model rectal #cancer under radiotherapy
📅 16 October, 4-5 PM CEST
sciensano.webex.com/weblink/regi...
🦠Unraveling #hepatitis E virus replication in the gut using human intestinal #enteroids and a #gut-on-chip
🔬 Patient derived #tumoroid to model rectal #cancer under radiotherapy
📅 16 October, 4-5 PM CEST
sciensano.webex.com/weblink/regi...
Overcoming host restrictions to enable continuous passaging of GII.3 human norovirus in human intestinal enteroids
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
February 5, 2026 at 1:11 AM
Overcoming host restrictions to enable continuous passaging of GII.3 human norovirus in human intestinal enteroids
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
TODAY @ 4PM CST ‼️ We've got a special back-to-back for y'all 🤠
Dr. @sohinibanerjee.bsky.social will discuss her research on #infant #enteroids as a model for the developing gut!
Then, Dr. Yang Yang from McGovern Medical School will share what she's learned about COX-2 in the context of #IBD.
Dr. @sohinibanerjee.bsky.social will discuss her research on #infant #enteroids as a model for the developing gut!
Then, Dr. Yang Yang from McGovern Medical School will share what she's learned about COX-2 in the context of #IBD.
April 17, 2025 at 7:03 PM
TODAY @ 4PM CST ‼️ We've got a special back-to-back for y'all 🤠
Dr. @sohinibanerjee.bsky.social will discuss her research on #infant #enteroids as a model for the developing gut!
Then, Dr. Yang Yang from McGovern Medical School will share what she's learned about COX-2 in the context of #IBD.
Dr. @sohinibanerjee.bsky.social will discuss her research on #infant #enteroids as a model for the developing gut!
Then, Dr. Yang Yang from McGovern Medical School will share what she's learned about COX-2 in the context of #IBD.
A paper using RRID:AB_1107784 from @bioxcell.bsky.social was just published. Thanks for making your methods matter! #STMpublishing #BetterScience #OpenScience
FOXP3-engineered regulatory T cells restore intestinal barrier integrity in Crohn’s disease enteroids via PDGF-AA
Read the full paper: FOXP3-engineered regulatory T cells restore intestinal barrier integrity in Crohn’s disease enteroids via PDGF-AA
doi.org
June 5, 2026 at 7:01 AM
A paper using RRID:AB_1107784 from @bioxcell.bsky.social was just published. Thanks for making your methods matter! #STMpublishing #BetterScience #OpenScience
RRIDs were included in this in International Journal of Obesity paper. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #accelerateopenscience
Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells - International Journal of Obesity
Read the full paper: Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells
doi.org
April 12, 2026 at 7:00 AM
RRIDs were included in this in International Journal of Obesity paper. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #accelerateopenscience
Potential therapeutic for norovirus gastroenteritis:
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids
journals.asm.org/doi/10.1128/...
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids
journals.asm.org/doi/10.1128/...
January 11, 2025 at 1:27 AM
Potential therapeutic for norovirus gastroenteritis:
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids
journals.asm.org/doi/10.1128/...
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids
journals.asm.org/doi/10.1128/...
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids journals.asm.org/doi/10.1128/...
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids | Journal of Virology
Human noroviruses infect the gastrointestinal tract and are a leading cause of acute
gastroenteritis worldwide. Common symptoms of norovirus include diarrhea, vomiting,
and stomach cramps. Virus shedd...
journals.asm.org
January 10, 2025 at 5:37 PM
2′-Fucosyllactose inhibits human norovirus replication in human intestinal enteroids journals.asm.org/doi/10.1128/...
Meanwhile, a complementary paper was published in April 2024 by scientists from the Oregon Health & Science University, titled "Neonatal enteroids absorb extracellular vesicles from human milk-fed infant digestive fluid".
April 17, 2025 at 8:58 AM
Meanwhile, a complementary paper was published in April 2024 by scientists from the Oregon Health & Science University, titled "Neonatal enteroids absorb extracellular vesicles from human milk-fed infant digestive fluid".