🚨 BREAKTHROUGH: 18-year-old Arya Satheesh from Ireland has developed a plant-based plastic that can biodegrade and release an enzyme that helps break down other plastic waste.
A plastic that could actually help clean up plastic waste.
A plastic that could actually help clean up plastic waste.
September 30, 2026 at 1:38 PM
🚨 BREAKTHROUGH: 18-year-old Arya Satheesh from Ireland has developed a plant-based plastic that can biodegrade and release an enzyme that helps break down other plastic waste.
A plastic that could actually help clean up plastic waste.
A plastic that could actually help clean up plastic waste.
QMzyme: A Python Package for Automated and Systematic QM-based Enzyme Modeling
QMzyme: A Python Package for Automated and Systematic QM-based Enzyme Modeling | ChemRxiv
We introduce QMzyme, a Python package to automate the generation of Quantum mechanics (QM)-based enzyme models. QM calculations on enzymes are computationally challenging because full enzyme systems t...
chemrxiv.org
October 2, 2026 at 9:02 AM
QMzyme: A Python Package for Automated and Systematic QM-based Enzyme Modeling
Enzyme-based strategies are advancing cancer immunotherapy by remodeling the tumor-associated extracellular matrix and glycocalyx barriers.
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42812522/
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42812522/
October 2, 2026 at 5:56 AM
Enzyme-based strategies are advancing cancer immunotherapy by remodeling the tumor-associated extracellular matrix and glycocalyx barriers.
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42812522/
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42812522/
Oh, fuck, I just remembered the whole "milk is based because nordic enzyme retention" thing.
March 21, 2026 at 6:35 PM
Oh, fuck, I just remembered the whole "milk is based because nordic enzyme retention" thing.
A technology feature in Nature describes how enzyme-based techniques and refinements in organic chemistry are easing the generation of extended DNA sequences. 🧬 🧪
Made-to-order DNA goes big: new tech doubles size of custom genetic sequences
Enzyme-based techniques and refinements in organic chemistry ease the generation of extended DNA sequences.
go.nature.com
July 28, 2025 at 4:16 AM
A technology feature in Nature describes how enzyme-based techniques and refinements in organic chemistry are easing the generation of extended DNA sequences. 🧬 🧪
A technology feature in Nature describes how enzyme-based techniques and refinements in organic chemistry are easing the generation of extended DNA sequences. 🧬 🧪
Made-to-order DNA goes big: new tech doubles size of custom genetic sequences
Enzyme-based techniques and refinements in organic chemistry ease the generation of extended DNA sequences.
go.nature.com
August 1, 2025 at 1:11 AM
A technology feature in Nature describes how enzyme-based techniques and refinements in organic chemistry are easing the generation of extended DNA sequences. 🧬 🧪
It’s an RNA world. RNA is posited to be the first genetic material, arising 4 billion years ago. It can store information and act as an enzyme. Eventually, it duplicated its information into a more stable form, DNA.
February 13, 2026 at 2:17 PM
It’s an RNA world. RNA is posited to be the first genetic material, arising 4 billion years ago. It can store information and act as an enzyme. Eventually, it duplicated its information into a more stable form, DNA.
Enzyme–cell beads retained their functions after five months of storage. These hybrid catalysts could help produce fine chemicals and pharmaceutical building blocks. doi.org/hcmfq3
Enzymes become sturdy beads that could support more sustainable chemical production
Thanks to enzyme-based biocatalysis, an enormous range of pharmaceutical active ingredients and other complex molecules can be synthesized in an environmentally friendly manner.
phys.org
October 2, 2026 at 4:40 PM
Enzyme–cell beads retained their functions after five months of storage. These hybrid catalysts could help produce fine chemicals and pharmaceutical building blocks. doi.org/hcmfq3
The Baker lab seems serious about moving into enzyme design.
Here, they train a flow-matching model that can be conditioned by atomic coordinates and then use it to design enzymes based on active site geometry specified by density functional theory.
www.biorxiv.org/content/10.1...
Here, they train a flow-matching model that can be conditioned by atomic coordinates and then use it to design enzymes based on active site geometry specified by density functional theory.
www.biorxiv.org/content/10.1...
November 15, 2024 at 10:11 PM
The Baker lab seems serious about moving into enzyme design.
Here, they train a flow-matching model that can be conditioned by atomic coordinates and then use it to design enzymes based on active site geometry specified by density functional theory.
www.biorxiv.org/content/10.1...
Here, they train a flow-matching model that can be conditioned by atomic coordinates and then use it to design enzymes based on active site geometry specified by density functional theory.
www.biorxiv.org/content/10.1...
I believe others are also working on microbial- and enzyme-based approaches to break down microplastics: the more (or the less in this case), the better!
October 1, 2026 at 10:11 AM
I believe others are also working on microbial- and enzyme-based approaches to break down microplastics: the more (or the less in this case), the better!
Now if we can just start mass deployment of enzyme based plastic recycling.
December 20, 2023 at 12:18 AM
Now if we can just start mass deployment of enzyme based plastic recycling.
Buying Enzyme-Based Cleaner by the Gallon Because My Elder Guinea Pig Has Guinea Pig IBS: A Memoir by Iva Cheung
November 25, 2025 at 5:44 PM
Buying Enzyme-Based Cleaner by the Gallon Because My Elder Guinea Pig Has Guinea Pig IBS: A Memoir by Iva Cheung
💡Scientists unveil enzyme tech that reduces plastic recycling’s footprint by up to 99%
interestingengineering.com/innovation/e...
interestingengineering.com/innovation/e...
Enzyme breakthrough cuts plastic recycling energy use by 65%
A new enzymatic process cuts costs by 74 percent, slashes chemical use, and recycles PET plastic cleaner than oil-based production.
interestingengineering.com
July 4, 2025 at 6:52 PM
💡Scientists unveil enzyme tech that reduces plastic recycling’s footprint by up to 99%
interestingengineering.com/innovation/e...
interestingengineering.com/innovation/e...
Systematic discovery of enzyme promiscuity in Escherichia coli using in vitro metabolomics www.nature.com/articles/s42... #jcampubs
Systematic discovery of enzyme promiscuity in Escherichia coli using in vitro metabolomics - Communications Biology
Metabolomics-based activity profiling of 667 purified E. coli enzymes reveals a surprising level of promiscuity, with many enzymes catalyzing unexpected reactions.
www.nature.com
May 12, 2026 at 1:36 PM
Systematic discovery of enzyme promiscuity in Escherichia coli using in vitro metabolomics www.nature.com/articles/s42... #jcampubs
So bloodwork showed one fucked liver enzyme and bilirubin which we'd expect. No I don't know which enzyme I haven't actually seen the bloodwork result.
The ultrasound showed nothing too weird except enlarged and 'bright' liver. Which based on the bloodwork and her jaundice, no surprise.
...
The ultrasound showed nothing too weird except enlarged and 'bright' liver. Which based on the bloodwork and her jaundice, no surprise.
...
November 11, 2025 at 10:30 PM
So bloodwork showed one fucked liver enzyme and bilirubin which we'd expect. No I don't know which enzyme I haven't actually seen the bloodwork result.
The ultrasound showed nothing too weird except enlarged and 'bright' liver. Which based on the bloodwork and her jaundice, no surprise.
...
The ultrasound showed nothing too weird except enlarged and 'bright' liver. Which based on the bloodwork and her jaundice, no surprise.
...
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism-based 1,2,3-triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP-ribose (ADPR) adducts from...
onlinelibrary.wiley.com
November 2, 2025 at 1:20 PM
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
It just looks to be a standard plant based plastic with an enzyme mixed in that degrades petroleum based plastics.
It’s not a cheap enzyme; US 2500 for 3 mg
It’s not a cheap enzyme; US 2500 for 3 mg
October 1, 2026 at 3:44 AM
It just looks to be a standard plant based plastic with an enzyme mixed in that degrades petroleum based plastics.
It’s not a cheap enzyme; US 2500 for 3 mg
It’s not a cheap enzyme; US 2500 for 3 mg
A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...
A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism
The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and ...
www.nature.com
February 22, 2026 at 12:29 PM
A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...
RESEARCH | X Pan, V Cracan et al. (Scintillon Institute)
A genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt 🧪
A genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt 🧪
A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism
The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and modulated lipid metabolism in vitro and in a mouse hepatic steatosis model.
dlvr.it
March 21, 2026 at 7:01 PM
RESEARCH | X Pan, V Cracan et al. (Scintillon Institute)
A genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt 🧪
A genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt 🧪
#NatMicroPicks
Sending evolution into overdrive 🔧🦠
A Φ29‑based DNA replication system in E. coli enables stable and targeted hypermutation achieving evolution of enzyme activities within days
#MicroSky
www.nature.com/articles/s41...
Sending evolution into overdrive 🔧🦠
A Φ29‑based DNA replication system in E. coli enables stable and targeted hypermutation achieving evolution of enzyme activities within days
#MicroSky
www.nature.com/articles/s41...
Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system - Nature Biotechnology
Mutational rates of bacterial evolution are increased using an error-prone orthogonal system.
www.nature.com
March 13, 2026 at 12:39 PM
#NatMicroPicks
Sending evolution into overdrive 🔧🦠
A Φ29‑based DNA replication system in E. coli enables stable and targeted hypermutation achieving evolution of enzyme activities within days
#MicroSky
www.nature.com/articles/s41...
Sending evolution into overdrive 🔧🦠
A Φ29‑based DNA replication system in E. coli enables stable and targeted hypermutation achieving evolution of enzyme activities within days
#MicroSky
www.nature.com/articles/s41...
Advances in DNA-synthesis technologies are allowing large volumes of DNA to be pumped out a low cost
go.nature.com/4mrIh2j
go.nature.com/4mrIh2j
Made-to-order DNA goes big: new tech doubles size of custom genetic sequences
Enzyme-based techniques and refinements in organic chemistry ease the generation of extended DNA sequences.
go.nature.com
July 22, 2025 at 2:08 PM
Advances in DNA-synthesis technologies are allowing large volumes of DNA to be pumped out a low cost
go.nature.com/4mrIh2j
go.nature.com/4mrIh2j
Rio de Janeiro researchers tested 5 statin-based compounds and found that two, 426 and 432, inhibit the SARS-CoV-2 PLpro enzyme with IC50 values near 1 µM, showing promise as non-competitive antivirals for COVID-19.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Statine-based peptidomimetics as SARS-CoV-2 Papain-like protease inhibitors: in Silico and in vitro studies - Scientific Reports
Scientific Reports - Statine-based peptidomimetics as SARS-CoV-2 Papain-like protease inhibitors: in Silico and in vitro studies
www.nature.com
July 20, 2025 at 6:53 PM
Rio de Janeiro researchers tested 5 statin-based compounds and found that two, 426 and 432, inhibit the SARS-CoV-2 PLpro enzyme with IC50 values near 1 µM, showing promise as non-competitive antivirals for COVID-19.
www.nature.com/articles/s41...
www.nature.com/articles/s41...