#epithelioid
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folpe-mn-st.bsky.social
#PathSky Hand mass, 32M. Bland spindle cell tumor with collagen trapping- just an FH, right? Also some less bland epithelioid areas. This is a predominantly spindled epithelioid sarcoma- “modulation” from epithelioid to spindled cells is an under appreciated morphological hallmark. See Comment.
Keratin SMARCB1
November 22, 2024 at 2:48 PM
folpe-mn-st.bsky.social
#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?
MUC4.
January 8, 2025 at 5:13 PM
drcyclopath.bsky.social
#TooFarToDiagnose? 🧐
Inflamed nodule.
A. Epithelioid Hemangioma
B. Pseudomyogenic Hemangioendothelioma
C. Epithelioid Hemangioendothelioma
D. Epithelioid Fibrous Histiocytoma
#Pathology #Dermatology #Dermatopathology #DermPath
February 3, 2026 at 3:59 PM
folpe-mn-st.bsky.social
#PathSky 43F with a solitary lung mass. Relatively circumscribed, nests and interesting micropapillae of lightly eosinophilic epithelioid cells. Negative for everything except TFE3. Dx?
TFE3
February 6, 2025 at 9:41 PM
atsblueeditor.bsky.social
Fruits Hanging on the Branches of the Lung: Pulmonary Epithelioid Hemangioendothelioma
@atscommunity.bsky.social #medsky

🔗 tinyurl.com/mu9x3puu
February 21, 2025 at 5:08 PM
folpe-mn-st.bsky.social
#PathSky This one definitely needs more than 4 images, so go to the Comments too. 65F, iliac crest lesion. The original pathologists quite reasonably considered an epithelioid hemangioendothelioma, although it was CAMTA1-negative.
CD31 ERG CAMTA1
December 23, 2024 at 10:45 PM
folpe-mn-st.bsky.social
Epithelioid angiosarcoma with extensive intravascular growth. Obviously there must be a right sided primary. There’s supposed to be a liver mass.
June 5, 2025 at 7:20 PM
folpe-mn-st.bsky.social
This is actually a rather spectacular example of dedifferentiated liposarcoma with epithelioid/ epithelial features, a rather rare but reported phenomenon. pubmed.ncbi.nlm.nih.gov/28719466/
Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features - PubMed
Dedifferentiated liposarcoma (DDLPS) demonstrates a variety of growth patterns, and their histologic resemblance to other spindle cell mesenchymal tumors has been widely recognized. However, epithelio...
pubmed.ncbi.nlm.nih.gov
May 14, 2025 at 3:28 PM
folpe-mn-st.bsky.social
At high power, the cells in this mass are rather bland, epithelioid, and somewhat myoid. HMB45, Melan A and cathepsin K are positive. Lipomatous angiomyolipoma. These can be sneaky….
HMB45
April 23, 2025 at 7:46 PM
pathologyoutlines.bsky.social
Image of the Week!

Submitted by: Selim Nasser, M.D.
Directory Profile: https://buff.ly/41gjWVq
Subspecialty: Clinical pathology
Diagnosis: Malignant Epithelioid Peritoneal Mesothelioma recurring after 5 years

#Pathology #PathologyOutlines #ClinPath #PathSky
February 12, 2025 at 6:59 PM
grunewaldlab.bsky.social
🔥Check out our new article on..

Loss of #SMARCB1 evokes targetable epigenetic vulnerabilities in #epithelioid #sarcoma

onlinelibrary.wiley.com/doi/10.1002/...

@dkfz.bsky.social @KiTZ_HD @nct-heidelberg.bsky.social @uniheidelberg.bsky.social
January 21, 2025 at 8:48 AM
drcyclopath.bsky.social
#TooCloseToDiagnose? 🧐
Vascular lesion.
A. Pseudomyogenic Hemangioendothelioma
B. Epithelioid Hemangioendothelioma
C. Epithelioid Hemangioma
D. Lobular Capillary Hemangioma
#Pathology #Dermatology #Dermatopathology #DermPath
January 28, 2026 at 2:53 PM
grunewaldlab.bsky.social
Multi-omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics

onlinelibrary.wiley.com/doi/10.1002/...
November 28, 2025 at 5:30 PM
andreavictoria25.bsky.social
Please consider donating to Alexandra’s Boston Marathon Dana Farber Cancer Institute fundraiser. She’s running in memory of her childhood friend, Nick who suffered with from Epithelioid hemangioendothelioma (EHE), an ultra rare cancer. Every donation makes a difference. Thank you!
I’m running the Boston Marathon® with Dana-Farber
Support my run against cancer.
danafarber.jimmyfund.org
September 29, 2026 at 12:44 AM
hookonpath.bsky.social
88-year-old with vulvar lesion. Diagnosis: Extramammary Paget's disease.
The basal layer and mid dermis contain large epithelioid cells with ample, delicate cytoplasm scattered in the epidermis as single cells. The large epithelioid cells are positive for CK7. The large epithelioid cells are negative for Melan A. The large epithelioid cells are negative for p63.
December 24, 2024 at 5:08 PM
bio-integration.org
Combined CUS and CEUS showed high specificity and accuracy for distinguishing hepatic #PEComa from HCC, supporting improved preoperative diagnosis. #medsky #Radiology
#BIOI #OpenAccess: doi.org/10.15212/bio...
Differentiating Hepatic Perivascular Epithelioid Cell Tumor from Hepatocellular Carcinoma without High-Risk Factors using Contrast-Enhanced Ultrasound
October 7, 2026 at 12:40 PM
marylandpath.bsky.social
Epithelioid GIST can be tricky, especially when metastatic, as it can present variable histomorphology (neuroendocrine-like, plasmacytoid, atypia, etc.) and aberrant staining patterns (e.g. keratin). This is a liver biopsy. #PathSky #GIpath
March 14, 2025 at 2:13 PM
folpe-mn-st.bsky.social
It’s also got these interesting vacuolated epithelioid cells, which are CD31-pos. The spindled cells express SMA. Nice example of spindle cell hemangioma, an IDH1/2 mutated benign vascular tumor strongly associated with skeletal cartilage tumors (Mafucci syndrome).
SMA CD31
February 5, 2025 at 7:02 PM
koppenverklapt.bsky.social
Epithelioïd sarcoom, een zeldzame, kwaadaardige tumor die ontstaat in de cellen van de bloedvaten

www.ad.nl/show/duits-t...
Kop van het AD: Duits tv-icoon Thomas Gottschalk (75) is ernstig ziek: ‘De diagnose was vernietigend’
December 1, 2025 at 4:28 PM
lucasmassoth.bsky.social
Intrauterine perivascular epithelioid tumor (PEComa) exhibiting HMB45 expression by IHC. This lesion was small and lacked atypia or mitotic activity, predicting benign behavior.

#pathsky #medsky #pathology
November 13, 2024 at 2:29 AM
jci.org
DNA damage provides a bright spot in rhabdoid & epithelioid sarcomas

Alex Kentsis @kentsisresearch.bsky.social @oleg8r.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
October 23, 2025 at 4:15 PM
folpe-mn-st.bsky.social
pubmed.ncbi.nlm.nih.gov/38621503/
GLI1 Coamplification in Well-Differentiated/Dedifferentiated Liposarcomas: Clinicopathologic and Molecular Analysis of 92 Cases - PubMed
GLI1(12q13.3) amplification is identified in a subset of mesenchymal neoplasms with a distinct nested round cell/epithelioid phenotype. MDM2 and CDK4 genes are situated along the oncogenic 12q13-15 se...
pubmed.ncbi.nlm.nih.gov
June 12, 2025 at 9:11 PM
folpe-mn-st.bsky.social
It was sent out, and another place called it an epithelioid hemangioma. Interesting idea, because it does have some capillary-type channels. But not very epithelioid, and FOSB was negative (not shown).
December 23, 2024 at 10:47 PM
insightsimaging.bsky.social
🎄 Neoplastic condition: Pulmonary epithelioid hemangioendothelioma presents as bilateral randomly distributed, well or ill-defined multiple parenchymal nodules.
December 8, 2024 at 11:00 AM
drcyclopath.bsky.social
2nd chance!
What is the diagnosis?
A. Epithelioid Hemangioma
B. Pseudomyogenic Hemangioendothelioma
C. Epithelioid Hemangioendothelioma
D. Epithelioid Fibrous Histiocytoma
February 3, 2026 at 3:59 PM