This week in #Science #Immunology: Lukas Amann, Marco Prinz, & colleagues at @uni-freiburg.de report that #extrasinusoidal #macrophages in the #mouse #DuraMater represent a distinct subset of #CNS -associated macrophages whose role is shaped by #autoimmune #neuroinflammation! #neuroimmunology
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.
www.science.org
December 20, 2024 at 9:48 PM
This week in #Science #Immunology: Lukas Amann, Marco Prinz, & colleagues at @uni-freiburg.de report that #extrasinusoidal #macrophages in the #mouse #DuraMater represent a distinct subset of #CNS -associated macrophages whose role is shaped by #autoimmune #neuroinflammation! #neuroimmunology
Scientists have identified the characteristics of #macrophages in the dura mater, revealing their distinct markers and behaviors during homeostasis and autoimmune neuroinflammation in mice.
Read more in #ScienceImmunology:
Read more in #ScienceImmunology:
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.
scim.ag
January 21, 2025 at 7:56 PM
Scientists have identified the characteristics of #macrophages in the dura mater, revealing their distinct markers and behaviors during homeostasis and autoimmune neuroinflammation in mice.
Read more in #ScienceImmunology:
Read more in #ScienceImmunology:
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/full/10....
www.science.org/doi/full/10....
December 23, 2024 at 2:36 PM
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
December 20, 2024 at 7:06 PM
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
For context, a 'extrasinusoidal' macrophages are macs NOT near sagittal (between the cerebral hemispheres) & transverse sinuses (sit between the cerebral hemispheres & cerebellum) - nice diagram to show this from their Fig S1 👇
December 21, 2024 at 2:38 PM
For context, a 'extrasinusoidal' macrophages are macs NOT near sagittal (between the cerebral hemispheres) & transverse sinuses (sit between the cerebral hemispheres & cerebellum) - nice diagram to show this from their Fig S1 👇
🤩 paper in on extrasinusoidal macrophages in 🐭 dura from Marco Prinz's group led by Lukas Amann @uni-freiburg.de - this is a VERY comprehensive paper, lots to ❤️ but their role in phagocytosing dying neurophils at both the onset & peak of EAE neuroinflammation is quite interesting 🧪 #ImmunoSky 🧠
December 21, 2024 at 2:29 PM
🤩 paper in on extrasinusoidal macrophages in 🐭 dura from Marco Prinz's group led by Lukas Amann @uni-freiburg.de - this is a VERY comprehensive paper, lots to ❤️ but their role in phagocytosing dying neurophils at both the onset & peak of EAE neuroinflammation is quite interesting 🧪 #ImmunoSky 🧠
Our new study on Dura Mater macrophages regulating #brain #immunity at the interface between the brain and periphery - congrats Lukas Amann 💪💪💪
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages | Science Immunology
www.science.org/doi/10.1126/...
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages | Science Immunology
www.science.org/doi/10.1126/...
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.
www.science.org
December 21, 2024 at 11:23 AM
Our new study on Dura Mater macrophages regulating #brain #immunity at the interface between the brain and periphery - congrats Lukas Amann 💪💪💪
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages | Science Immunology
www.science.org/doi/10.1126/...
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages | Science Immunology
www.science.org/doi/10.1126/...
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.
www.science.org
December 21, 2024 at 12:47 PM
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Extrasinusoidal dural macrophages were distinct from leptomeningeal and CNS parenchymal macrophages in terms of their origin, expansion kinetics, and transcriptional profiles. During autoimmune neuroinflammation, extrasinusoidal dural macrophages performed efferocytosis of apoptotic granulocytes.
January 1, 2025 at 3:33 PM
Extrasinusoidal dural macrophages were distinct from leptomeningeal and CNS parenchymal macrophages in terms of their origin, expansion kinetics, and transcriptional profiles. During autoimmune neuroinflammation, extrasinusoidal dural macrophages performed efferocytosis of apoptotic granulocytes.
The results highlight a previously unappreciated myeloid cell diversity and provide insights into the brain’s innate immune system. @natrevimmunol.bsky.social
www.science.org/doi/10.1126/...
PDF
www.science.org/doi/pdf/10.1...
www.science.org/doi/10.1126/...
www.science.org/doi/pdf/10.1...
Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
Extrasinusoidal dural macrophages are a distinct subset of immunologically active central nervous system–associated macrophages.
www.science.org
January 1, 2025 at 3:35 PM
The results highlight a previously unappreciated myeloid cell diversity and provide insights into the brain’s innate immune system. @natrevimmunol.bsky.social
www.science.org/doi/10.1126/...
PDF
www.science.org/doi/pdf/10.1...
www.science.org/doi/10.1126/...
www.science.org/doi/pdf/10.1...
Although the loss of Tln1 strongly impeded the formation of cellular protrusions by extrasinusoidal dural macrophages, they were still efficiently sampling soluble dextran, which is taken up via receptor-mediated endocytosis, for example through binding to CD206
January 1, 2025 at 3:28 PM
Although the loss of Tln1 strongly impeded the formation of cellular protrusions by extrasinusoidal dural macrophages, they were still efficiently sampling soluble dextran, which is taken up via receptor-mediated endocytosis, for example through binding to CD206