Six proteomic clocks detect a younger biological age signal in an IPF trial – but separating geroprotection from treatment remains key.

Six proteomic clocks detect a younger biological age signal in an IPF trial – but separating geroprotection from treatment remains key.

Cell 188, ◼◼◼–◼◼◼.e1–e33; September 18, 2025

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activities.

AI-based aging clock secures nearly €100K in federal funding for cross-species age prediction and geroprotection research.

The immune system is a key contributor to organismal aging. Here, Ping et al. leverage single-cell multi-omics to construct a human immune aging clock, which pinpoints T cells as an aging nexus. RUNX1 orchestrates a transcriptional network that restrains T cell senescence. Restoring RUNX1 functionally rejuvenates aged human T cells, offering a strategy for geroprotection.

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Aging is the primary risk factor for cancer, dementia, and cardiovascular diseases. As the understanding of the biology of aging constantly improves, there are already initial approaches to geroprotection, which seeks to reduce the age-related risk of disease and thus extend healthy lifespan.

In the study, "Systematic profiling reveals betaine as an exercise mimetic for geroprotection," published in Cell, researchers designed an integrated multi-omics analysis to compare acute and long-term exercise impacts in humans.

**Abstract:** This research introduces a novel framework for personalized geroprotection centered on hyperdimensional mapping of cellular senescence heterogeneity. Current aging research often overlooks the complex, multi-faceted nature of cellular senescence within individual organisms. This approach leverages hyperdimensional computing to capture and analyze variations in senescence-associated secretory phenotype (SASP) profiles, genomic instability markers, and mitochondrial dysfunction indicators, generating a high-resolution 'senescence fingerprint' for each cell population.

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Betaine, Exercise-in-a-pill, Geroprotection

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Exercise has well-established health benefits, yet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics …

Cell 188, 5403–5425.e1–e33; September 18, 2025

Senolysis holds promise for geroprotection but is limited by efficacy and safety; here we show that Celastrol, a pentacyclic triterpenoid, surpasses benchmark agents ABT-263 and fisetin in senolytic ...