Six proteomic clocks detect a younger biological age signal in an IPF trial – but separating geroprotection from treatment remains key.

Six proteomic clocks detect a younger biological age signal in an IPF trial – but separating geroprotection from treatment remains key.

The immune system is a key contributor to organismal aging. Here, Ping et al. leverage single-cell multi-omics to construct a human immune aging clock, which pinpoints T cells as an aging nexus. RUNX1 orchestrates a transcriptional network that restrains T cell senescence. Restoring RUNX1 functionally rejuvenates aged human T cells, offering a strategy for geroprotection.

Senolysis holds promise for geroprotection but is limited by efficacy and safety; here we show that Celastrol, a pentacyclic triterpenoid, surpasses benchmark agents ABT-263 and fisetin in senolytic ...

Cell 188, 5403–5425.e1–e33; September 18, 2025

**Abstract:** This research introduces a novel framework for personalized geroprotection centered on hyperdimensional mapping of cellular senescence heterogeneity. Current aging research often overlooks the complex, multi-faceted nature of cellular senescence within individual organisms. This approach leverages hyperdimensional computing to capture and analyze variations in senescence-associated secretory phenotype (SASP) profiles, genomic instability markers, and mitochondrial dysfunction indicators, generating a high-resolution 'senescence fingerprint' for each cell population.

Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles. Th...

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles. These geroprotective effects are partially mediated through NRF2 pathway activation, supporting vitamin C as a translatable nutritional strategy to combat reproductive aging.

Betaine, Exercise-in-a-pill, Geroprotection

Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles. These geroprotective effects are partially mediated through NRF2 pathway activation, supporting vitamin C as a translatable nutritional strategy to combat reproductive aging.

Cell 188, ◼◼◼–◼◼◼.e1–e33; September 18, 2025

Betaine, Exercise-in-a-pill, Geroprotection

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

In the study, "Systematic profiling reveals betaine as an exercise mimetic for geroprotection," published in Cell, researchers designed an integrated multi-omics analysis to compare acute and long-term exercise impacts in humans.

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...