Nature Reviews Microbiology, Published online: 12 August 2025; doi:10.1038/s41579-025-01232-4New research by Cho et al. shows that structural variations in a glycolipid present on Gram-negative bacteria can modulate gut inflammatory responses.

Nature Reviews Microbiology, Published online: 12 August 2025; doi:10.1038/s41579-025-01232-4New research by Cho et al. shows that structural variations in a glycolipid present on Gram-negative bacteria can modulate gut inflammatory responses.

The glycolipid transfer protein (GLTP) has been proposed to function as a sensor and regulator of glycosphingolipid homeostasis in the cell, as levels of GLTP directly influence the quantities of many...

Here the authors investigate of the structural basis of substrate recognition and the catalytic mechanism of the mannosyltransferase PimE, which is crucial for the biosynthesis of phosphatidyl-myo-ino...

Structural variations in the number of acyl chains and phosphate groups of gram-negative microbial lipid A differentially modulate DC-derived IFN-β responses, which are mechanistically regulated by TLR4 endocytosis and lipid droplet formation. This lipid A-structure-driven immunomodulation via IFN-β contributes to the maintenance of colonic RORγt+ Tregs during homeostasis and helps mitigate colonic inflammation.

Heterocytes, specialized cells for nitrogen fixation in cyanobacteria, are surrounded by heterocyte glycolipids (HGs), which contribute to protecti...

Siglecs are immunoregulatory lectins with very similar architectures. The authors show how the V-set domain of Siglec-6 allows it to select for precise sialylation patterns in specific biological envi...

Cough drives respiratory pathogen transmission, yet how microbes directly engage host sensory neurons to trigger cough is largely unknown. We previously demonstrated that the Mycobacterium tuberculosi...

Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynam...

MacDonald et al. show that EGF triggers de-sialylation of plasma membrane glycoproteins like integrins in a mechanism that depends on the Na+/H+ antiporter NHE1 and the neuraminidases Neu1 and Neu3. I...