In glycomics, two data repositories, GlycoPOST and UniCarb-DR, have been developed to accumulate experimental data generated by glycomics and glycoproteomics mass spectrometry experiments. In order to...

PI: Shunji Natsuka (Niigata University) Keywords: brain, Xenopus, N-glycans, pyridylamination N-glycans derived from Xenopus laevis brain were separated by reverse-phase LC and subsequently analyzed by ESI-MS/MS....

PI: Jeanne Stachowiak (University of Texas at Austin) Keywords: Muc1, mucin, endocytosis, clathrin-mediated endocytosis, sialylation Clathrin-mediated endocytosis is an essential cellular process that facilitates nutrient uptake, cell signaling, and recycling of membrane proteins. Many membrane proteins that are internalized by end...

PI: Kazuhiro Aoki (medical college of wisconsin) Keywords: mass spec, O-links, N-links O- and N-glycan released from cyrptococcus were analyzed by Orbitrap mass spec ...

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PI: Morten Thaysen-Andersen (School of Natural Sciences, Macquarie University) Keywords: Sialic acid, Glycocalyx remodeling, MALDI imaging, Tumor-associated macrophages This study demonstrates that macrophage polarization is accompanied by extensive remodeling of the cell surface glycocalyx, particularly through changes in sialic acid linkages. Pro-inflammatory macro...

PI: Xuezheng Song (Emory University School of Medicine, Atlanta, Georgia 30322, United States.) Keywords: MALDI-MS/MS; Structural Sequencing; Glycosaminoglycan Oligosaccharides In this study, we develop a one-step deuterated peracetylation-MALDI-MS/MS (OSDPM) analytical strategy that enables high-throughput structural characterization of HP/HS oligosaccharides with ng to sub...

PI: Jake Yang (Suzhou University) Keywords: Glycan; SARS-CoV-2; Vaccine; Antibody Titer; Mass Spectrometry Investigate how inactivated SARS-CoV-2 vaccines affect serum glycan profiles and their potential role in vaccine efficacy....

PI: Christopher Ashwood (Protea Glycosciences) Keywords: real-time, N-glycan, glycomics, GAG, polysaccharide Glycosylation is a structurally diverse, non-template-driven modification whose analysis by liquid chromatography–mass spectrometry is constrained by discovery-mode acquisition rules developed for pro...

PI: Edyta Skurska (University of Wroclaw) Keywords: glycosylation, GDP-fucose, O-glycans, N-glycans, SLC35C1, GMDS, TSTA3, FCSK Lack of SLC3C1 protein and enzymes of GDP-fucose biosynthesis cause reduction of fucosylated N- and O-glycans...

PI: Q. Paula Lei (Vaccine Production Program, Vaccine Research Center, National Institutes of Health) Keywords: Multi attribute monitoring method, MAM, Vaccine characterization Many protein-based vaccines comprise viral surface proteins which are chosen for their ability to stimulate the immune system. These vaccine molecules are often heavily glycosylated, and glycosylation...

PI: Guilherme Dotto Brand (Laboratório de Genética Clínica, Faculdade de Medicina, Universidade de Brasília, Brasília, Brasil) Keywords: Congenital disorders of glycosylation, inherited metabolic diseases, mass spectrometry, stable isotopic labeling, glycomics CDG-II diagnostic profiling...

PI: Richard D Cummings (Department of Surgery, Division of Surgical Sciences, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States) Keywords: glycomics, targeted, N-glycans, PGC Studies on N-glycans of human glycoproteins is hampered by the lack of standards that reflect the wide diversity in composition and branching typically observed. To this end we have exploited a large...

PI: Miyako Nakano (Hiroshima University) Keywords: integrin, extracellular vesicle, sEV, N-glycans, Neuro2A, A549, B16, LC-ESI MS Immunopurified integrin beta1 derived from Neuro2A, A549, and B16 cells and their sEVs were subjected to SDS-PAGE and the protein bands were transferred to a PVDF membrane. After staining with Direct ...

PI: Douglas Dyer and David Knight (The University of Manchester) Keywords: GAG disaccharide analysis, heparan sulphate, chondroitin sulphate, dermatan sulphate, hyaluronan Proteoglycans, and their glycosaminoglycan (GAG) side chains, are critical components of the ECM and the glycocalyx. GAGs can bind to many different proteins, such as chemokines, and form hydrated bar...

PI: Prof. Dr. Véronique Blanchard (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Augustenburger Platz 1, 13353 Berlin, Germany) Keywords: mesenchymal stem cells, N-glycans, glycomics, MALDI-TOF, permethylation, chondrogenic differentiation, dedifferentiation, aging Mesenchymal stem cells (MSCs) are adult stem cells able to self-renewal or to differentiation into a variety of cell types including chondrocytes. N-Glycans are post-translational modifications of gly...

PI: Abhay Pandit (Research Ireland Research Centre for Biomedical Devices) Keywords: intervertebral disc; N-glycan; degeneration This study characterizes glycan alterations in human healthy and degenerated IVDs using UPLC-MS...

PI: Daneil Bajar (Department of Chemistry and Molecular Biology, University of Gothenburg, 41390 Gothenburg, Sweden) Keywords: Glycobiology, nucleus, systems biology, bioinformatics, RNA-binding protein, O-linked glycans O-glycomics of cell lysates and nuclei of mammalian cell lines...

PI: Volkan Seyrantepe (İzmir Institute of Technology, Department of Molecular Biology and Genetics, İzmir, Turkey) Keywords: N-glycan, O-glycan, autophagy, ER stress, Tay-Sachs disease, lithium Tay-Sachs disease is a rare neurodegenerative disorder caused by mutations in the HEXA gene. HEXA gene encodes the α-subunit of the enzyme β-hexosaminidase A, which degrades GM2 ganglioside. Previousl...