How X and Y chromosomes mechanistically shape sex biology across the lifespan, with an emphasis on aging, neurologic and psychiatric conditions, immunity, cancer risk, and cardiometabolic disease? www.sciencemagazinedigital.org/sciencemagaz...
Science Magazine - X and Y chromosomes as determinants of aging and disease
Biological sex is defined by chromosomal complement (XX or XY), gonadal differentiation, and physiology, all of which profoundly affect human health.
www.sciencemagazinedigital.org
October 3, 2026 at 3:01 PM
How X and Y chromosomes mechanistically shape sex biology across the lifespan, with an emphasis on aging, neurologic and psychiatric conditions, immunity, cancer risk, and cardiometabolic disease? www.sciencemagazinedigital.org/sciencemagaz...
ICYMI: X and Y chromosomes as determinants of aging and disease | Science @Science.org
X and Y chromosomes as determinants of aging and disease | Science
Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX and XY complements alter gene dosage, epigenetic ...
dlvr.it
October 3, 2026 at 12:52 PM
ICYMI: X and Y chromosomes as determinants of aging and disease | Science @Science.org
X and Y chromosomes as determinants of aging and disease | Science www.science.org/doi/10.1126/...
X and Y chromosomes as determinants of aging and disease
Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...
www.science.org
October 3, 2026 at 10:04 AM
X and Y chromosomes as determinants of aging and disease | Science www.science.org/doi/10.1126/...
X and Y chromosomes as determinants of aging and disease | Science @Science.org
X and Y chromosomes as determinants of aging and disease | Science
Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX and XY complements alter gene dosage, epigenetic ...
dlvr.it
October 2, 2026 at 5:51 AM
X and Y chromosomes as determinants of aging and disease | Science @Science.org
X and Y chromosomes as determinants of aging and disease | Science www.science.org/doi/10.1126/...
X and Y chromosomes as determinants of aging and disease
Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...
www.science.org
October 2, 2026 at 1:48 AM
X and Y chromosomes as determinants of aging and disease | Science www.science.org/doi/10.1126/...
Review: X and Y chromosomes as determinants of aging and disease @denadubal.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
X and Y chromosomes as determinants of aging and disease
Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...
www.science.org
October 1, 2026 at 11:39 PM
Review: X and Y chromosomes as determinants of aging and disease @denadubal.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
X and Y chromosomes as determinants of aging and disease
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
X and Y chromosomes as determinants of aging and disease
Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...
www.science.org
October 1, 2026 at 7:10 PM
X and Y chromosomes as determinants of aging and disease
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congratulations Eric Schmitt on becoming MAGAS newest aspiring Republican Party's carnival dunking clown. Now, pull yourself up by your bootstraps, show the world some gonadal fortitude, and ride off into the sunset, 'cause you're pretty much boiled to the nub now.
October 1, 2026 at 4:13 PM
Congratulations Eric Schmitt on becoming MAGAS newest aspiring Republican Party's carnival dunking clown. Now, pull yourself up by your bootstraps, show the world some gonadal fortitude, and ride off into the sunset, 'cause you're pretty much boiled to the nub now.
🚨PREPRINT ALERT
How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for.
In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.
How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for.
In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.
Juvenile protein restriction compresses sexual dimorphism in mice
Sexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
www.biorxiv.org
September 30, 2026 at 9:37 AM
🚨PREPRINT ALERT
How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for.
In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.
How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for.
In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.
Turns out the gonadal artery and vein just kinda branch off if you have ovaries and testes at the same time! And idk what's going on with my uterine round ligaments and gubernacula testes but maybe they aren't actually connected? or maybe they are and it's just very thin?
September 30, 2026 at 12:50 AM
Turns out the gonadal artery and vein just kinda branch off if you have ovaries and testes at the same time! And idk what's going on with my uterine round ligaments and gubernacula testes but maybe they aren't actually connected? or maybe they are and it's just very thin?
Estoy criando una niña fuerte e independiente, pero empática y bondadosa aunque siempre alerta para aplastar gónadas de un rodillazo.
Madres de varones, en vuestras manos está la futura integridad gonadal de vuestros hijos.
Madres de varones, en vuestras manos está la futura integridad gonadal de vuestros hijos.
September 29, 2026 at 1:12 PM
Estoy criando una niña fuerte e independiente, pero empática y bondadosa aunque siempre alerta para aplastar gónadas de un rodillazo.
Madres de varones, en vuestras manos está la futura integridad gonadal de vuestros hijos.
Madres de varones, en vuestras manos está la futura integridad gonadal de vuestros hijos.
Wait until they start building a gonadal to the top because data centers can be air cooled up there.
September 27, 2026 at 4:39 PM
Wait until they start building a gonadal to the top because data centers can be air cooled up there.
They can.
"Patients with ovotesticular disorder of sex development (OT-DSD), which was previously called true hermaphroditism, have both functional ovarian and testicular tissue due to variations in spatiotemporal expression of genes driving gonadal differentiation"
www.eurorad.org/case/18659
"Patients with ovotesticular disorder of sex development (OT-DSD), which was previously called true hermaphroditism, have both functional ovarian and testicular tissue due to variations in spatiotemporal expression of genes driving gonadal differentiation"
www.eurorad.org/case/18659
www.eurorad.org
September 24, 2026 at 3:46 PM
They can.
"Patients with ovotesticular disorder of sex development (OT-DSD), which was previously called true hermaphroditism, have both functional ovarian and testicular tissue due to variations in spatiotemporal expression of genes driving gonadal differentiation"
www.eurorad.org/case/18659
"Patients with ovotesticular disorder of sex development (OT-DSD), which was previously called true hermaphroditism, have both functional ovarian and testicular tissue due to variations in spatiotemporal expression of genes driving gonadal differentiation"
www.eurorad.org/case/18659
🐟 His aim is to study the gonadal development of a Chilean population of Mugil cephalus, using @pie-upvehu.bsky.social’s Molecular Biology and Advanced Microscopy platforms. 🧫🔎
@embrcspain.bsky.social @embrc.eu
@embrcspain.bsky.social @embrc.eu
September 24, 2026 at 12:19 PM
🐟 His aim is to study the gonadal development of a Chilean population of Mugil cephalus, using @pie-upvehu.bsky.social’s Molecular Biology and Advanced Microscopy platforms. 🧫🔎
@embrcspain.bsky.social @embrc.eu
@embrcspain.bsky.social @embrc.eu
Those chromosomes don't create different sexes.
Sex is chromosomal, gonadal, hormonal...and more. The history of our species and that of other mammals depended on sex happening. Females with eggs. Males with sperms.
Evolution.
Gender is different. It is cultural. It is where our minds are free.
Sex is chromosomal, gonadal, hormonal...and more. The history of our species and that of other mammals depended on sex happening. Females with eggs. Males with sperms.
Evolution.
Gender is different. It is cultural. It is where our minds are free.
September 19, 2026 at 11:55 PM
Those chromosomes don't create different sexes.
Sex is chromosomal, gonadal, hormonal...and more. The history of our species and that of other mammals depended on sex happening. Females with eggs. Males with sperms.
Evolution.
Gender is different. It is cultural. It is where our minds are free.
Sex is chromosomal, gonadal, hormonal...and more. The history of our species and that of other mammals depended on sex happening. Females with eggs. Males with sperms.
Evolution.
Gender is different. It is cultural. It is where our minds are free.
Answer the question -
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Report of Fertility in a Woman with a Predominantly 46,XY Karyotype in a Family with Multiple Disorders of Sexual Development
Context: We report herein a remarkable family in which the mother of a woman with 46,XY complete gonadal dysgenesis was found to have a 46,XY karyotype in peripheral lymphocytes, mosaicism in cultured...
pmc.ncbi.nlm.nih.gov
September 19, 2026 at 4:37 PM
Answer the question -
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
("male" here meaning "exposed to gonadal testosterone during adolescence", "female" meaning "not", but that didn't fit in the post.)
September 18, 2026 at 3:09 PM
("male" here meaning "exposed to gonadal testosterone during adolescence", "female" meaning "not", but that didn't fit in the post.)
oh well i’ve been taking a class on biological modeling at night and applying for jobs i’ve also been trying to apply an interesting paper to various datasets; that is a paper a former pi sent me on treating hormonal and gonadal sex as a continuous variable based on transcriptional profiles
September 18, 2026 at 6:57 AM
oh well i’ve been taking a class on biological modeling at night and applying for jobs i’ve also been trying to apply an interesting paper to various datasets; that is a paper a former pi sent me on treating hormonal and gonadal sex as a continuous variable based on transcriptional profiles
🐦⬛🪶You will learn to embrace the beauty that others of real truth who are moved in a deep way to express what You YourSelf(s) find difficult to perceive especially because ofwho we are as Sex|Gonadal|Endocrine|Gender Expansive Nonconforming Variant people existing outside of common expectations🪶🪶
September 18, 2026 at 6:23 AM
🐦⬛🪶You will learn to embrace the beauty that others of real truth who are moved in a deep way to express what You YourSelf(s) find difficult to perceive especially because ofwho we are as Sex|Gonadal|Endocrine|Gender Expansive Nonconforming Variant people existing outside of common expectations🪶🪶
the really wild thing about this is that, because TERFs hold that gonadal tissue is the sole determinant of sex, they would say (& I have seen them say) that a girl with CAIS is actually a boy, so should be using the boys loos anyway
Every day, the stories from the UK read like a dystopian novel.
September 17, 2026 at 6:44 PM
the really wild thing about this is that, because TERFs hold that gonadal tissue is the sole determinant of sex, they would say (& I have seen them say) that a girl with CAIS is actually a boy, so should be using the boys loos anyway
They replumbed the gonadal vein not the ureter? Wow.
Did they not notice the erm gross haematuria?
Did they not notice the erm gross haematuria?
September 17, 2026 at 10:42 AM
They replumbed the gonadal vein not the ureter? Wow.
Did they not notice the erm gross haematuria?
Did they not notice the erm gross haematuria?
Looking at "sex chromosome anomalies" on wikipe and the fact they arbitrarily assigned gender to some of the combinations. Like XXYY is male?
ESPECIALLY when you have gonadal dygenesis just sitting there.
ESPECIALLY when you have gonadal dygenesis just sitting there.
September 15, 2026 at 2:18 PM
Looking at "sex chromosome anomalies" on wikipe and the fact they arbitrarily assigned gender to some of the combinations. Like XXYY is male?
ESPECIALLY when you have gonadal dygenesis just sitting there.
ESPECIALLY when you have gonadal dygenesis just sitting there.
Sex Cord-Gonadal Stromal Tumor Market Size, Growth, By 2035 www.marketresearchfuture.com/reports/sex-...
Sex Cord-Gonadal Stromal Tumor Market Size, Share & Growth Report 2035 | MRFR
The Sex Cord-Gonadal Stromal Tumor market is projected to grow from USD Billion 1.65 in 2024 to USD Billion 4.885 by 2035, at a CAGR of 10.37% during 2025-2035.
www.marketresearchfuture.com
September 15, 2026 at 6:02 AM
Sex Cord-Gonadal Stromal Tumor Market Size, Growth, By 2035 www.marketresearchfuture.com/reports/sex-...