Even initiator methionine tRNA genes were interesting.
One or more individual iMet tRNA genes emerged as fitness hits in 293T and BJ-hTERT cells BUT none did in two glioblastoma models we tested. Somewhat unexpected given the unique role of iMet tRNAs in translation initiation.
One or more individual iMet tRNA genes emerged as fitness hits in 293T and BJ-hTERT cells BUT none did in two glioblastoma models we tested. Somewhat unexpected given the unique role of iMet tRNAs in translation initiation.
September 28, 2026 at 9:07 AM
Even initiator methionine tRNA genes were interesting.
One or more individual iMet tRNA genes emerged as fitness hits in 293T and BJ-hTERT cells BUT none did in two glioblastoma models we tested. Somewhat unexpected given the unique role of iMet tRNAs in translation initiation.
One or more individual iMet tRNA genes emerged as fitness hits in 293T and BJ-hTERT cells BUT none did in two glioblastoma models we tested. Somewhat unexpected given the unique role of iMet tRNAs in translation initiation.
Profiling Pro-vasculogenic gene features of (primary & hTERT-immortalized) Smooth Muscle Cells
CD248/Endosialin is the key support; Contractile genes are enriched in non-supportive SMC lines
#Angiogenesis 2026
link.springer.com/article/10.1...
CD248/Endosialin is the key support; Contractile genes are enriched in non-supportive SMC lines
#Angiogenesis 2026
link.springer.com/article/10.1...
August 23, 2026 at 12:29 PM
Profiling Pro-vasculogenic gene features of (primary & hTERT-immortalized) Smooth Muscle Cells
CD248/Endosialin is the key support; Contractile genes are enriched in non-supportive SMC lines
#Angiogenesis 2026
link.springer.com/article/10.1...
CD248/Endosialin is the key support; Contractile genes are enriched in non-supportive SMC lines
#Angiogenesis 2026
link.springer.com/article/10.1...
New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-related disease.
Link as first comment.
#longevity #geroscience #hTERT #Follistatin344 #telomeres
Link as first comment.
#longevity #geroscience #hTERT #Follistatin344 #telomeres
September 25, 2026 at 7:42 PM
New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-related disease.
Link as first comment.
#longevity #geroscience #hTERT #Follistatin344 #telomeres
Link as first comment.
#longevity #geroscience #hTERT #Follistatin344 #telomeres
#Exosome from hTERT- #MesenchymalStemCell overexpressing PD-L1 + HGF i.v. Immediately following🐭Stroke
👉⏫Nestin+ neuroblast/astroglia
👉⏬Neural cell apoptosis
👉⏬Pro-inflamm leukocyte ⏫Anti-inflamm leukocyte
👉⏬infarct vol
⏫Neurobehaviors
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
👉⏫Nestin+ neuroblast/astroglia
👉⏬Neural cell apoptosis
👉⏬Pro-inflamm leukocyte ⏫Anti-inflamm leukocyte
👉⏬infarct vol
⏫Neurobehaviors
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
January 28, 2026 at 12:55 PM
#Exosome from hTERT- #MesenchymalStemCell overexpressing PD-L1 + HGF i.v. Immediately following🐭Stroke
👉⏫Nestin+ neuroblast/astroglia
👉⏬Neural cell apoptosis
👉⏬Pro-inflamm leukocyte ⏫Anti-inflamm leukocyte
👉⏬infarct vol
⏫Neurobehaviors
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
👉⏫Nestin+ neuroblast/astroglia
👉⏬Neural cell apoptosis
👉⏬Pro-inflamm leukocyte ⏫Anti-inflamm leukocyte
👉⏬infarct vol
⏫Neurobehaviors
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Weird virus fact: Papillomaviruses can make their host cell immortal 🧟♂️ by activating telomerase (together with other mechanisms).
The viral protein E6 regulates and directly interacts with hTERT and telomeric DNA.
The viral protein E6 regulates and directly interacts with hTERT and telomeric DNA.
May 6, 2025 at 8:15 PM
Weird virus fact: Papillomaviruses can make their host cell immortal 🧟♂️ by activating telomerase (together with other mechanisms).
The viral protein E6 regulates and directly interacts with hTERT and telomeric DNA.
The viral protein E6 regulates and directly interacts with hTERT and telomeric DNA.
🍃 This paper studies the #molecular #pharmacology of Bryophyllum pinnatum #herbal preparations using specific receptor #ligands, the human myometrial #cell line hTERT‑C3, and cell lines expressing #recombinant human #oxytocin and V1A receptors.
💻 www.thieme-connect.com/products/ejo...
💻 www.thieme-connect.com/products/ejo...
May 16, 2025 at 3:02 PM
🍃 This paper studies the #molecular #pharmacology of Bryophyllum pinnatum #herbal preparations using specific receptor #ligands, the human myometrial #cell line hTERT‑C3, and cell lines expressing #recombinant human #oxytocin and V1A receptors.
💻 www.thieme-connect.com/products/ejo...
💻 www.thieme-connect.com/products/ejo...
Integrated Multi-Omics Characterization of CDK4/hTERT-Immortalized Ovine Satellite Cells for Cultivated Meat Applications https://www.biorxiv.org/content/10.1101/2025.10.23.684220v1
October 28, 2025 at 11:46 AM
Integrated Multi-Omics Characterization of CDK4/hTERT-Immortalized Ovine Satellite Cells for Cultivated Meat Applications https://www.biorxiv.org/content/10.1101/2025.10.23.684220v1
Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.12.05.626964v1
December 5, 2024 at 10:30 PM
Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles https://www.biorxiv.org/content/10.1101/2024.12.05.626964v1
The authors included RRIDs in their in Journal of Biotechnology paper! We value the author's support of reproducibility. #RRID #BetterScience #methodsmatter
Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles
Read the full paper: Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles
doi.org
March 14, 2026 at 7:01 AM
The authors included RRIDs in their in Journal of Biotechnology paper! We value the author's support of reproducibility. #RRID #BetterScience #methodsmatter
Lipkin - another approach is to target a universal antigen like hTERT which is otherwise not normally expressed. Several ongoing studies in BRCA1/BRCA2 individuals.
April 26, 2025 at 4:04 PM
Lipkin - another approach is to target a universal antigen like hTERT which is otherwise not normally expressed. Several ongoing studies in BRCA1/BRCA2 individuals.
Cycloastragenol binds near hTERT, promoting nuclear localisation and telomerase activity in cell cultures. It also activates NRF2 under oxidative stress. (Su et al 2025)
September 22, 2026 at 5:01 PM
Cycloastragenol binds near hTERT, promoting nuclear localisation and telomerase activity in cell cultures. It also activates NRF2 under oxidative stress. (Su et al 2025)
Telomeres control regulation of the human Telomerase (hTERT) gene through non-telomeric TRF2 and independent of Telomere looping https://www.biorxiv.org/content/10.1101/2023.10.09.561466v1
Telomeres control regulation of the human Telomerase (hTERT) gene through non-telomeric TRF2 and independent of Telomere looping https://www.biorxiv.org/content/10.1101/2023.10.09.561466v1
Activation of human telomerase (hTERT) and resulting maintenance of telomeres is widely understood.
www.biorxiv.org
October 11, 2023 at 4:49 AM
Telomeres control regulation of the human Telomerase (hTERT) gene through non-telomeric TRF2 and independent of Telomere looping https://www.biorxiv.org/content/10.1101/2023.10.09.561466v1
A preprint using: BJ1-hTERT (RRID:CVCL_6573) from @cellosaurus.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
www.biorxiv.org
August 20, 2025 at 12:00 PM
A preprint using: BJ1-hTERT (RRID:CVCL_6573) from @cellosaurus.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
がん細胞は、テロメラーゼで寿命を延ばしていることが多い。
テロメライシンは、そのhTERTプロモーターを使って中で増えます。
増えると細胞が壊れる。食道がんでは放射線と一緒に使います。
壊れたあと、免疫が動くかもしれない、という話まで見ています。
なぜテロメライシンは、がん細胞の中で増えるのか
www.youtube.com/watch?v=WZwZ...
#hTERTプロモーターテロメライシン
テロメライシンは、そのhTERTプロモーターを使って中で増えます。
増えると細胞が壊れる。食道がんでは放射線と一緒に使います。
壊れたあと、免疫が動くかもしれない、という話まで見ています。
なぜテロメライシンは、がん細胞の中で増えるのか
www.youtube.com/watch?v=WZwZ...
#hTERTプロモーターテロメライシン
テロメライシンは、なぜ食道がんに効くのか？｜テロメア・hTERT・腫瘍溶解ウイルスをライブ解説
YouTube video by 医療ニュース解説 ステラチャンネル STELLA CHANNEL - 星良孝
www.youtube.com
August 29, 2026 at 9:33 AM
がん細胞は、テロメラーゼで寿命を延ばしていることが多い。
テロメライシンは、そのhTERTプロモーターを使って中で増えます。
増えると細胞が壊れる。食道がんでは放射線と一緒に使います。
壊れたあと、免疫が動くかもしれない、という話まで見ています。
なぜテロメライシンは、がん細胞の中で増えるのか
www.youtube.com/watch?v=WZwZ...
#hTERTプロモーターテロメライシン
テロメライシンは、そのhTERTプロモーターを使って中で増えます。
増えると細胞が壊れる。食道がんでは放射線と一緒に使います。
壊れたあと、免疫が動くかもしれない、という話まで見ています。
なぜテロメライシンは、がん細胞の中で増えるのか
www.youtube.com/watch?v=WZwZ...
#hTERTプロモーターテロメライシン
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
www.biorxiv.org
June 4, 2026 at 12:00 PM
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #STMpublishing
RRIDs were included in this paper. We value the author's support of reproducibility. #STMpublishing #RRID #accelerateopenscience
Generation of hTERT-immortalized human mesenchymal stromal cells with optical and magnetic labels for in vivo transplantation and tracking
doi.org
November 27, 2025 at 8:00 AM
RRIDs were included in this paper. We value the author's support of reproducibility. #STMpublishing #RRID #accelerateopenscience
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
www.biorxiv.org
August 1, 2025 at 12:00 PM
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
A redefined InDel taxonomy provides insights into mutational signatures
->Nature | More info from EcoSearch
->Nature | More info from EcoSearch
A redefined InDel taxonomy provides insights into mutational signatures
We generated a ‘ground truth’ set of isogenic cellular models by introducing CRISPR edits to key PRRd-associated genes in an hTERT-immortalized RPE1 (TP53−/−) cell line23. We created four single MMR gene knockouts (ΔMLH1, ΔMSH2, ΔMSH3 and ΔSETD2 (ref. 24)), two...
www.nature.com
April 10, 2025 at 10:58 PM
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
www.biorxiv.org
May 11, 2025 at 12:00 PM
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #OpenScience #reproducibility
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
www.biorxiv.org
May 21, 2026 at 12:00 PM
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #reproducibility
PAF15-PCNA exhaustion governs the strand-specific control of DNA replication
->Nature | More on "DNA replication control in cells" at BigEarthData.ai
->Nature | More on "DNA replication control in cells" at BigEarthData.ai
PAF15-PCNA exhaustion governs the strand-specific control of DNA replication
The human U2OS osteosarcoma cell line (ATCC, HTB-96), HeLa Kyoto cervical carcinoma cell line (CVCL_1922), primary immortalized retinal epithelial cell line hTERT-RPE1 (ATCC, CRL-4000), primary immortalized foreskin fibroblast BJ cells (ATCC, CRL-2522) and their derivatives were grown in Dulbecco’s modified...
www.nature.com
January 28, 2026 at 9:16 PM
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #STMpublishing
www.biorxiv.org
May 4, 2026 at 12:00 PM
Authors used hTERT-RPE1 from @cellosaurus.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #STMpublishing
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #STMpublishing
Authors used xlox(GFP)hTERT from @addgene.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #OpenScience
www.biorxiv.org
May 13, 2026 at 12:00 PM
Authors used xlox(GFP)hTERT from @addgene.bsky.social in their study. Including #RRIDs will make this less ambiguous.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #OpenScience
A preprint using: hTERT-HPNE (RRID:CVCL_C466) from @cellosaurus.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility
Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
www.biorxiv.org
April 19, 2026 at 12:00 PM
A preprint using: hTERT-HPNE (RRID:CVCL_C466) from @cellosaurus.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #reproducibility