Communications Engineering, Published online: 30 September 2026; doi:10.1038/s44172-026-00771-9Dr. Damiano Padovani and colleagues assess the current research landscape and identify crucial areas for future studies on blood-wetted cardiovascular devices, as their hemocompatibility remains unsatisfactory. Combining numerical methods with experiments is paramount and calls for collaboration among researchers with different backgrounds, clinicians, and industry.

Hemodialysis is indispensable for patients with end-stage renal disease (ESRD). Yet, the performance of conventional polymeric membranes is restricted by protein adsorption, poor hemocompatibility, and thrombo-inflammatory responses. We hypothesized that functional modification of a cellulose acetate (CA) ma

We describe the osteogenic potential and hemocompatibility of rare-earth-doped hydroxyapatite in a murine preosteoblastic (MC3T3-E1) cell line, aiming to assess the osteoblast differentiation effect o...

A biomimetic vascular graft combining biofunctionalized PVA-MA hydrogels with a MEW scaffold is developed for small-diameter applications. Gel-MA and Hep-MA incorporation enhances endothelialization ...

Antimicrobial resistance (AMR) presents a pressing global health crisis, particularly in the post-pandemic era, underscoring the urgent need for innovative therapeutics. Antimicrobial peptides (AMPs) hold promises for combating multidrug-resistant infections but are hindered by challenges in clinical translation, including limited hemocompatibility and inefficient design processes. To overcome these obstacles, we developed AIPAMPDS, an AI-driven computational platform that integrates a deep generative model with multi-stage screening to design highly active, non-haemolytic AMPs. The platform features two key modules: (1) a Generative Pre-trained Transformer (GPT)-based framework for target-specific AMP generation, enabling rapid exploration of novel peptide sequences, and (2) a multi-neural network screening pipeline for dual evaluation of antimicrobial activity and toxicity. By systematically evaluating both AI-generated and natural candidate AMPs, we identified ten lead peptides for experimental validation, of which 90% exhibited negligible haemolytic activity while maintaining robust antimicrobial potency. AIPAMPDS bridges computational design and therapeutic application, significantly advancing AMP discovery and providing a powerful tool for next-generation antimicrobial development. The platform is freely accessible via a web server at https://amps.pianlab.cn/AIPAMPDS/. ### Competing Interest Statement The authors have declared no competing interest.

Angiogenesis - Exploring the hemocompatibility of bioprosthetic heart valves (BHVs) has been challenging due to the scarcity of non-degenerated material. This study has two complementary objectives...

Read the full paper: Progressive endothelial coverage enhances hemocompatibility and prevents calcification in bioprosthetic valve tissue

Compliance mismatch and suboptimal hemocompatibility prevent the use of the traditional materials used for vascular prostheses or degradable synthetic…