Polydopamine-pillared composite graphene oxide membranes with tunable and stable interlayer spacing, featuring controllable interlayer spacing, are capable of sieving hydrated rubidium and potassium ions and delivering continuous freshwater production at high levels.

Polydopamine nanotubes use infrared light and ultrasound to heat cells, generate electrical stimulation, reduce oxidative stress and release bioactive dopamine.

Researchers at the Technical University of Munich (TUM) have developed hollow microspheres made of mucus and polydopamine using a simple and scalable production method.

Researchers at the Technical University of Munich (TUM) have developed hollow microspheres made of mucus and polydopamine using a simple and scalable production method. These tiny spheres are intended...

Targeted microparticles of polydopamine and iron oxide reveal site of leukocyte trafficking on magnetic resonance images.

AbstractThe spatial distribution of endogenous small-molecule metabolites is pivotal for understanding living processes, disease mechanisms, and therapeutic principles. However, achieving high-sensitivity spatial metabolomic profiling remains challenging for atmospheric pressure mass spectrometry imaging (AP-MSI) due to low desorption/ionization efficiency, leading to the systematic omission of low-abundance yet biologically vital metabolites from spatial maps. Here, we developed a high-sensitivity MSI platform that integrated a polydopamine/covalent organic framework (PDA/COF) composite substrate with atmospheric pressure laser ablation carbon fiber ionization (LACFI) technology for spatial mapping of endogenous small-molecule metabolites in biological tissues. This substrate employed a polydopamine (PDA) interlayer to guide the ordered assembly of a COF on the substrate. The resulting PDA/COF composite substrate exhibited uniform surface coverage, strong stability, and excellent light absorption, collectively improving the laser desorption/ionization efficiency of metabolites. Moreover, the substrate was simple, easy to use, and cost-effective. Our platform demonstrated a significantly enhanced sensitivity, achieving an improvement of more than 2-fold based on the slope of the linear calibration curve for analysis of metabolites compared with MALDI, DESI, LACFI using copper-coated, graphene oxide, and COF substrate. It also exhibited excellent linear response, wide dynamic range, and broad metabolite coverage. The platform was further applied to map the metabolomes of normal, para-cancerous, and cancerous liver tissues and, through heatmap analysis, clearly revealed the spatial distribution patterns of metabolites such as NAD+ and adenine across these tissue types. This method provides a straightforward, efficient, and robust AP-MSI platform for highly sensitive and comprehensive spatial metabolomics.

Read the full paper: Multifunctional biofunctionalized hybrid nanoantifungals with novel active coating agents based on cinnamaldehyde- and β-cyclocitral-modified polydopamine

Read the full paper: An Integrated Nano-Delivery Platform via Baicalein-Loaded Polydopamine-MOF for Enhanced Neuroprotection against Retinal Ischemia Reperfusion Injury

Lithium metal, a widely recognized anode material for next generation high energy density batteries, is hindered by challenges such as dendrite growth…

Read the full paper: Acupuncture with near-infrared irradiation using needles loaded with curcumin–polydopamine film attenuates papain-induced knee osteoarthritis in rats

Polydopamine (PDA) exhibits unique advantages in the treatment of oxidative damage owing to its melanin-mimetic structure, abundant redox-active functional groups, and excellent biocompatibility. Distinct from conventional antioxidant molecules, PDA-based nanoplatforms can efficiently eliminate reactive oxygen species (ROS) via hydrogen atom transfer and electron transfer mechanisms, while relying on the dynamic redox cycling of catechol/quinone moieties to achieve sustained antioxidant activity. However, systematic summaries of PDA-based antioxidant nanoplatforms remain relatively limited. Therefore, this review provides a comprehensive overview of the antioxidant mechanisms of PDA and its associated physicochemical properties, with particular emphasis on the design strategies of diverse PDA-based nanoplatforms, including solid, mesoporous, hollow, doped, and coated architectures, as well as the effects of structural features, particle size, composition, and surface charge on their antioxidant performance. In addition, recent research progress is systematically categorized around core pathological challenges, including breaking ROS-inflammation feedback loops, overcoming biological delivery barriers, remodeling regenerative microenvironments, and regulating programmed cell death.

The surface of polydimethylsiloxane (PDMS) can be modified to immobilize proteins; however, most existing approaches are limited to complex reactions and achiev

Advanced and novel effective wound dressings that decrease wound infections are essential for clinical application. In this study, a multifunctional hydrogel was engineered based on polyvinyl alcohol...

Rechargeable zinc–air batteries (ZABs) are promising for flexible energy storage due to their high specific energy, safety, and cost-effectiveness. However, the snags of the zinc (Zn) anode, like inel...

In this study, a dopamine derivative was synthesized and employed to yield self-adhering coatings that enabled both strong bacteria resistance and the fabrication of stable liquid-infused membranes (L...