RRIDs were included in this in Medical Oncology paper. We value the author's support of reproducibility. #accelerateopenscience #methodsmatter #RRID

HMGB1 Antibody Market Report | In-Depth Market Analysis 2035 | WiseGuyReports www.wiseguyreports.com/reports/hmgb...

Inflammation?

Here's a list of tests for Long COVID related inflammation:

CD40L
hs CRP (heart)
HMGB1
Hemopexin
IL-1β
IL-1RA
IL-2
IL-4
IL-6
IL-8
IL-10
IL-13
IL-17 A
IL-17 F
IL-18
iNOS (inducible nitric oxide synthase)
NF-κB
OSM (Oncostatin M)
Resistin
STAMBPL1
sTNF-α
TNF-α
TNF-1
TNSF11
TNSF14

Resistin hits BTK to keep NLRP3 inflammasome active

PLOS ONE: hResistin binds BTK directly, autophosphorylates it, and HMGB1 carries the signal to sustain inflammasome activation in macrophages.
journals.plos.org/plosone/arti...

pathways, further suggesting that the TG-SGCs-HMGB1 axis plays a critical role in the pathogenesis of migraine. The novelty of this review lies in proposing an integrated framework in which the TG-SGCs-HMGB1 amplification loop (🧵 7/9)

chronification of pain. In addition, existing studies have systematically indicated that active components of TCM may exert anti-inflammatory and analgesic effects by inhibiting SGCs activation, interfering with HMGB1 release, or blocking its receptors and downstream signaling (🧵 6/9)

Previous studies have shown that SGCs activation, HMGB1 externalization, and its downstream inflammatory cascades collectively contribute to neuroimmune imbalance within the TG, and may constitute an important amplification loop driving peripheral sensitization in migraine. In (🧵 4/9)

Upon external stimulation, neurons and SGCs can release alarmin high mobility group protein B1(HMGB1), which binds to specific receptors to activate inflammasomes, thereby further amplifying local inflammatory responses and neuronal excitability. (🧵 3/9)

Mechanism of SGCs-HMGB1 axis-mediated peripheral sensitization in migraine based on neuroimmune microenvironment of trigeminal ganglion and traditional Chinese medicine intervention
▶️ Read Full Paper

📚 Source: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia me

TG-SGCs-HMGB1 축이 편두통의 병인에서 결정적인 역할을 한다는 점을 더욱 시사한다. 본 문헌 고찰의 독창성은 TG-SGCs-HMGB1 증폭 루프가 말초 감작의 핵심 허브 역할을 하는 통합적 틀을 제안하고, 편두통의 한의학적 병인론 및 한의학적 노드 기반 중재의 관점에서 관련 연구 진전을 종합한 데 있으며, 이를 통해 편두통의 기전 연구와 한의학적 정밀 중재에 대한 참고 자료를 제공하는 데 목적을 두고 있다. (🧵 4/4)

한의학에서 편두통의 병인은 풍(風), 열(熱), 담(痰), 혈어(血瘀)와 밀접한 관련이 있다. 이러한 병리학적 변화는 어느 정도 삼각신경절(TG)의 신경면역 미세환경 조절 장애, 염증 매개체의 지속적 방출, 그리고 통증의 만성화와 일치한다. 또한, 기존 연구들은 한의학의 활성 성분들이 SGCs의 활성화를 억제하거나, HMGB1의 방출을 방해하거나, 또는 그 수용체와 하류 신호 전달 경로를 차단함으로써 항염증 및 진통 효과를 발휘할 수 있음을 체계적으로 보여주었으며, 이는 (🧵 3/4)

외부 자극이 가해지면 신경세포와 SGC는 알라민인 고이동성 그룹 단백질 B1(HMGB1)을 분비할 수 있으며, 이는 특정 수용체에 결합하여 인플라마좀을 활성화함으로써 국소 염증 반응과 신경세포의 흥분성을 더욱 증폭시킨다. 선행 연구에 따르면, SGC의 활성화, HMGB1의 외부 방출 및 그에 따른 하류 염증 반응 연쇄는 TG 내 신경면역 불균형에 종합적으로 기여하며, 편두통에서 말초 감작을 유도하는 중요한 증폭 루프를 형성할 수 있는 것으로 나타났다. (🧵 2/4)

삼차신경절의 신경면역 미세환경과 한의학적 중재를 바탕으로 한 편두통에서 SGCs-HMGB1 축에 의해 매개되는 말초 감작의 기전
▶️ 논문읽기

📚 출처: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
👤 저자: Zhu-Jun Wang et al.
📅 날짜: 2026년 09월 03일

🆔 PMID: 42693009
🔗 DOI: 10.19540/j.cnki.cjcmm.20260430.363

#편두통논문g/%ED%8E%B8%EB%91%90%ED%86%B5%EB%85%BC%EB%AC%B8" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#편두통논문 #편두통hashtag/%ED%8E%B8%EB%91%90%ED%86%B5" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#편두통 #

These findings support a potential role of HMGB1 in migraine-related neuroinflammatory processes. Further studies are needed to clarify the relationship between inflammatory pathways and cognitive symptoms in migraine. (🧵 10/10)

CONCLUSION: Serum HMGB1 levels were elevated in CM patients and were associated with migraine-related subjective cognitive complaints, whereas no significant association was observed with miR-146 or IL-17 levels. (🧵 9/10)

There was no significant correlation between HMGB1 and IL-17 (r = 0.167) or HMGB1 and miR146 levels (r = 0.073). Mig-SCog scores (p = 0.001) differed significantly between the groups and were positively correlated with HMGB1 levels (r = 0.403). (🧵 8/10)

RESULTS: Serum HMGB1 levels were significantly elevated in the CM group compared to the control group (p = 0.012). However, no significant differences were observed between the two groups for serum IL-17 (p = 0.737) or miR-146 levels (p = 0.560). (🧵 7/10)

Statistical analysis of the data was conducted with SPSS 25.0. The relationships between Mig-SCog scores and serum HMGB1, IL-17, and miR-146 levels were investigated. (🧵 6/10)

scores were recorded. Serum HMGB1 and IL-17 levels were measured using an enzyme-linked immunosorbent assay. A quantitative real-time polymerase chain reaction was used to measure serum miR-146 levels. (🧵 5/10)

IL-17 is another proinflammatory cytokine implicated in both inflammation and cognitive processes. In this research, our aim was to investigate the relationship between serum HMGB1, IL-17, and miR-146 levels and migraine-related subjective cognitive symptoms in patients with CM. (🧵 3/10)

miR-146, a microRNA involved in the TLR-4/NFkb pathway, is known to regulate proinflammatory signaling, whereas HMGB1 activates inflammatory pathways through TLR2 and TLR4 receptors. (🧵 2/10)

Exploratory evaluation of miR-146, inflammatory biomarkers, and subjective cognitive symptoms in chronic migraine
▶️ Read Full Paper

📚 Source: Turkish journal of medical sciences
👤 Creator: Hale Gök Dağidir et al.
📅 Date: 2026-09-01

#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper #Migraine/hashtag/Migraine" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#Migraine #PubMed="/hashtag/PubMed" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#PubMed

연관성이 관찰되지 않았다. 이러한 결과는 편두통 관련 신경염증 과정에서 HMGB1이 잠재적인 역할을 할 수 있음을 뒷받침한다. 편두통에서 염증 경로와 인지 증상 간의 관계를 명확히 하기 위해서는 추가 연구가 필요하다. (🧵 6/6)

Mig-SCog 점수(p = 0.001)는 두 군 간에 유의미한 차이를 보였으며, HMGB1 수치와 양의 상관관계를 나타냈다(r = 0.403).

결론: CM 환자에서 혈청 HMGB1 수치가 상승되어 있었으며, 이는 편두통 관련 주관적 인지 불만과 연관된 반면, miR-146 또는 IL-17 수치와는 유의미한 (🧵 5/6)

결과: CM군은 대조군에 비해 혈청 HMGB1 수치가 유의하게 상승되어 있었다(p = 0.012). 그러나 혈청 IL-17 (p = 0.737) 또는 miR-146 농도 (p = 0.560)에 대해서는 두 그룹 간에 유의한 차이가 관찰되지 않았습니다. HMGB1과 IL-17(r = 0.167) 또는 HMGB1과 miR-146 농도(r = 0.073) 간에는 유의한 상관관계가 나타나지 않았다. (🧵 4/6)