#hmgb1
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haoyin.bsky.social
Astroglial Hmgb1 in postnatal #Astrocyte morphogenesis & #NeuroGlioVascularUnit maturation
#SciArt

Aldh1l1-CreERT2:Hmgb1 f/f🐭➡️
⏬Astroglial endfeet coverage over vessels
⏬Single-cell #BranchingMorphogenesis

@blacoste.bsky.social @naturecomms.bsky.social 2023
www.nature.com/articles/s41...
December 31, 2024 at 1:42 PM
lozanzi.bsky.social
#WeekendRead! #MisterySolved! Overstreet Messer &co show @cp-cellhostmicrobe.bsky.social that HMGB1 in the gut mucus broadly targets a bacterial virulence factor preventing bacterial mucus invasion & tissue adhesion! #IBD is associated with low HMGB1!
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier
Trillions of adhesion-capable bacteria reside in the gut, yet they rarely attach to healthy host tissue. Here, Overstreet et al. reveal that HMGB1 in colonic mucus directly targets bacterial adhesins ...
www.cell.com
March 1, 2026 at 3:46 PM
teiflab.bsky.social
Saunders et al., 2025. HMGB1 deforms nucleosomal DNA to generate a dynamic chromatin environment counteracting the effects of linker histone www.science.org/doi/full/10....
▶️HMGB1 sites are away from where H1 binds
▶️HMGB1 increases nucleosomal DNA accessibility without displacing H1
August 19, 2025 at 9:43 AM
cp-cellchembiol.bsky.social
Aptamer targeting HMGB1 attenuates inflammatory disease via domain-specific antagonism
Aptamer targeting HMGB1 attenuates inflammatory disease via domain-specific antagonism
Zhang et al. describe ZH-1a, a high-affinity DNA aptamer that preferentially targets the HMGB1 B-box domain. By neutralizing extracellular HMGB1, ZH-1a suppresses inflammatory signaling, protects against acute inflammatory injury and polymicrobial sepsis, and enhances methotrexate efficacy in an arthritis model.
dlvr.it
August 21, 2026 at 4:01 PM
thailandmedical.bsky.social
New SARS-CoV-2 Variants Possibly Linked to Persistent Low Grade HMGB1-Mediated Inflammation

www.thailandmedical.news/news/new-sar...
New SARS-CoV-2 Variants Possibly Linked to Persistent Low Grade HMGB1-Mediated Inflammation - Thailand Medical News
www.thailandmedical.news
May 31, 2025 at 3:08 AM
labwaggoner.bsky.social
HMGB1 couples LEF1 to regulate B cell immunity @jci-insight.bsky.social
insight.jci.org/articles/vie...
September 24, 2025 at 2:24 AM
sbilbo.bsky.social
Happy to share the latest paper from the lab on sex differences in the neuroimmune mechanisms underlying anxiety. www.sciencedirect.com/science/arti...
Sex-specific regulation of microglial MyD88 in HMGB1-Induced anxiety phenotype in mice
Stress is a significant risk factor for the development and recurrence of anxiety disorders. Stress can profoundly impact the immune system, and lead …
www.sciencedirect.com
March 31, 2025 at 5:03 PM
yourdigitalbrain.bsky.social
Blocking the HMGB1 protein in the blood makes it possible to halt the spread of cellular aging, offering a new strategy to reverse muscle decay.
April 27, 2026 at 3:00 AM
jthjournal.bsky.social
JTH #December Issue is Here! 🌟
📖 Editorial on interdisciplinarity in thrombosis research
🧬 Insights into von Willebrand disease
🧪 Platelet-derived HMGB1 in thrombosis & immunity
💡 Anticoagulation for splanchnic vein thrombosis
and many more!

🔗 www.jthjournal.org/issue/S1538-...

#MedSky #HemeSky
December 5, 2024 at 9:07 AM
cp-cellhostmicrobe.bsky.social
Featured Article: HMGB1 guards gut mucosal barrier

HMGB1 in colonic mucus directly targets bacterial adhesins to protect the gut epithelium against commensal bacteria. Ulcerative colitis is associated with HGMB1 failure & adhesion of target bacteria
www.cell.com/cell-host-mi...
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier
Trillions of adhesion-capable bacteria reside in the gut, yet they rarely attach to healthy host tissue. Here, Overstreet et al. reveal that HMGB1 in colonic mucus directly targets bacterial adhesins ...
www.cell.com
February 13, 2026 at 4:27 PM
cp-cellhostmicrobe.bsky.social
HMGB1 guards gut mucosal barrier

HMGB1 in colonic mucus directly targets bacterial adhesins to protect the gut epithelium against commensal bacteria. Ulcerative colitis is associated with HGMB1 failure & adhesion of target bacteria
www.cell.com/cell-host-mi...
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier
Trillions of adhesion-capable bacteria reside in the gut, yet they rarely attach to healthy host tissue. Here, Overstreet et al. reveal that HMGB1 in colonic mucus directly targets bacterial adhesins ...
www.cell.com
February 4, 2026 at 7:20 PM
cyrilpedia.bsky.social
'Fatty food consumption has been shown to increase extracellular HMGB1, a key player in driving sterile inflammation. In this study, we show in mice that aging impairs the ability to produce, after stimulation of HMGB1, a neutralizing anti-HMGB1 IgM autoantobody that controls the EC HMGB1 level'
Age-related decline in HMGB1-neutralizing IgM autoantibody response impairs resistance to high-fat diet in mice
Abstract. As we age, it becomes increasingly important to reduce the consumption of fatty foods. In mice, we also find that after consuming a high-fat diet
academic.oup.com
August 4, 2025 at 7:44 AM
allostericstate.bsky.social
pubpeer.com/publications... #CryoEM Lots of issues with this new publication from the Jang group based at Pusan National University. These issues are a pattern with their other cryo-EM work all published in @elsevierconnect.bsky.social journals.
PubPeer - Cryo-EM structure of HMGB1-RAGE complex and its inhibitory e...
There are comments on PubPeer for publication: Cryo-EM structure of HMGB1-RAGE complex and its inhibitory effect on lung cancer (2025)
pubpeer.com
May 12, 2025 at 8:06 PM
thetinyscientist.bsky.social
Our findings of prolonged HMGB1 nuclear loss within rat cortical neurons in a fluid percussion injury model! Some beautiful images of rat cortical cells. This study was a blast ! (Get it?) #neuroscience #canadaresearch #womeninstem #traumaticbraininjury

www.sciencedirect.com/science/arti...
Prolonged loss of nuclear HMGB1 in neurons following modeled TBI and implications for long-term genetic health
Under normal physiological conditions high mobility group box protein 1 (HMGB1) stabilizes chromatin, controls transcription, and contributes to DNA r…
www.sciencedirect.com
March 14, 2025 at 9:49 PM
labwaggoner.bsky.social
Aptamer targeting HMGB1 attenuates inflammatory disease via domain-specific antagonism @cp-cellchembiol.bsky.social
www.cell.com/cell-chemica...
Aptamer targeting HMGB1 attenuates inflammatory disease via domain-specific antagonism
Zhang et al. describe ZH-1a, a high-affinity DNA aptamer that preferentially targets the HMGB1 B-box domain. By neutralizing extracellular HMGB1, ZH-1a suppresses inflammatory signaling, protects agai...
www.cell.com
July 20, 2026 at 10:56 PM
insightrx.bsky.social
HMGB1 Antibody Market Report | In-Depth Market Analysis 2035 | WiseGuyReports www.wiseguyreports.com/reports/hmgb...
www.wiseguyreports.com
September 25, 2026 at 9:27 AM
haoyin.bsky.social
#PulmonaryArterialHypertension #YAP

Pharmacological inhibition of HMGB1 (glycyrrhizin), YAP (verteporfin), or PFKFB3 (3PO) ⏬rat PAH (monocrotaline)

HMGB1/ROCK/YAP/PFKFB3/glycolysis cascade in pulmonary arterial smooth muscle cell proliferation

#JBC 2025
www.jbc.org/article/S002...
January 30, 2026 at 8:32 PM
cp-cellrepmed.bsky.social
Online now: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion
Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion
Onimus et al. find that select cytotoxic therapies induce active HMGB1 secretion and show combinatorial efficacy with anti-TIM-3 antibodies. Taxanes specifically promoted HMGB1 release via TLR4-driven ROS production and DNA damage, which activated the cGAS-STING pathway to promote ER stress, HMGB1 exocytosis, and chemoimmunotherapeutic efficacy.
dlvr.it
May 24, 2026 at 12:27 PM
cyrilpedia.bsky.social
'These results showed that HMGB1 inhibited IFN-γ–induced PD-L1 expression, thereby enhancing the antitumor effects of T cells, and confirmed the role of HMGB1 as a prognostic indicator for lung cancer treated with chimeric antigen receptor T cells.'
academic.oup.com/jimmunol/adv...
HMGB1 inhibits the IFN-γ–induced PD-L1 expression in NSCLC
Abstract. T cells are the most important cytotoxic cells involved in antitumor immune responses. After recognizing the major histocompatibility complex (MH
academic.oup.com
July 3, 2025 at 11:57 PM
lifespannews.bsky.social
A new study described how the reduced isoform of the SASP factor HMGB1 causes senescence to spread. Targeting HMGB1 with an antibody improves muscle regeneration in mice.

www.lifespan.io/news/researc...
By: Josh Conway
Researchers Identify a Key Senescence-Spreading Factor
In Metabolism Clinical & Experimental, researchers have described how the reduced isoform of the SASP factor HMGB1 causes senescence to […]
www.lifespan.io
August 21, 2025 at 8:09 PM
royalsocietypublishing.org
HMGB1 and mitochondrial dysfunction: a double-edged sword in ageing royalsocietypublishing.org/doi/10.1098/... | #CellularBiology #SystemsBiology #MolecularBiology
October 19, 2025 at 1:02 PM
labwaggoner.bsky.social
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier by binding to a broadly utilized amino acid motif in bacterial adhesins, w/ HGMB1 failure linked to ulcerative colitis @cp-cellhostmicrobe.bsky.social @clevelandclinic.bsky.social
www.cell.com/cell-host-mi...
February 3, 2026 at 10:51 PM
payalyokota.bsky.social
Heping Xu's team show in their study how ILC2 promote neutrophil infiltration by releasting HMGB1-loaded lipid droplets in allergy models induced by alarmins such as IL-33. [2/n]

www.cell.com/immunity/ful...
www.cell.com
October 3, 2024 at 7:55 PM
thailandmedical.bsky.social
How a Key Protein:  HMGB1 Can Influence Colitis and Colon Cancer Development

www.thailandmedical.news/news/how-a-k...
How a Key Protein: HMGB1 Can Influence Colitis and Colon Cancer Development - Thailand Medical News
www.thailandmedical.news
June 22, 2024 at 11:15 PM
biorxiv-microbiol.bsky.social
Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis https://www.biorxiv.org/content/10.1101/2025.01.07.631509v1
January 8, 2025 at 12:17 AM