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How can a single antibiotic halt translation across all domains of life? 🧬

Our new study in Nucleic Acids Research reveals how Sparsomycin traps active ribosomes through a conserved mechanism.
academic.oup.com/nar/article/...

#Ribosome #Translation #StructuralBiology #Antibiotics #RNA #iTPseq
Graphical representation of the T. thermophilus 70S ribosome showing the 30S and 50S subunits, mRNA, and P-site tRNA. Sparsomycin (yellow) binds in the peptidyl transferase center at the interface between the A and P sites. The enlarged view shows sparsomycin occupying the A-site cleft adjacent to the P-site fMet-tRNA, closely contacting its 3′ CCA end (C74, C75 and A76) and the attached fMet.
September 21, 2026 at 5:56 PM