Common immune system mediated threads of Alzheimer's disease and age-related macular degeneration, a new open-access review @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
May 4, 2025 at 3:29 PM
Common immune system mediated threads of Alzheimer's disease and age-related macular degeneration, a new open-access review @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
August 4, 2025 at 9:09 PM
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
It’s an immune mediated response.
Instead of myocytes building stuff immune cells turn up and burn the place to the ground.
Instead of myocytes building stuff immune cells turn up and burn the place to the ground.
November 29, 2024 at 3:42 AM
It’s an immune mediated response.
Instead of myocytes building stuff immune cells turn up and burn the place to the ground.
Instead of myocytes building stuff immune cells turn up and burn the place to the ground.
A new take from the Corbett lab on ubiquitin-like proteins in bacterial immune systems - oligomerization is mediated by calcium ions. Reminiscent of calcium-mediated immune signaling in human? Interesting.
Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1
Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1
Bacteria possess a variety of operons with homology to eukaryotic ubiquitination pathways that encod
www.biorxiv.org
November 22, 2024 at 10:42 AM
A new take from the Corbett lab on ubiquitin-like proteins in bacterial immune systems - oligomerization is mediated by calcium ions. Reminiscent of calcium-mediated immune signaling in human? Interesting.
Hello, world! We don’t routinely measure the immune system in the clinical laboratory. I’m working to make immune-based clinical tests a cornerstone of treatment selection, prognostication, and strategies to reprogram immunity across immune-mediated disease. Snapshot of my past work so far:
November 27, 2024 at 8:42 PM
Hello, world! We don’t routinely measure the immune system in the clinical laboratory. I’m working to make immune-based clinical tests a cornerstone of treatment selection, prognostication, and strategies to reprogram immunity across immune-mediated disease. Snapshot of my past work so far:
MR NOODLES HAS OFFICIALLY DEFEATED IMMUNE MEDIATED THROMBOCYTOPENIA 🎊🎉🎊🎉🎊🎉🎊🎉🎊
January 31, 2025 at 8:34 PM
MR NOODLES HAS OFFICIALLY DEFEATED IMMUNE MEDIATED THROMBOCYTOPENIA 🎊🎉🎊🎉🎊🎉🎊🎉🎊
"Our analysis suggests that mirror bacteria would likely evade many immune mechanisms mediated by chiral molecules, potentially causing lethal infection in humans, animals, and plants."
December 12, 2024 at 7:48 PM
"Our analysis suggests that mirror bacteria would likely evade many immune mechanisms mediated by chiral molecules, potentially causing lethal infection in humans, animals, and plants."
I wouldn't have anticipated a Lupus self-directed antibody (4H2) might someday turn out to be an anti-cancer treatment
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.
www.science.org
March 25, 2025 at 6:37 PM
I wouldn't have anticipated a Lupus self-directed antibody (4H2) might someday turn out to be an anti-cancer treatment
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The replies to this are yet another giant red flag that your perception of reality is very much mediated through your community, that you’re not immune because you’re left of center, and that you should not assume that a community being online-only reduces this effect in any way
I understand why people are exhausted by AI hype, and why those of us squarely in the corner of "human dignity uber alles" see AI doomerism as self-serving hype, but I *really* think people on the left broadly need to start thinking seriously about the possibiltiy of the hype being...true.
February 12, 2026 at 11:22 AM
The replies to this are yet another giant red flag that your perception of reality is very much mediated through your community, that you’re not immune because you’re left of center, and that you should not assume that a community being online-only reduces this effect in any way
I am leaving Musk-land for good and have just reactivated this semi-dormant profile...Anybody interested in the genetics of immune-mediated disease? #Genesky #immunosky
August 15, 2024 at 8:56 PM
I am leaving Musk-land for good and have just reactivated this semi-dormant profile...Anybody interested in the genetics of immune-mediated disease? #Genesky #immunosky
So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...
GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus
During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.
www.science.org
March 21, 2025 at 7:57 PM
So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...
Nature research paper: Microbiota-induced T cell plasticity enables immune-mediated tumour control
go.nature.com/4qMqEwJ
go.nature.com/4qMqEwJ
Microbiota-induced T cell plasticity enables immune-mediated tumour control - Nature
Molecular mimicry between a gut commensal and a tumour antigen forms part of an important mechanistic framework that can boost the efficacy of immune checkpoint blockade therapy and restrain tumour growth.
go.nature.com
January 21, 2026 at 9:14 AM
Nature research paper: Microbiota-induced T cell plasticity enables immune-mediated tumour control
go.nature.com/4qMqEwJ
go.nature.com/4qMqEwJ
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
www.nature.com
October 1, 2025 at 5:57 PM
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
Mr Noodles is at the vet getting checked to see if the treatment for his immune-mediated thrombocytopenia was effective or not. im anxious 😭
December 23, 2024 at 5:49 PM
Mr Noodles is at the vet getting checked to see if the treatment for his immune-mediated thrombocytopenia was effective or not. im anxious 😭
Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Antibody-mediated feedback modulates interclonal competition in the germinal center
Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influen...
www.biorxiv.org
November 8, 2025 at 3:04 PM
Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Study: Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System
www.preprints.org/manuscript/2...
www.preprints.org/manuscript/2...
www.preprints.org
July 28, 2025 at 3:02 AM
Study: Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System
www.preprints.org/manuscript/2...
www.preprints.org/manuscript/2...
Review: Flu arm soreness came on strong, with covid arm building later on; 18 hours or so of a delightful sense of mild immune-mediated fluishness, accompanied by some batshit fever dreams. 10/10, get your shots, vaccines rule.
Flu shot in one arm, new covid shot in the other. Who has a brick wall I can run through.
September 9, 2024 at 7:01 PM
Review: Flu arm soreness came on strong, with covid arm building later on; 18 hours or so of a delightful sense of mild immune-mediated fluishness, accompanied by some batshit fever dreams. 10/10, get your shots, vaccines rule.
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.
www.science.org
October 8, 2025 at 7:04 PM
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
COVID-19: a potential driver of immune-mediated breast cancer recurrence?
Francescangeli et al 2020
breast-cancer-research.biomedcentral.com/articles/10....
Francescangeli et al 2020
breast-cancer-research.biomedcentral.com/articles/10....
COVID-19: a potential driver of immune-mediated breast cancer recurrence? - Breast Cancer Research
Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously im...
breast-cancer-research.biomedcentral.com
February 8, 2025 at 12:47 AM
COVID-19: a potential driver of immune-mediated breast cancer recurrence?
Francescangeli et al 2020
breast-cancer-research.biomedcentral.com/articles/10....
Francescangeli et al 2020
breast-cancer-research.biomedcentral.com/articles/10....
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
July 21, 2025 at 7:01 PM
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
A microbiome gut-brain pathway influenced by intestinal metabolites, innate immune responses, vagal nerve signaling and hippocampal memory encoding, impacts the rate of cognitive decline. Many potential points of intervention are described.
#Science 🧪
#Science 🧪
Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature
Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...
www.nature.com
March 14, 2026 at 7:30 PM
A microbiome gut-brain pathway influenced by intestinal metabolites, innate immune responses, vagal nerve signaling and hippocampal memory encoding, impacts the rate of cognitive decline. Many potential points of intervention are described.
#Science 🧪
#Science 🧪
We might find treatments to slow the cause of worsening kidney function.
Maybe it’s immune mediated, maybe persistent virus, perhaps BP problems… who knows…
But that will cost too.
Maybe it’s immune mediated, maybe persistent virus, perhaps BP problems… who knows…
But that will cost too.
December 31, 2024 at 10:17 AM
We might find treatments to slow the cause of worsening kidney function.
Maybe it’s immune mediated, maybe persistent virus, perhaps BP problems… who knows…
But that will cost too.
Maybe it’s immune mediated, maybe persistent virus, perhaps BP problems… who knows…
But that will cost too.
Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal
imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy.
This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated
downregulation ...
www.embopress.org
January 3, 2025 at 9:30 AM
Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....
All those medicos and science journalists writing best sellers about how to age better and live longer - why are you not mentioning the importance of avoiding COVID, given the bucket loads of medical science showing how COVID causes cellular senescence?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system - Cell Death & Disease
Cell Death & Disease - Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system
www.nature.com
January 17, 2026 at 1:00 AM
All those medicos and science journalists writing best sellers about how to age better and live longer - why are you not mentioning the importance of avoiding COVID, given the bucket loads of medical science showing how COVID causes cellular senescence?
www.nature.com/articles/s41...
www.nature.com/articles/s41...